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  • Labormedizin
  • Allgemeine medizinische Zeitschriften
  • Endokrinologie
  • Springer  (38)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 57 (1979), S. 199-214 
    ISSN: 1432-1440
    Keywords: Glycoproteins ; Glycosyltransferases ; Lectin-like proteins ; Oncology ; Immunology ; Gastroenterology ; Hematology and Hemostaseology ; Pulmology ; Neurology ; Glycoproteine ; Glycosyltransferasen ; Lectin-analoge Proteine ; Onkologie ; Immunologie ; Gastroenterologie ; Pulmologie ; Endokrinologie ; Hämatologie u. Blutgerinnung ; Neurologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zunehmende chemische und biochemische Kenntnisse über Struktur, Biosynthese und Katabolismus der Glycoproteine haben auch neue Einblicke in die Pathobiochemie und klinische Bedeutung der Glycoproteine ermöglicht, die in Teil II dieser Übersicht unter Berücksichtigung ausgewählter klinischer Fachgebiete dargestellt werden: 1. Die Glycoproteine der Plasmamembran des Erytrozyten beeinflussen entscheidend sowohl die Antigenität als auch die in-vivo Halbwertszeit dieser Zellen. Pathologische Glycoproteinmuster der Erythrozyten-Membran sind bei verschiedenen Anämie-Formen beschrieben. Auch bestimmte Störungen der Blutgerinnung können als Ergebnis eines veränderten Glycoproteinmusters sowohl der Thrombozyten-Membran als auch einiger Gerinnungsfaktoren gedeutet werden. 2. Die terminalen Kohlenhydratreste zirkulierender Glycoproteine bestimmen deren in-vivo-Halbwertszeit. Da bei Lebererkrankungen eine gestörte Glycosylierung dieser Proteine möglich ist, sind hiermit neue Ansätze zur Interpretation veränderter Glycoproteinkonzentrationen und Enzymaktivitäten im Plasma bei diesen Erkrankungen gegeben. Lectin-analoge Proteine der Plasmamembran von Hepatozyten sind wahrscheinlich an der Genese von Lebererkrankungen beteiligt. 3. Ebenso sind die Glycoproteine des Tracheobronchialsekrets bei verschiedenen Erkrankungen strukturellen Änderungen unterworfen, die auch für das pathobiochemische Verständnis von Bedeutung sein können. 4. Über die strukturabhängige Funktion der Glycoproteine des Genitaltrakts und deren endokrinologische Steuerung liegen neue Erkenntnisse vor. Daneben wird durch die terminalen Kohlenhydratreste verschiedener Hypophysen-Hormone deren Akzeptor-Rezeptor-Spezifität mitbestimmt. 5. Über die Rolle terminaler Zuckerreste von Glycokonjugaten bei der Kontaktfindung von Nervenzellen sowie bei der Erregungsausbreitung liegen, teilweise noch hypothetische, Denkmodelle vor. Sowohl bei genetisch determinierten als auch erworbenen malignen und benignen Erkrankungen des Zentralnervensystems sind pathologische Glycoproteinmuster oder Glycosyltransferase- und Glycosidase-Aktivitäten nachgewiesen. Insgesamt verspricht das Studium des Glycoprotein-Stoffwechsels damit für viele klinische Bereiche neue Ansätze für pathobiochemische, diagnostische und therapeutische Fragestellungen.
