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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters B 294 (1992), S. 466-478 
    ISSN: 0370-2693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters B 317 (1993), S. 474-484 
    ISSN: 0370-2693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Chem. Commun. , 2019, Advance Article DOI : 10.1039/C8CC08199A, Communication Jingming Zhang, Changning Li, Jason Armstrong, Shenqiang Ren Herein, we report the eutectic growth control of ordered L1 0 -FePt, which directs the nucleation, growth and crystallization of FePt sheets in a single-step reaction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1359-7345
    Electronic ISSN: 1364-548X
    Topics: Chemistry and Pharmacology
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  • 4
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Chem. Sci. , 2019, 10 ,284-292 DOI : 10.1039/C8SC01494A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Hung-Hsun Lu, Cheng-Hung Huang, Ting-Yun Shiue, Fu-Sheng Wang, Ko-Kai Chang, Yunching Chen, Chi-How Peng Triblock copolymer, PEG- b -PDMAEMA- b -PPy, has been shown as an ideal carrier with remarkable siRNA condensation, high stability, efficient gene release, and negligible cytotoxicity for gene delivery. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 2041-6520
    Electronic ISSN: 2041-6539
    Topics: Chemistry and Pharmacology
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  • 5
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Chem. Sci. , 2019, 10 ,198-207 DOI : 10.1039/C8SC03510E, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Wei-Kai Tsai, Chun-I. Wang, Chia-Hsien Liao, Chun-Nien Yao, Tsai-Jhen Kuo, Ming-Ho Liu, Chao-Ping Hsu, Shu-Yi Lin, Chang-Yi Wu, Joseph R. Pyle, Jixin Chen, Yang-Hsiang Chan This article presents the first work to fundamentally study the effect of steric hindrance in Pdot systems. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 2041-6520
    Electronic ISSN: 2041-6539
    Topics: Chemistry and Pharmacology
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  • 6
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Chem. Sci. , 2019, 10 ,145-152 DOI : 10.1039/C8SC03694B, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Yingying Huo, Junfeng Miao, Junru Fang, Hu Shi, Juanjuan Wang, Wei Guo Fluorescent NO probes reported herein display high sensitivity for NO by responding to both N 2 O 3 and ONOO − and robust abilities for evaluating the repolarization of tumor-associated macrophages (TAMs). The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 2041-6520
    Electronic ISSN: 2041-6539
    Topics: Chemistry and Pharmacology
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  • 7
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: CrystEngComm , 2019, Advance Article DOI : 10.1039/C8CE01949E, Paper Yunzhong Zhu, Shaopeng Lin, Zhihua Liu, Wenjia Wang, Decai Ma, Biao Wang Growth interface electromotive force (GEMF) visualizes the real-time states of crystal growth rate, supercooling degree and rotation temperature fluctuations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Electronic ISSN: 1466-8033
    Topics: Geosciences , Physics
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  • 8
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: CrystEngComm , 2019, Advance Article DOI : 10.1039/C8CE01876F, Paper Elham Bagherzadeh, Seyed Mojtaba Zebarjad, Hamid Reza Madaah Hosseini, Pierre Chagnon Investigating the kinetics of crystallization, growth behavior and morphological changes through statistical studies of Fe-MIL-88A suggested an autocatalytic nucleation mechanism. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Electronic ISSN: 1466-8033
    Topics: Geosciences , Physics
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  • 9
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: CrystEngComm , 2018, Accepted Manuscript DOI : 10.1039/C8CE02086H, Communication Arpita Paikar, Debasish Podder, Srayoshi Roy Chowdhury, Supriya Sasmal, Debasish Haldar Ethyl 3-(3-bromo-4-methoxy-phenyl)-2-cyano-acrylate crystals exhibited very superior plasticity, shape persistent, self-standing properties compared to its non bromo-analogue. The crystal plasticity controlled by bromine-bromine interaction that has been found to play a... The content of this RSS Feed (c) The Royal Society of Chemistry
    Electronic ISSN: 1466-8033
    Topics: Geosciences , Physics
