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  • Organic Chemistry  (68,967)
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  • 1
    Online Resource
    Online Resource
    Wiesbaden : Springer Spektrum
    Keywords: Chemistry, Organic ; Catalysis ; Organic Chemistry ; Catalysis ; Hochschulschrift
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (X, 129 S. 143 Abb., 16 Abb. in Farbe)
    ISBN: 9783658246082
    Series Statement: BestMasters
    Uniform Title: Synthese und Evaluierung neuartiger Carbenliganden für die (enantio)selektive Hydrierung von Aromaten
    DDC: 547
    Language: German
    Dissertation note: Masterarbeit Westfälische Wilhelms-Universität Münster
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  • 2
    Online Resource
    Online Resource
    Berlin : Springer
    Keywords: Koordinationslehre ; Homogene Katalyse ; Metallorganische Verbindungen ; Chemistry, inorganic ; Chemistry, Organic ; Inorganic Chemistry ; Organic Chemistry ; Koordinationslehre ; Homogene Katalyse ; Metallorganische Verbindungen
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XVI, 528 S. 99 Abb., 50 Abb. in Farbe)
    Edition: 3., überarbeitete und erweiterte Auflage
    ISBN: 9783662566046
    Series Statement: Studienbücher Chemie
    DDC: 546
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    Language: German
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  • 3
    Online Resource
    Online Resource
    Berlin : Springer Spektrum
    Keywords: Brandbekämpfung ; Chemie ; Chemicals / Safety measures ; Fire prevention ; Chemistry, Physical organic ; Chemistry, Organic ; Chemistry, inorganic ; Nuclear chemistry ; Safety in Chemistry, Dangerous Goods ; Fire Science, Hazard Control, Building Safety ; Physical Chemistry ; Organic Chemistry ; Inorganic Chemistry ; Nuclear Chemistry ; Brandbekämpfung ; Chemie
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XIX, 736 S. 300 Abb., 277 Abb. in Farbe)
    ISBN: 9783662566060
    DDC: 604.7
    Language: German
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  • 4
    Online Resource
    Online Resource
    Wiesbaden : Springer Spektrum
    Keywords: Chemistry, Organic ; Catalysis ; Organic Chemistry ; Catalysis ; Hochschulschrift
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XIV, 101 S. 1 Abb)
    ISBN: 9783658252311
    Series Statement: BestMasters
    Uniform Title: Addition von Radikalen an Carbonyle durch Photokatalyse mit sichtbarem Licht
    DDC: 547
    Language: German
    Dissertation note: Masterarbeit Westfälische WilhelmsUniversität Münster 2017
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  • 5
    Online Resource
    Online Resource
    Berlin, Heidelberg : Springer Berlin Heidelberg | Berlin, Heidelberg : Springer Spektrum
    Keywords: Chemieunterricht ; Didaktik ; Chemistry, Organic ; Analytical biochemistry ; Science / Study and teaching ; Organic Chemistry ; Analytical Chemistry ; Learning & Instruction ; Science Education ; Teaching and Teacher Education ; Chemieunterricht ; Didaktik
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (IX, 271 S. 48 Abb., 26 Abb. in Farbe)
    ISBN: 9783662586457
    DDC: 547
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    Language: German
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  • 6
    Online Resource
    Online Resource
    Berlin, Heidelberg : Springer Berlin Heidelberg | Berlin, Heidelberg : Springer Spektrum
    Person(s): Schwedt, Georg
    Keywords: Chemistry, inorganic ; Chemistry-History ; Chemistry, Organic ; Chemistry, Physical organic ; Chemicals / Safety measures ; Inorganic Chemistry ; History of Chemistry ; Organic Chemistry ; Physical Chemistry ; Safety in Chemistry, Dangerous Goods
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (VI, 91 S. 20 Abb., 4 Abb. in Farbe)
    Edition: 1st ed. 2019
    ISBN: 9783662579862
    DDC: 546
    Language: German
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  • 7
    Online Resource
    Online Resource
    Wiesbaden : Springer Fachmedien Wiesbaden | Wiesbaden : Springer Spektrum
    Person(s): Hecht, Thomas