    Notes: Summary Increasing knowledge on structure, biosynthesis and catabolism of glycoproteins have given new insights on the pathobiochemical and clinical significance of these macromolecules. The most important results and conclusions are summarized here. For part I of this review see Klin. Wochenschr. 1. Glycoconjugates of the erythrocyte membrane are mainly responsible for the antigenic behaviour and the half-life of these cells. Pathological alterations of the glycoprotein pattern have been found in cases of anemia. Several findings suggest that certain types of hemostatic impairment can be ascribed to changes of the glycoprotein composition of both the platelets and the clotting factors. 2. Terminal sugars determine the half-life of circulating glycoproteins. The observed changes of the glycoprotein concentration and enzyme activity in the serum of patients with liver diseases can be partly attributed to a disturbed glycosylation within the liver cell. Lectin-like proteins of the plasma membrane are probably involved in the development of hepatic diseases. 3. Bronchopulmonary diseases are quite often accompanied by changes in the amount and composition of glycoproteins secreted, a finding which might be important when elucidating the pathobiochemical mechanism. 4. Recently, substantial interest has been generated by findings of a structure-dependent function of glycoproteins within the genital tract. It is known that terminal sugars influence the acceptor-receptor specificity of several hormones released by the hypophysis. 5. The function of terminal sugar residues during the process of contact finding and the excitation transmission between neurons is well-established. Congenital or acquired diseases of the central nervous system, either benignant or malignant, often exhibit pathologic alterations of the glycoprotein pattern and the activity of glycosyltransferases or glycosidases. Taken together studies on glycoprotein metabolism may shed new light on pathogenesis, diagnosis and treatment of many diseases.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 180 (1976), S. 47-71 
    ISSN: 1432-041X
    Keywords: Annelida ; Nereidae ; Endocrinology ; Control of regeneration ; Annelida ; Nereidae ; Endokrinologie ; Regenerations-steuerung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung 1. Beim PolychaetenPlatynereis dumerilii wurde der hormonbildende Bereich des Prostomiums experimentell durch Prostomiumdurchschneidungs- und Implantationsversuche eingegrenzt. Das fragliche Areal liegt innerhalb der beiden Augenpaare und erstreckt sich vom Hinterrand der Vorderaugen bis etwa zum Hinterrand der Hinteraugen. Dies entspricht ungefähr dem Bereich des Gehirns der zwischen dem vorderen und dem hinteren, das Gehirn dorsoventral durchziehenden Bindegewebsstrang liegt und der ventral vom Epithel des Infracerebralkomplexes überzogen ist. 2. Als mögliche Bildungsorte für das Gehirnhormon werden in Betracht gezogen: (a) der Infracerebralkomplex, (b) neurosekretorische Neurone im Gehirn. 3. Der Infracerebralkomplex vonPl. dumerilii wurde licht- und elektronenoptisch untersucht. Ein im Umriß blattförmiges, maximal 120×95 μm messendes Feld des Epithels, das die Gehirnkapsel an der Ventralseite des Gehirns außen bedeckt und das dem Hauptblutgefäß und seinen beiden abführenden Ästen benachbart ist, besteht aus höheren, spezialisierten Epithelzellen. Elektronenoptisch können zwei Zelltypen unterschieden werden: die überwiegendena-Zellen und die seltenerenb-Zellen. Aus dem Neuropilem nach ventral ziehenden Faserzüge mit Gliafasern sowie z.T. neurosekretorischen Axonen enden (teilweise mit ausgeprägten Endstrukturen) an der Innenseite der Gehirnkapsel. Einige Axone durchdringen diese möglicherweise, um mit den spezialisierten Epithelzellen in Kontakt zu treten. Weder schlüssige strukturelle noch experimentelle Befunde weisen die Infracerebraldrüse als eigenständige “Gehirnhormondrüse” aus. Verschiedene akzessorische Funktionen werden diskutiert. 4. Untersuchungen an neurosekretorischen Gehirnzellen beiPl. dumerilii werden vorgelegt. Danach besteht Übereinstimmung mit Müller (1973) darin, daß eine bemerkenswerte Inkongruenz der Anzahl färberisch nachweisbarer, neurosekretorischer Neurone und der experimentell ermittelten hormonalen Aktivität der betreffenden Tiere besteht: so sind bei jungen, unreifen Individuen, denen hohe Hormontiter zugeschrieben werden, wenige, z.T. gar keine neurosekretorischen Neurone erkennbar. Unter Bezugnahme auf die Prostomiumdurchschneidungs- und Implantationsversuche ist weiter festzustellen, daß nicht in allen Gehirnbereichen, in denen neurosekretorische Zellen vorkommen, Fähigkeit zur Hormonbildung zukommt. Die Resultate werden im Hinblick auf die Thesen von Müller (1973) erörtert, denenzufolge das Auftreten färbbarer Neurosekrete als Indiz für die Inaktivierung möglicherweise zuvor hormonbildender Neurone gewertet werden kann.