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  • 10
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: CrystEngComm , 2019, Advance Article DOI : 10.1039/C8CE01892H, Communication Yanli Fu, Liqiong Wu, Shengang Xu, Shaokui Cao, Xinheng Li LiNi 0.5 Mn 1.5 O 4 microcubes grown from nanowires delivered an initial discharge capacity of 123 mAh g −1 at 1C and maintained 95% of the capacity after 50 cycles due to interfacial effect. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Electronic ISSN: 1466-8033
    Topics: Geosciences , Physics
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  • 11
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: CrystEngComm , 2019, Advance Article DOI : 10.1039/C8CE01658E, Paper Jun Kobayashi, Toshiyuki Misawa, Chihiro Umeda, Toru Isono, Seiji Ono, Haruo Naruke, Yosuke Okamura, Shinichi Koguchi, Masashi Higuchi, Yu Nagase, Takeru Ito The first syntheses of polyoxomolybdate hybrid crystals were achieved by using polymerizable ionic-liquid. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Electronic ISSN: 1466-8033
    Topics: Geosciences , Physics
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  • 12
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Dalton Trans. , 2019, Advance Article DOI : 10.1039/C8DT04069A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Lara M. Groves, Catrin F. Williams, Anthony J. Hayes, Benjamin D. Ward, Marc D. Isaacs, Nadine O. Symonds, David Lloyd, Peter N. Horton, Simon J. Coles, Simon J. A. Pope A series of fluorescent gold( I )–NHC complexes have been developed and investigated as cell imaging agents. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1477-9226
    Topics: Chemistry and Pharmacology
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  • 13
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Dalton Trans. , 2019, Advance Article DOI : 10.1039/C8DT04019B, Frontier Ian James McPherson, Tim Sudmeier, Joshua Fellowes, Shik Chi Edman Tsang Direct electrochemical synthesis of ammonia is proposed as a means of reducing the carbon footprint of the fertiliser industry, as well as providing new opportunities for carbon-free liquid energy storage. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1477-9226
    Topics: Chemistry and Pharmacology
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  • 14
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Dalton Trans. , 2019, Advance Article DOI : 10.1039/C8DT03576H, Paper Alexander Friedrich, Jürgen Pahl, Holger Elsen, Sjoerd Harder Cationic β-diketiminate Mg complexes with the bulky t Bu BDI ligand and the weakly coordinating anion B(C 6 F 5 ) 4 − have been prepared by the reaction of ( t Bu BDI)Mg n Bu with [Ph 3 C] + [B(C 6 F 5 ) 4 ] − ; t Bu BDI = CH[C( t Bu)N-Dipp] 2 and Dipp = 2,6-diisopropylphenyl. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1477-9226
    Topics: Chemistry and Pharmacology
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  • 15
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Dalton Trans. , 2019, Advance Article DOI : 10.1039/C8DT04347G, Paper Po-Jung Huang, Yoshiki Natori, Yasutaka Kitagawa, Yoshihiro Sekine, Wataru Kosaka, Hitoshi Miyasaka The HOMO/LUMO energy levels of paddlewheel [Cr 2 (RCO 2 ) 4 (THF) 2 ] complexes are effectively tuned by the substitution of the equatorial RCO 2 − ligands. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1477-9226
    Topics: Chemistry and Pharmacology
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  • 16
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Dalton Trans. , 2019, Advance Article DOI : 10.1039/C8DT04258F, Frontier Ralf Haiges The recent acomplished syntheses of novel metal oxopolyazides VO(N 3 ) 3 , NbO(N 3 ) 3 , NbO(N 3 ) 3 ·2CH 3 CN, MoO(N 3 ) 3 , MoO(N 3 ) 3 ·2CH 3 CN, WO(N 3 ) 4 , WO(N 3 ) 4 ·CH 3 CN, MoO 2 (N 3 ) 2 , MoO 2 (N 3 ) 2 ·2CH 3 CN, WO 2 (N 3 ) 2 , WO 2 (N 3 ) 2 ·2CH 3 CN and UO 2 (N 3 ) 2 ·CH 3 CN by the author is reviewed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1477-9226
    Topics: Chemistry and Pharmacology
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  • 17
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Dalton Trans. , 2019, Advance Article DOI : 10.1039/C8DT04495C, Communication Caixia Li, Ran Tao, Zhanbin Jin, Fengyan Li, Wencheng Fang, Lin Xu A water-soluble titanium( IV )-oxo-cluster (K 6 [K 3 Ti 3 O 4 (O 2 ) 3 (C 7 H 3 O 4 N) 3 (OH 2 ) 2 ]Cl·4H 2 O) 1 has been successfully synthesized and it shows a 2D layered structure through the connection of potassium ions. Its application in photoelectrooxidation activity for DA was also investigated primarily. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1477-9226