    Keywords: Spectroscopy ; Chemistry, Organic ; Chemistry, inorganic ; Chemistry, Physical organic ; Spectroscopy ; Organic Chemistry ; Inorganic Chemistry ; Physical Chemistry
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (VIII, 46 S. 25 Abb., 1 Abb. in Farbe)
    Edition: 1st ed. 2019
    ISBN: 9783658275358
    Series Statement: essentials
    DDC: 543.2-543.8
    Language: German
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  • 8
    Online Resource
    Online Resource
    Berlin : Springer Spektrum
    Keywords: Analytical biochemistry ; Chemistry, Organic ; Analytical Chemistry ; Organic Chemistry ; Spectroscopy and Microscopy
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (VIII, 131 S. 61 Abb., 15 Abb. in Farbe)
    ISBN: 9783662586358
    DDC: 543
    Language: German
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  • 9
    Online Resource
    Online Resource
    Wiesbaden : Springer Spektrum
    Keywords: Fotokatalyse ; Fotochemie ; Chemistry, Organic ; Catalysis ; Organic Chemistry ; Catalysis ; Hochschulschrift ; Fotokatalyse ; Fotochemie
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XIV, 115 S. 23 Abb., 10 Abb. in Farbe)
    ISBN: 9783658263188
    Series Statement: BestMasters
    Uniform Title: Verwendung neuartiger Quencher zur Entwicklung photokatalytischer Reaktionen inspiriert durch mechanismusbasiertes Screening
    DDC: 547
    Language: German
    Dissertation note: Masterarbeit Westfälische Wilhelms-Universität Münster 2017
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  • 10
    Online Resource
    Online Resource
    Berlin : Springer Spektrum
    Keywords: Chemisches Labor ; Chemistry ; Pharmacy ; Analytical chemistry ; Organic chemistry ; Medicine ; Microbiology ; Chemistry ; Analytical Chemistry ; Organic Chemistry ; Pharmacy ; Medicine ; Microbiology ; Mehrsprachiges Wörterbuch ; Chemisches Labor
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XII, 546 S. 1 Abb)
    Edition: 3. Auflage
    ISBN: 9783662558485
    DDC: 503
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    Language: German
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  • 11
    Online Resource
    Online Resource
    Wiesbaden : Springer Spektrum
    Keywords: Molekularbiologie ; Molekularbiologische Methode ; Life sciences ; Cytogenetics ; Organic chemistry ; Biochemistry ; Microbiology ; Electrophoresis ; Life Sciences ; Microbiology ; Organic Chemistry ; Electrophoresis ; Biochemistry, general ; Cytogenetics ; Molekularbiologie ; Molekularbiologische Methode
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XII, 83 S. 63 Abb., 4 Abb. in Farbe)
    Edition: 2., überarbeitete Auflage
    ISBN: 9783658206246
    Series Statement: essentials
    DDC: 579
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    Language: German
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  • 12
    Online Resource
    Online Resource
    Berlin : Springer
    Keywords: Giftpflanzen ; Gartenpflanzen ; Giftpflanzen ; Deutschland ; Mitteleuropa ; Popular works ; Organic chemistry ; Plant science ; Botany ; Nature ; Environment ; Popular Science ; Popular Science in Nature and Environment ; Plant Sciences ; Organic Chemistry ; Environment, general ; Deutschland 03.10.1990- ; Giftpflanzen ; Gartenpflanzen ; Mitteleuropa ; Giftpflanzen
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XII, 256 S. 69 Abb. in Farbe)
    Edition: 2. Auflage
    ISBN: 9783662560488
    DDC: 333.7
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    Language: German
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  • 13
    Online Resource
    Online Resource
    Berlin : Springer Spektrum
    Keywords: Chemie ; Englisch ; Chemie ; Deutsch ; Chemistry ; Analytical chemistry ; Inorganic chemistry ; Organic chemistry ; Physical chemistry ; Polymers ; Chemical engineering ; Chemistry ; Analytical Chemistry ; Inorganic Chemistry ; Organic Chemistry ; Physical Chemistry ; Polymer Sciences ; Industrial Chemistry ; Mehrsprachiges Wörterbuch ; Wörterbuch ; Chemie ; Englisch ; Chemie ; Deutsch
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (IX, 438 S.)