    Notes: Summary 1. In the polychaetePlatynereis dumerilii, the hormone-elaborating portion of the prostomium was determined by means of prostomium transection and implantation experiments. The area in question lies between the two pairs of eyes, extending longitudinally from the posterior border of the anterior eyes to about the posterior border of the posterior eyes. This corresponds approximately with the brain area delimited by the anterior and posterior dorsoventral connective tissue tubes and which is covered ventrally by the infracerebral gland epithelium. 2. The infracerebral gland-complex and neurosecretory neurons within the brain were envisaged as possible sites of hormone synthesis. 3. The infracerebral gland-complex inPl. dumerilii was investigated with light—and electron-microscopical techniques. A leaf-shaped area (measuring 120 by 95 μm at the most) of the pericapsular epithelium at the ventral side of the brain, adjacent to the main blood vessel and to its efferent branches, consists of specialized columnar epithelial cells. Numerousa-cells and scarceb-cells can be distinguished. Fibre tracts with glia fibres and axons (some being neurosecretory axons) descend from the neuropile and in part terminate with prominent end-structures at the inner face of the brain capsule in the gland region. Probably some axons penetrate the capsule and make contact with the gland cells. Neither structural nor experimental findings prove that the infracerebral gland synthesizes the brain hormone. Accessory functions are discussed. 4. Investigations in secretory brain cells ofPl. dumerilii are reported. In agreement with Müller (1973), a lack of correlation between the number of stainable neurosecretory neurons and the hormonal activity of the brain was found: in immature worms (to which high hormonal titers are ascribed) only few or even no neurosecretory brain cells at all were detectable. Prostomium transection and implantation experiments show further that not all regions of the brain which enclose neurosecretory neurons produce brain hormone. The results are discussed with reference to the hypotheses of Müller (1973) which suggest that the appearance of stainable neurosecretory brain cells indicates inactivation of neurons possibly previously involved with hormone synthesis.
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  • 3
    Journal cover
    Online Resource
    Springer | Urban & Vogel
    licenced Journals Online: 9(6)2009 – (Go to Journal)
    licenced Journals Online: 9(6)2009 – (Go to Journal)
    Publisher: Springer , Urban & Vogel
    Print ISSN: 1617-4933
    Electronic ISSN: 1618-3851
    Topics: Medicine
    Keywords: Allgemeine medizinische Zeitschriften
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  • 4
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    Springer
    licenced Journals Online: 1.1991 – (Go to Journal)
    licenced Journals Online: 12(1)1997 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 0939-4451
    Electronic ISSN: 1438-2199
    Topics: Medicine
    Keywords: Labormedizin
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  • 5
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    Springer | Italian Society of Endocrinology
    licenced Journals Online: 20(1)1997 – (Go to Journal)
    licenced Journals Online: 20(1)1997 – (Go to Journal)
    Publisher: Springer , Italian Society of Endocrinology
    Print ISSN: 0391-4097
    Electronic ISSN: 1720-8386
    Topics: Medicine
    Keywords: Endokrinologie
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  • 6
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    Online Resource
    Springer
    partly licensed Journals Online: 1.1971 – 30(4)2000 (Go to Journal)
    Publisher: Springer
    Print ISSN: 0940-5437
    Electronic ISSN: 1434-4467
    Topics: Medicine
    Keywords: Labormedizin
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  • 7
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    Springer | PubMed Central | Association of Clinical Biochemists of India
    licenced Journals Online: 12(1)1997 – (Go to Journal)
    licenced Journals Online: 12(1)1997 – (Go to Journal)
    free Journals Online: 17.2002 – (Not the last 12 months) (Go to Journal)
    Publisher: Springer , PubMed Central , Association of Clinical Biochemists of India
    Print ISSN: 0970-1915
    Electronic ISSN: 0974-0422
    Topics: Medicine
    Keywords: Labormedizin ; Biomedizin
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  • 8
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    Springer
    licenced Journals Online: 1.1967 – (Go to Journal)
    licenced Journals Online: 60(1)1997 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 0944-0747 , 0171-967X , 0944-081X , 0008-0594
    Electronic ISSN: 1432-0827
    Topics: Physics , Biology , Medicine
    Keywords: Orthopädie ; Endokrinologie ; Zellbiologie
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  • 9
    Online Resource
    Online Resource