    Topics: Chemistry and Pharmacology
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  • 18
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Dalton Trans. , 2019, Advance Article DOI : 10.1039/C8DT04225J, Paper Paweł Mazierski, Jakub Sowik, Magdalena Miodyńska, Grzegorz Trykowski, Alicja Mikołajczyk, Tomasz Klimczuk, Wojciech Lisowski, Joanna Nadolna, Adriana Zaleska-Medynska Novel visible light responsive materials for water splitting are essential for the efficient conversion of solar energy into hydrogen bond energy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1477-9226
    Topics: Chemistry and Pharmacology
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  • 19
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Dalton Trans. , 2018, Accepted Manuscript DOI : 10.1039/C8DT03406K, Perspective Kenton Whitmire, Desmond E Schipper In this perspective, the development of single-source precursors and their relative advantages over multiple source approaches for the synthesis of metal pnictide solid state materials is explored. Particular efforts in... The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1477-9226
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  • 20
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Environ. Sci.: Water Res. Technol. , 2019, Advance Article DOI : 10.1039/C8EW00642C, Paper Kuo Gao, Tian Li, Junxia Liu, Bingzhi Dong, Huaqiang Chu Ultrafiltration membrane fouling caused by mixtures of micromolecules (humic acid, HA) and macromolecules (sodium alginate, SA) was studied in a comprehensive manner. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 2053-1400
    Electronic ISSN: 2053-1419
    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 21
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Environ. Sci.: Water Res. Technol. , 2019, Advance Article DOI : 10.1039/C8EW00541A, Communication Jia Niu, Ikuro Kasuga, Futoshi Kurisu, Hiroaki Furumai By applying time-course DNA-SIP, the substrate niche separation of AOA and AOB was revealed. AOA had higher autotrophic growth activity for a low concentration of ammonium, while AOB directly incorporated and hydrolyzed urea. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 2053-1400
    Electronic ISSN: 2053-1419
    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 22
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Lab Chip , 2019, Advance Article DOI : 10.1039/C8LC01077C, Paper Tally Rosenfeld, Moran Bercovici The paper-based electroosmotic (EO)-pump is used to accelerate/decelerate the capillary-driven velocity, as well as act as a reversible and tunable valve. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1473-0197
    Electronic ISSN: 1473-0189
    Topics: Chemistry and Pharmacology
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  • 23
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Dalton Trans. , 2019, Advance Article DOI : 10.1039/C8DT04408B, Paper Zhenyu Xin, Lei Lu, Bing Wang, Xiaohui Wang, Kai Zhu, Zhe Xu, Zhentao Yu, Shicheng Yan, Zhigang Zou Improvement of light harvesting and reaction kinetics is of great importance for achieving efficient solar-driven CO 2 reduction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1477-9226
    Topics: Chemistry and Pharmacology
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  • 24
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Lab Chip , 2019, Advance Article DOI : 10.1039/C8LC01117F, Paper Yaqi Zhang, Citsabehsan Devendran, Christopher Lupton, Alex de Marco, Adrian Neild We present a dextrous microfluidic device which features a reaction chamber with volume flexibility and acoustic mixing. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1473-0197
    Electronic ISSN: 1473-0189
    Topics: Chemistry and Pharmacology
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  • 25
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Lab Chip , 2019, Advance Article DOI : 10.1039/C8LC00922H, Paper Navjot Kaur Gill, Chau Ly, Kendra D. Nyberg, Linus Lee, Dongping Qi, Bobby Tofig, Mariana Reis-Sobreiro, Oliver Dorigo, JianYu Rao, Ruprecht Wiedemeyer, Beth Karlan, Kate Lawrenson, Michael R. Freeman, Robert Damoiseaux, Amy C. Rowat We demonstrate a scalable, high throughput method to screen cells based on their ability to deform through micron-scale gaps. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1473-0197