    Edition: 2., überarbeitete und erweiterte Auflage
    ISBN: 9783662563311
    DDC: 540.3
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    Language: German
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  • 14
    Online Resource
    Online Resource
    Berlin : Springer Spektrum
    Person(s): Ritter, Helmut
    Keywords: Makromolekulare Chemie ; Chemistry ; Organic chemistry ; Polymers ; Biomaterials ; Chemistry ; Polymer Sciences ; Organic Chemistry ; Biomaterials ; Lehrbuch ; Makromolekulare Chemie
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (VII, 226 S. 136 Abb)
    ISBN: 9783662559567
    DDC: 541.2254
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    Language: German
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  • 15
    Online Resource
    Online Resource
    Wiesbaden : Springer Spektrum
    Keywords: Chemie ; Naturstoff ; Biomolekül ; Chemistry ; Organic chemistry ; Organic Chemistry ; Naturstoff ; Biomolekül
    Type of Medium: Online Resource
    Pages: 1 Online Ressource (IX, 55 Seiten)
    ISBN: 9783658154394 , 9783658154387
    Series Statement: essentials
    DDC: 547
    Language: German
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  • 16
    Online Resource
    Online Resource
    Berlin : Springer Spektrum
    Keywords: Organische Verbindungen ; Chemistry, Organic ; Organic Chemistry ; Lehrbuch ; Organische Verbindungen
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XIII, 188 S. 176 Abb)
    ISBN: 9783662549681
    DDC: 547
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    Language: German
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  • 17
    Online Resource
    Online Resource
    Wiesbaden : Springer Spektrum
    Keywords: Chemie ; Chemistry ; Spectroscopy ; Organic chemistry ; Organic Chemistry ; Spectroscopy ; Hochschulschrift
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XV, 129 Seiten)
    ISBN: 9783658172664
    Series Statement: BestMasters
    DDC: 547
    Language: German
    Dissertation note: Masterarbeit Westfälische Wilhelms-Universität Münster
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  • 18
    Online Resource
    Online Resource
    Berlin : Springer Spektrum
    Keywords: Chemie ; Ingenieurwissenschaften ; Wirtschaft ; Chemistry ; Business ; Management science ; Inorganic chemistry ; Organic chemistry ; Physical chemistry ; Engineering ; Chemistry ; Inorganic Chemistry ; Organic Chemistry ; Physical Chemistry ; Engineering, general ; Business and Management, general
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XXVII, 631 Seiten)
    ISBN: 9783662528211
    DDC: 546
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    Language: German
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  • 19
    Online Resource
    Online Resource
    Berlin : Springer Spektrum
    Person(s): Gey, Manfred
    Keywords: Chemie ; Analytische Chemie ; Biochemische Analyse ; Methode ; Praktikum ; Chemistry ; Analytical chemistry ; Biotechnology ; Food ; Organic chemistry ; Biochemistry ; Analytical Chemistry ; Biochemistry, general ; Organic Chemistry ; Food Science ; Analytische Chemie ; Biochemische Analyse ; Methode ; Praktikum
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XVII, 309 Seiten 304 Abb)
    ISBN: 9783662541234
    DDC: 543
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    Language: German
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  • 20
    Online Resource
    Online Resource
    Berlin : Springer Spektrum
    Keywords: Chemie ; Chemistry ; Organic chemistry ; Organic Chemistry
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (X, 387 Seiten)
    ISBN: 9783662538524
    DDC: 547
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    Language: German
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  • 21
    Online Resource
    Online Resource
    Berlin [u.a.] : Springer Spektrum
    Associated volumes
    Keywords: Chemie ; Organische Chemie ; Chemistry ; Analytical chemistry ; Organic chemistry ; Organic Chemistry ; Analytical Chemistry ; Lehrbuch ; Organische Chemie
    Type of Medium: Online Resource
    Pages: 1 Online Ressource (XXIV, 629 S. 91 Abb)
    Edition: 7. Aufl.
    ISBN: 9783662461808 , 9783662461792
    Series Statement: Chemie-Basiswissen 2
    DDC: 547
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    Language: German
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  • 22
    Online Resource
    Online Resource
    Wiesbaden : Springer Spektrum
    Person(s): Rakers, Lena
    Keywords: Chemie ; Chemistry ; Organic chemistry ; Medicinal chemistry ; Catalysis ; Organic Chemistry ; Medicinal Chemistry ; Hochschulschrift
    Type of Medium: Online Resource
    Pages: 1 Online Ressource (X, 124 S. 50 Abb)
    ISBN: 9783658125806 , 9783658125790
    Series Statement: BestMasters
    DDC: 547
    Language: German
    Dissertation note: Masterarbeit Westfälische Wilhelms-Universität Münster 2016
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  • 23
    Online Resource
    Online Resource
    Wiesbaden : Springer Spektrum
    Keywords: Chemie ; Chemistry ; Organic chemistry ; Medicinal chemistry ; Catalysis ; Organic Chemistry ; Medicinal Chemistry ; Hochschulschrift