    BioMed Central | Springer
    free Journals Online: 1(1)2015 – (Go to Journal)
    Publisher: BioMed Central , Springer
    Electronic ISSN: 2055-8260
    Topics: Medicine
    Keywords: Endokrinologie ; Diabetologie
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  • 10
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    Birkhäuser | Springer | Seals | European Mathematical Society (EMS)
    free Journals Online: 1.1929 – (Not the last 60 months) (Go to Journal)
    partly licensed Journals Online: 1.1929 – 77.2002 (Go to Journal)
    partly licensed Journals Online: 72(1)1997 – (Not the current year) (Go to Journal)
    Publisher: Birkhäuser , Springer , Seals , European Mathematical Society (EMS)
    Print ISSN: 0010-2571
    Electronic ISSN: 1420-8946
    Topics: Mathematics
    Keywords: Allgemeine medizinische Zeitschriften ; Allgemeine mathematische Zeitschriften
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  • 11
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    Springer
    licenced Journals Online: 40(1)1997 – (Go to Journal)
    licenced Journals Online: 40(1)1997 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 1436-9990
    Electronic ISSN: 1437-1588
    Topics: Medicine
    Keywords: Allgemeine medizinische Zeitschriften ; Krankenhauswesen ; Pharmazie ; Pharmakologie ; Gesundheitswesen ; Medizinrecht ; Krankenpflege
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  • 12
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    Springer
    licenced Journals Online: 9.1836 – 28.1845 (Go to Journal)
    licenced Journals Online: 1.1920 – 3.1922 (Go to Journal)
    Publisher: Springer
    Print ISSN: 0790-231X
    Topics: Medicine
    Keywords: Allgemeine medizinische Zeitschriften ; Allgemeine medizinische Zeritschriften
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  • 13
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    Online Resource
    Nature Publishing Group
    free Journals Online: 1.2011 – (Not the last 6 months) (Go to Journal)
    Publisher: Nature Publishing Group
    Print ISSN: 2046-2166
    Electronic ISSN: 2046-2174
    Topics: Medicine
    Keywords: Endokrinologie
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  • 14
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    Springer
    licenced Journals Online: 1(1)2001 – (Go to Journal)
    licenced Journals Online: 1(1)2001 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 1591-8890
    Electronic ISSN: 1591-9528
    Topics: Medicine
    Keywords: Labormedizin
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  • 15
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    Springer
    licenced Journals Online: 26.1993 – (Go to Journal)
    licenced Journals Online: 30(1)1997 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 0918-4287 , 1860-1480
    Electronic ISSN: 1437-773X , 1860-1499
    Topics: Medicine
    Keywords: Labormedizin ; Molekularbiologie
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  • 16
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    Springer
    licenced Journals Online: 148(1)2006 – (Go to Journal)
    licenced Journals Online: 148(1)2006 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 1438-3276 , 0341-3098
    Electronic ISSN: 1613-3560
    Topics: Medicine
    Keywords: Allgemeine medizinische Zeitschriften
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  • 17
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    British Dental Association | Nature Publishing Group
    free Journals Online: 2015 – (Go to Journal)
    Publisher: British Dental Association , Nature Publishing Group
    Electronic ISSN: 2056-807X
    Topics: Medicine
    Keywords: Allgemeine medizinische Zeitschriften
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  • 18
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    Springer | früher: Humana Press
    licenced Journals Online: 8(1)1997 – (Go to Journal)
    licenced Journals Online: 8(1)1997 – (Go to Journal)
    Publisher: Springer , früher: Humana Press
    Print ISSN: 1046-3976
    Electronic ISSN: 1559-0097
    Topics: Medicine
    Keywords: Endokrinologie ; Pathologie
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  • 19
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    Springer
    licenced Journals Online: 1.1913 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 0372-8722 , 0300-9130 , 0044-2534
    Electronic ISSN: 1433-8580
    Topics: Medicine
    Keywords: Labormedizin
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  • 20
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    Nature Publishing Group
    free Journals Online: 21.1997 – (Not the last 5 years) (Go to Journal)
    Publisher: Nature Publishing Group
    Print ISSN: 0307-0565
    Electronic ISSN: 1476-5497
    Topics: Medicine
    Keywords: Endokrinologie
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  • 21
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    Springer | Hellenic Endocrine Soc.