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XII, 108 Seiten 142 Abb)
    ISBN: 9783658126919 , 9783658126902
    Series Statement: BestMasters
    DDC: 541.395
    Language: German
    Dissertation note: Masterarbeit Westfälische Wilhelms-Universität Münster
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  • 24
    Online Resource
    Online Resource
    Berlin [u.a.] : Springer Spektrum
    Keywords: Giftpflanzen ; Gartenpflanzen ; Mitteleuropa ; Deutschland ; Popular works ; Organic chemistry ; Plant science ; Botany ; Nature ; Environment ; Popular Science ; Popular Science in Nature and Environment ; Plant Sciences ; Organic Chemistry ; Environment, general ; Mitteleuropa ; Giftpflanzen ; Gartenpflanzen ; Deutschland 03.10.1990-
    Type of Medium: Online Resource
    Pages: 1 Online Ressource (IX, 207 S. 57 Abb. in Farbe)
    ISBN: 9783662471906 , 9783662471890
    DDC: 500
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    Language: German
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  • 25
    Online Resource
    Online Resource
    Wiesbaden : Springer Spektrum
    Person(s): Geibel, Irina
    Keywords: Chemie ; Chemistry ; Organic chemistry ; Chemical engineering ; Catalysis ; Organic Chemistry ; Industrial Chemistry ; Hochschulschrift
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XIV, 76 Seiten 57 Abb)
    ISBN: 9783658128036 , 9783658128029
    Series Statement: BestMasters
    DDC: 547
    Language: German
    Dissertation note: Masterarbeit Carl von Ossietzky Universität Oldenburg 2014
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  • 26
    Online Resource
    Online Resource
    Wiesbaden : Springer Spektrum
    Keywords: Chemie ; Chemistry ; Inorganic chemistry ; Organic chemistry ; Catalysis ; Inorganic Chemistry ; Organic Chemistry ; Hochschulschrift
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XXIII, 133 Seiten 54 Abb)
    ISBN: 9783658135744 , 9783658135737
    Series Statement: BestMasters
    DDC: 541.395
    Language: German
    Dissertation note: Masterarbeit Technische Universität München
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  • 27
    Online Resource
    Online Resource
    Wiesbaden : Springer Fachmedien Wiesbaden
    Person(s): Massa, Werner
    Keywords: Chemie ; Kristallstrukturanalyse ; Chemistry ; Chemistry, inorganic ; Chemistry, Organic ; Mineralogy ; Biochemistry ; Materials ; Inorganic Chemistry ; Organic Chemistry ; Biochemistry, general ; Structural Materials ; Lehrbuch ; Kristallstrukturanalyse
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XII, 243 S. 109 Abb)
    Edition: 8., überarb. Aufl.
    ISBN: 9783658094126 , 9783658094119
    Series Statement: Studienbücher Chemie
    DDC: 546
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    Language: German
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  • 28
    Online Resource
    Online Resource
    Wiesbaden : Springer Fachmedien Wiesbaden
    Keywords: Chemie ; Aromaten ; Katalytische Hydrierung ; Asymmetrische Reaktion ; Katalysator ; Rutheniumkomplexe ; Heterocyclische Carbene (-N) ; Chemistry ; Chemistry, Organic ; Biochemistry ; Catalysis ; Organic Chemistry ; Medicinal Chemistry ; Hochschulschrift ; Aromaten ; Katalytische Hydrierung ; Asymmetrische Reaktion ; Katalysator ; Rutheniumkomplexe ; Heterocyclische Carbene 〈-N〉
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XIII, 85 S. 16 Abb)
    ISBN: 9783658089672 , 9783658089665
    Series Statement: BestMasters
    DDC: 547
    RVK:
    Language: German
    Dissertation note: Zugl.: Münster, Univ., Masterarbeit
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  • 29
    Online Resource
    Online Resource
    Wiesbaden : Springer Fachmedien
    Keywords: Chemie ; Organische Chemie ; Chemistry ; Chemistry, Organic ; Catalysis ; Organic Chemistry ; Chemistry ; Hochschulschrift ; Organische Chemie
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XIII, 101 S.) , graph. Darst.
    ISBN: 9783658094089 , 9783658094072
    Series Statement: BestMasters
    DDC: 547
    Language: German
    Dissertation note: Zugl.: Hannover, Univ., Masterarbeit
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  • 30
    Online Resource
    Online Resource
    Wiesbaden : Springer Fachmedien Wiesbaden
    Keywords: Biowissenschaften ; Molekularbiologie ; Molekularbiologische Methode ; Life sciences ; Chemistry, Organic ; Microbiology ; Electrophoresis ; Life Sciences ; Organic Chemistry ; Einführung ; Molekularbiologie ; Molekularbiologische Methode
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (VIII, 69 S. 59 Abb)
    ISBN: 9783658085377 , 9783658085360
    Series Statement: essentials
    DDC: 579
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  • 31
    Online Resource
    Online Resource
    Basel [u.a.] : Birkhäuser
    Keywords: Chemie ; Polymere ; Makromolekulare Chemie ; Kunststoff ; Chemistry ; Chemistry, inorganic ; Chemistry, Organic ; Polymers ; Atomic/Molecular Structure and Spectra ; Inorganic Chemistry ; Organic Chemistry ; Polymer Sciences ; Polymere ; Makromolekulare Chemie ; Kunststoff
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource
    Edition: 4., überarb. und erw. Aufl.
    ISBN: 9783764388904 , 9783764388911
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  • 32
    Online Resource
    Online Resource
    Heidelberg [u.a.] : Springer
    Keywords: Chemie ; NMR-Spektrum ; Datenauswertung ; NMR-Spektroskopie ; Datenauswertung ; Organische Verbindungen ; Analytical biochemistry ; Chemistry ; Chemistry, Organic ; Chemistry, Physical organic ; Analytical Chemistry ; Organic Chemistry ; Physical Chemistry ; Aufgabensammlung ; NMR-Spektrum ; Datenauswertung ; NMR-Spektroskopie ; Datenauswertung ; Organische Verbindungen
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource
    ISBN: 9783642016820 , 9783642016837
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  • 33
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 10 (1998), S. 289-293 
    ISSN: 0899-0042
    Keywords: chirality ; time reversal symmetry ; asymmetric synthesis ; enantiomerism ; isomerism ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: If a molecule is identified not only by its static spatial constructions, but also by the motions at the sub-molecular level, application of time reversal symmetry operation to a certain molecule could lead to another distinguishable from the original in the sense of sub-molecular motions, a phenomenon now defined as time reversal isomerism. Assessment of the consideration of certain enantiomers as distinguishable time reversal isomers is suggested in order to evoke a comprehensive interpretation of a likely correlation between the two types of isomerisms. The conceptual basis of a connection between absolute asymmetric synthesis under the influence of external fields and the intrinsic time reversal symmetry violation at the molecular level is also established to encourage new experimental investigations on this theme. Chirality 10:289-293, 1998. © 1998 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
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  • 34
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 10 (1998), S. 210-216 
    ISSN: 0899-0042
    Keywords: enantiospecific assay ; rat ; dog ; human ; enantiomer disposition ; HIV protease inhibitor ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: PNU-103017, 4-Cyano-N-(3-(cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta(b) pyran-3-yl)methyl)phenyl)-benzenesulfonamide, is a selective HIV aspartyl protease inhibitor under evaluation as a potential oral treatment of Acquired Immunodeficiency Diseases. PNU-103017 is a racemic mixture of two enantiomers, designated PNU-103264 (R-) and PNU-103265 (S-). Stereoselective pharmacokinetics of the two enantiomers of PNU-103017 were observed in the dog, rat, and human after single and multiple dose administration of the racemate and were apparently species-dependent. Mean enantiomeric ratios of plasma concentrations (R-/S-) at each time point were greater than 1 in the dog, ranging from 1.22 to 3.06, but less than 1 in the rat and in the human, ranging from 0.44 to 0.80 and 0.23 to 0.73, respectively. A trend towards increased or decreased (farther from 1:1, R-/S-) enantiomeric ratio of plasma concentrations with time after each administration was also observed. The enantiomeric ratio remained unchanged after multiple dose administration in the rat, dog, and human although enzyme induction and increased plasma clearance were observed for both enantiomers. Chirality 10:210-216, 1998. © 1998 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
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  • 35
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 10 (1998), S. 253-261 
    ISSN: 0899-0042
    Keywords: chiroptical properties ; Cotton effect ; atropisomerism ; quantum-mechanical calculation ; AM1 ; CNDO/S ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Rotational strengths calculated on the basis of quantum-mechanically obtained minimum energy geometries were used to determine the absolute configurations of axially chiral 3-aryl-4(3H)-quinazolinones from the sign of the observed Cotton effects (CEs). For the spectral data, CNDO/S calculations were used; for the geometries, ab initio (RHF/6-31G) and semiempirical (AM1) theories were used. Oscillator and rotational strengths of all excited states down to 200 nm were compared to experimental absorption and circular dichroism (CD) data. It was found that the sign of the 1Lb Cotton effects obtained for the enantiomers of methaqualone and derivatives of 3-aryl-2-alkylthio-4(3H)-quinazolinones can be correlated unambiguously with the absolute configuration. Furthermore, the sign of the Cotton effect of the π-π* transition of the thiocarbonyl chromophore of 3-aryl-2-mercapto-4(3H)-quinazolinones is suitable for a successful stereochemical correlation. Chirality 10:253-261, 1998. © 1998 Wiley-Liss, Inc.