    free Journals Online: 1(1)2002 – 16(4)2017 (Go to Journal)
    licenced Journals Online: 7.2008 – (Go to Journal)
    Publisher: Springer , Hellenic Endocrine Soc.
    Print ISSN: 1109-3099 , 2520-8721
    Electronic ISSN: 1109-3099 , 2520-8721
    Topics: Medicine
    Keywords: Endokrinologie
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  • 22
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    Springer
    licenced Journals Online: 1(1)2007 – (Go to Journal)
    licenced Journals Online: 1(1)2007 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 2095-0217 , 1673-7342
    Electronic ISSN: 2095-0225
    Topics: Medicine
    Keywords: Allgemeine medizinische Zeitschriften
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  • 23
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    Springer
    licenced Journals Online: 153(1)2003 – (Go to Journal)
    licenced Journals Online: 153(1)2003 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 0043-5341 , 0254-7945
    Electronic ISSN: 1563-258X
    Topics: Medicine
    Keywords: Allgemeine medizinische Zeitschriften
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  • 24
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    Springer
    licenced Journals Online: 166(1)1997 – (Go to Journal)
    licenced Journals Online: 166(1)1997 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 0021-1265
    Electronic ISSN: 1863-4362
    Topics: Medicine
    Keywords: Allgemeine medizinische Zeitschriften
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  • 25
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    Springer
    licenced Journals Online: 115(1)2003 – (Go to Journal)
    licenced Journals Online: 115(1)2003 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 0043-5325
    Electronic ISSN: 1613-7671
    Topics: Medicine
    Keywords: Allgemeine medizinische Zeitschriften
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  • 26
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    Nature Publishing Group
    partly licensed Journals Online: 1.1995 – 15.2009 (Go to Journal)
    Publisher: Nature Publishing Group
    Print ISSN: 1078-8956
    Electronic ISSN: 1546-170X
    Topics: Biology , Medicine
    Keywords: Allgemeine medizinische Zeitschriften
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  • 27
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    Springer | via China Academic Journals (CAJ) | Huazhong University of Science and Technology
    licenced Journals Online: 1(1)1981 – (Go to Journal)
    licenced Journals Online: 1994 – (Go to Journal)
    licenced Journals Online: 17(1)1997 – (Go to Journal)
    Publisher: Springer , via China Academic Journals (CAJ) , Huazhong University of Science and Technology
    Print ISSN: 0510-9752 , 1672-0733 , 0257-716X , 2096-5230
    Electronic ISSN: 2523-899X , 1993-1352
    Topics: Medicine
    Keywords: Allgemeine medizinische Zeitschriften
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  • 28
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    Online Resource
    Springer | ANNO
    free Journals Online: 1.1851 – 92.1944 (Go to Journal)
    Publisher: Springer , ANNO
    Print ISSN: 0043-5341
    Topics: Medicine
    Keywords: Allgemeine medizinische Zeitschriften
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  • 29
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    Springer
    licenced Journals Online: 2002 – (Go to Journal)
    licenced Journals Online: 2002 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 1610-2894
    Electronic ISSN: 1610-2908
    Topics: Medicine
    Keywords: Gynäkologie und Geburtshilfe ; Endokrinologie
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  • 30
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    Springer | Lavoisier
    licenced Journals Online: 1(1)2006 – (Go to Journal)
    Publisher: Springer , Lavoisier
    Print ISSN: 1951-5995
    Electronic ISSN: 1951-6002
    Topics: Medicine
    Keywords: Allgemeine medizinische Zeitschriften
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  • 31
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    Springer