    Additional Material: 9 Ill.
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  • 36
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 10 (1998), S. 283-288 
    ISSN: 0899-0042
    Keywords: chiral HPLC ; cellulose carbamates ; enantiomeric resolution ; warfarin ; flurbiprofen ; lorazepam ; oxazepam ; pindolol ; tertatolol ; nicardipine ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Four cellulose mixed 10-undecenoate/carbamate derivatives, simultaneously bearing 10-undecenoyl and variously substituted phenylaminocarbonyl groups, were chemically bonded on allylsilica gel. The study of the effect of these substitutions on the performance of the resulting chiral supports, and a comparison with the recently described 10-undecenoate/3,5-dimethylphenylcarbamate derivative, are presented. In this study heptane/2-propanol or heptane/chloroform mixtures were used as mobile phases. Chirality 10:283-288, 1998. © 1998 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
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  • 37
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 10 (1998), S. 316-320 
    ISSN: 0899-0042
    Keywords: atropisomeric polychlorinated biphenyls (PCBs) ; Chirasil-Dex ; rotational barrier ; stopped-flow multidimensional gas chromatographic technique ; on-line enantiomerization kinetics ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The rotational barriers ΔG
    Additional Material: 3 Ill.
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  • 38
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 10 (1998), S. 325-337 
    ISSN: 0899-0042
    Keywords: diastereomeric salts ; molecular recognition ; hydrogen bonding ; thermal analysis ; crystallography ; solubility ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: (+)-(1S;2S)-Pseudoephedrine and racemic mandelic acid form three distinct diastereomeric salts from solutions in 95% ethanol. The least-soluble phase, a hemihydrate, contains the (2R)-mandelate. A salt phase of intermediate solubility is the unsolvated double salt, containing both the (2R)- and the (2S)-mandelate. The most-soluble salt phase contains the (2S)-mandelate. Mandelate configuration and order of solubility (based on the heats of fusion) is inverted from that found in the same system synthesized from chiral base and acid, and then crystallized from benzene solution. The (2R)-mandelate hemihydrate (-H2O at 349.5K, mp 391K), monoclinic, P21, a = 6.788(5), b = 29.415(35), c = 9.488(10)Å, β = 108.91(8)°, Z = 4 (2 ion-pairs/asymmetric unit). Intermediate double salt (2S)- and (2R)-mandelate, mp 377.6K, anorthic, P1, a = 7.758(4), b = 9.966(5), c = 13.366(6)Å, α = 72.99(4), β = 79.98(4), γ = 70.51(4)°, Z = 1 (2 ion-pairs/asymmetric unit). The (2S)-mandelate (mp 386.2K), orthorhombic, P212121, a = 7.079(6), b = 13.443(10), c = 18.820(14)Å, Z = 4 is identical to a salt made from a combination of enantiomeric moieties from benzene solution. While differing from ephedrine mandelates in configuration at one center, solubilities of pseudoephedrine mandelates in 95% ethanol are much larger. A comparison of molecular structure (non-polar and H-bonding) regions of pseudoephedrine and ephedrine mandelates shows similarities and differences that are tentatively linked to crystal properties. This study reemphasizes the necessity for consistency in solvent use in resolution and in phase identification and comparison because the phases produced are frequently dependent upon the solvent. Chirality 10:325-337, 1998. © 1998 Wiley-Liss, Inc.
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    Chirality 10 (1998), S. 371-372 
    ISSN: 0899-0042
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: No abstract.
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  • 40
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    Chirality 10 (1998), S. 364-369 
    ISSN: 0899-0042
    Keywords: (±)nicotine ; (±)nornicotine ; chiral separation ; enantiomers ; normal phase HPLC ; mobile phase additive ; cellulose-based chiral stationary phase ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: This paper describes the enantiorecognition of (±)nicotine and (±)nornicotine by high-performance liquid chromatography using two derivatized cellulose chiral stationary phases (CSPs) operated in the normal phase mode. It was found that different substituents linked to the cellulose backbone significantly influence the chiral selectivity of the derivatized CSP. The results showed that, in general, the tris(4-methylbenzoyl) cellulose CSP (Chiralcel OJ) surpasses tris(3,5-dimethylphenyl carbamoyl) cellulose CSP (Chiralcel OD). On the former column, the resolution (±)nicotine and (±)nornicotine enantiomers depended largely on mobile phase compositions. For the separation of the nicotine enantiomers, the addition of trifluoroacetic acid to a 95:5 hexane/alcohol mobile phase greatly improved the enantioresolution, probably due to enhanced hydrogen bonding interactions between the protonated analytes and the CSP. For (±)nornicotine separation, a reduction in the concentration of alcohol in the mobile phase was more effective than the addition of trifluoroacetic acid. Possible solute-mobile phase-stationary phase interactions are discussed to explain how different additives in the mobile phase and different substituents on the cellulose glucose units of the CSPs affect the separation of both pairs of enantiomers. Chirality 10:364-369, 1998. Published 1998 Wiley-Liss, Inc.This article is a US Government work and, as such, is in the public domain in the United States of America.
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  • 41
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    Chirality 10 (1998), S. 430-433 
    ISSN: 0899-0042
    Keywords: Whelk-O 1 ; chromatography ; HPLC ; enantiodifferentiation ; heterocycles ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In concert with a larger study of the processes by which chiral stationary phase CSP 1 differentiates between enantiomers, we have investigated the chromatographic separation of the enantiomers of a series of aryl-substituted heterocycles of systematically varied structure. A mechanistic picture of how these and similar resolutions occur is emerging. The mechanistic hypothesis described herein is of predictive value. Chirality 10:430-433, 1998. © 1998 Wiley-Liss, Inc.
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    Chirality 10 (1998), S. 528-534 
    ISSN: 0899-0042
    Keywords: chiral inversion ; ibuprofen ; ketoprofen ; flurbiprofen ; indoprofen ; suprofen ; fenoprofen ; metabolism of 2-arylpropionic acids ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The fungus Cordyceps militaris has been previously shown to be capable of inverting the chirality of 2-phenylpropionic acid from its (R)-enantiomer to its (S)-antipode. The structure of this compound is similar to the 2-arylpropionic acid non-steroidal anti-inflammatory drugs, which have also been reported to undergo a similar chiral inversion process in mammals and man. We report here an investigation into the substrate specificity of the enzyme system present in C. militaris using pure enantiomers and racemates of ibuprofen and ketoprofen and racemates of indoprofen, suprofen, flurbiprofen, and fenoprofen and the structurally related compounds 2-phenylbutyric acid and 2-phenoxypropionic acid as substrates, using optimised incubation conditions developed for the inversion of 2-phenylpropionic acid. The results demonstrated that C. militaris is capable of inverting the chirality of all the compounds investigated, which suggests that the active sites of the enzymes are very flexible with regard to the molecular dimensions of the substrate molecule and the spatial occupation of the groups surrounding the chiral centre. Metabolism of all the substrates was observed but the rate of metabolism varied extensively depending on the substrate. Achiral HPLC analysis was used to detect any potential metabolites and the results suggested that the site of the metabolism appeared to be at the aliphatic side groups only, with the aromatic ring being left intact in all cases. These results suggest that C. militaris could be a valuable tool in the investigation of the prospective metabolic fates of new 2-arylpropionic acids during their development. Chirality 10:528-534, 1998. © 1998 Wiley-Liss, Inc.
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    Chirality 10 (1998), S. 555-555 
    ISSN: 0899-0042
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: No abstract.
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  • 44
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    Chirality 10 (1998), S. 564-572 
    ISSN: 0899-0042
    Keywords: asymmetric hydrogenation ; aminophosphine phosphinites ; rhodium complexes ; dehydro aminophosphonic acids ; NMR ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Chiral α-aminophosphonic acid derivatives are efficiently synthesized by asymmetric hydrogenation of the prochiral N-acyl-α,β-dehydroaminophosphonates. PROPRAPHOS-Rh-catalysts from readily available (S)- and (R)-Propranolol proved to be suitable in the homogenous reaction affording an enantiomeric excess of 87-92% with high rate. The aminophosphonic acid derivatives and precursors were fully characterized by 1H, 13C, and 31P NMR spectroscopy. Chirality 10:564-572, 1998. © 1998 Wiley-Liss, Inc.