    licenced Journals Online: 1(1)1998 – (Go to Journal)
    licenced Journals Online: 1(1)1998 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 1386-341X
    Electronic ISSN: 1573-7403
    Topics: Medicine
    Keywords: Endokrinologie
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  • 32
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    Springer
    licenced Journals Online: 1(1)2006 – (Go to Journal)
    licenced Journals Online: 1(1)2006 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 1557-1955
    Electronic ISSN: 1557-1963
    Topics: Medicine
    Keywords: Labormedizin
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  • 33
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    Springer
    licenced Journals Online: 1(1)2000 – (Go to Journal)
    licenced Journals Online: 1(1)2000 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 1590-170X
    Electronic ISSN: 1720-8351
    Topics: Medicine
    Keywords: Endokrinologie
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  • 34
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    Springer
    licenced Journals Online: 1(1)1999 – (Go to Journal)
    licenced Journals Online: 1(1)1999 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 1096-4045 , 1557-1912
    Electronic ISSN: 1557-1920 , 1573-3629
    Topics: Medicine
    Keywords: Allgemeine medizinische Zeitschriften ; Sozialmedizin
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  • 35
    Online Resource
    Online Resource
    Hindawi | PubMed Central | Springer
    free Journals Online: 2009 – (Go to Journal)
    Publisher: Hindawi , PubMed Central , Springer
    Print ISSN: 1687-9848
    Electronic ISSN: 1687-9856
    Topics: Medicine
    Keywords: Endokrinologie ; Kinderheilkunde
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  • 36
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    Springer
    partly licensed Journals Online: 7(1)2011 – 14.2018 (Go to Journal)
    Publisher: Springer
    Print ISSN: 1825-859X
    Electronic ISSN: 2039-6821
    Topics: Medicine
    Keywords: Labormedizin
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  • 37
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    Springer
    licenced Journals Online: 1(1)2008 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 1178-1653
    Electronic ISSN: 1178-1661
    Topics: Medicine
    Keywords: Allgemeine medizinische Zeitschriften
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  • 38
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    Nature Publishing Group
    partly licensed Journals Online: 1.2003 – 7.2009 (Go to Journal)
    Publisher: Nature Publishing Group
    Print ISSN: 1740-1526
    Electronic ISSN: 1740-1534
    Topics: Biology , Medicine
    Keywords: Labormedizin ; Mikrobiologie
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  • 39
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    Nature Publishing Group
    partly licensed Journals Online: 1.2005 – 5.2009 (Go to Journal)
    Publisher: Nature Publishing Group
    Print ISSN: 1745-8366 , 1759-5029
    Electronic ISSN: 1759-5037 , 1745-8374
    Topics: Medicine
    Keywords: Endokrinologie
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  • 40
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    Springer
    licenced Journals Online: 1.1886 – (Go to Journal)
    licenced Journals Online: 185(4)1997 – (Go to Journal)
    Publisher: Springer
    Print ISSN: 0340-1782 , 2199-2983 , 0044-3077 , 0300-8584
    Electronic ISSN: 1432-1831
    Topics: Medicine
    Keywords: Labormedizin ; Immunologie
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  • 41
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    Springer
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    Electronic ISSN: 1435-4373
    Topics: Medicine
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    Publisher: Springer , Krause & Pachernegg
    Print ISSN: 1995-6924
    Electronic ISSN: 2520-8500
    Topics: Medicine
    Keywords: Gynäkologie und Geburtshilfe ; Endokrinologie
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