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    Chirality 10 (1998), S. 592-599 
    ISSN: 0899-0042
    Keywords: chiral separation ; chiral selector ; separation of enantiomers ; liquid chromatography ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A chiral stationary phase (CSP 1) prepared starting from (R)-4-hydroxyphenylglycine and then grafting (R)-N-butanoyl-4-allyloxyphenylglycine N-propyl amide to silica gel was found to be very effective in separating the enantiomers of N-(3,5-dinitrobenzoyl)-α-amino amides. From the chromatographic behaviors of the resolution of N-propyl amides, N,N-diethyl amides and ethyl esters of N-(3,5-dinitrobenzoyl)-α-amino acids and the resolution of various N-(substituted benzoyl)leucine N-propyl amides, the hydrogen bonding and the π-π donor-acceptor sites of the analyte for the interaction with the CSP have been proposed. Similarly, the hydrogen bonding donor and acceptor sites of the CSP for the interaction with the analyte have been proposed from the comparison of the chromatographic behaviors of the resolution of various N-(3,5-dinitrobenzoyl)-α-amino N-propyl amides on modified CSPs (CSP 7 containing trifluoroacetyl group instead of the butanoyl group of CSP 1 and CSP 8 containing N,N-diethyl group instead of the N-propyl group of CSP 1) with those on CSP 1. By correlating the interaction sites of the CSP and their complementary interaction sites of the analyte, a chiral recognition mechanism which utilizes the two hydrogen bonding interactions and the π-π donor-acceptor interaction between (R)-CSP 1 and more retained analytes, (S)-N-(3,5-dinitrobenzoyl)-α-amino amides, has been proposed. Chirality 10:592-599, 1998. © 1998 Wiley-Liss, Inc.
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    Chirality 10 (1998), S. 619-626 
    ISSN: 0899-0042
    Keywords: nucleophilic aromatic substitution ; optical resolution ; asymmetric synthesis ; diastereoselective reaction ; Grignard reaction ; atrolactic acid derivatives ; biaryl coupling reaction ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Novel 1-aryl-9H-fluoren-9-ols 1 were conveniently synthesized by using the ester-mediated nucleophilic aromatic substitution on 2,6-dimethoxybenzoate 2 by aryl Grignard reagents as the key step. Racemic 1-phenylfluorenol 1a was converted to the diastereomeric esters 8 of (S)-2′-methoxy-1,1′-binaphthyl-2-carboxylic acid, which were readily separable by silica-gel column chromatography. Reduction of the optically pure diastereomer (+)-8 with LiAlH4 accompanied an appreciable racemization to give (+)-1a of 89% ee, which provides the first isolation of an optically active fluorenol of defined enantiomeric purity. Intrinsic chiral induction abilities of the 9-fluorenols 1 were examined in the atrolactic acid synthesis from phenylglyoxylates 9 and methylmagnesium iodide with diastereoselectivity of up to 85% de and the binaphthyl coupling of 1-methoxy-2-naphthoates 11 with 2-methoxy-1-naphthylmagnesium bromide with up to 73% de. Chirality 10:619-626, 1998. © 1998 Wiley-Liss, Inc.
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    Chirality 10 (1998), S. 693-698 
    ISSN: 0899-0042
    Keywords: Pseudomonas cepacia ; lipase PS ; transesterification ; kinetic resolution ; 2-substituted 3-hydroxy ester ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Kinetic resolution of 2-substituted 3-hydroxy esters was examined by lipase PS catalyzed transesterification using vinyl acetate as an acyl donor. Resolution of (±)-syn- and -anti-1a, -1e possessing a small methyl group at the C-3 position was accomplished enantioselectively. The outcome of the resolution seems to be related to the differences in size of the substituents at the stereocenter bearing a secondary hydroxy group. Chirality 10:693-698, 1998. © 1998 Wiley-Liss, Inc.
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    Chirality 10 (1998), S. 699-704 
    ISSN: 0899-0042
    Keywords: ormeloxifene ; chiral separation ; sulfated cyclodextrin ; enantiomers ; capillary electrophoresis ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: (-)-Ormeloxifene, a drug candidate under development, was separated from (+)-ormeloxifene using capillary electrophoresis (CE) with sulfated β-cyclodextrin as chiral buffer additive. With conventional long-end injection the method showed high efficiency, since the theoretical plate number for (-)-ormeloxifene was over 1 million per m and the enantiomeric resolution was more than 100. However, the relatively long separation time of ∼22 min was a limiting factor. In order to reduce separation time, short-end injection experiments were carried out. By using the instrumental limits for capillary dimensions and field strength, the separation time was reduced to 〈40 sec. A further and significant reduction was achieved by applying extended short-end injection, which is a novel injection technique presented in this paper. With the extended short-end injection procedure, a plug of run buffer is injected after the sample has been injected, thus moving the sample closer to the detector and resulting in very short effective capillary lengths. Using the extended short-end injection technique, the separation was performed on 1.8 cm capillary (effective length) and the enantiomers were separated within 10 sec, which is a reduction of the original separation time by a factor of ∼155. Chirality 10:699-704, 1998. © 1998 Wiley-Liss, Inc.
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    Chirality 10 (1998), S. iii 
    ISSN: 0899-0042
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: No abstract.
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