    Electronic ISSN: 1473-0189
    Topics: Chemistry and Pharmacology
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  • 26
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-20
    Description: Breaking the speed limit with multimode fast scanning of DNA by Endonuclease V Breaking the speed limit with multimode fast scanning of DNA by Endonuclease V, Published online: 19 December 2018; doi:10.1038/s41467-018-07797-4 How DNA repair proteins locate their target sites on DNA is still a matter of debate. Here the authors characterize by single-molecule fluorescence imaging the modes of scanning adopted by bacterial endonuclease V as it moves along linear DNA tracks.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 27
    Publication Date: 2018-12-20
    Description: Integrin CD11b activation drives anti-tumor innate immunity Integrin CD11b activation drives anti-tumor innate immunity, Published online: 19 December 2018; doi:10.1038/s41467-018-07387-4 Recruitment of myeloid cells can be regulated by integrin CD11b. Here the authors show that in the tumor microenvironment, CD11b is not essential for recruitment of myeloid cells but rather induces macrophage anti-tumorigenic polarization via stimulating let7a and NFκB signaling and that pharmacological activation of CD11b enhances survival in mouse models of cancer.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 28
    Publication Date: 2018-12-20
    Description: SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4, Published online: 19 December 2018; doi:10.1038/s41467-018-07620-0 SRPK1, a kinase involved in splicing regulation, is a potential therapeutic target for AML patients. Here, the authors show that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects specifically against MLL-rearranged AML cells.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 29
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-20
    Description: Ultrastrong nanocrystalline steel with exceptional thermal stability and radiation tolerance Ultrastrong nanocrystalline steel with exceptional thermal stability and radiation tolerance, Published online: 19 December 2018; doi:10.1038/s41467-018-07712-x Weaker ferritic/matensitic steels rather than stronger austenitic steels are usually candidates for nuclear reactors since they do not easily swell under irradiation. Here, the authors make an ultrastrong lanthanum-doped nanocrystalline austenitic steel that is thermally stable and radiation-tolerant.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 30
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-20
    Description: RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes, Published online: 19 December 2018; doi:10.1038/s41467-018-07783-w Pre-ribosomes undergo numerous structural rearrangements during their assembly. Here the authors identify the binding sites of three essential RNA helicases on pre-ribosomal particles, enabling them to provide insights into the structural and compositional changes that occur during biogenesis of the large ribosomal subunit.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 31
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Photochem. Photobiol. Sci. , 2019, Advance Article DOI : 10.1039/C8PP00462E, Paper Dongdong Zheng, Mina Raeisolsadati Oskouei, Hans J. Sanders, Junhong Qian, René M. Williams, Albert M. Brouwer A fluorophore-tagged organocatalyst undergoes electron transfer in polar solvents allowing to sense the presence of its free quinuclidine catalytic site. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1474-905X
    Electronic ISSN: 1474-9092
    Topics: Chemistry and Pharmacology
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  • 32
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    American Physical Society (APS)
    Publication Date: 2018-12-20
    Description: Author(s): Markus P. Müller Recent research has hinted at the need for a family of thermodynamic second laws at the quantum scale, but a new analysis shows this isn’t always the case. [Phys. Rev. X 8, 041051] Published Wed Dec 19, 2018
    Electronic ISSN: 2160-3308
    Topics: Physics
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  • 33
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    American Physical Society (APS)
    In: Physics
    Publication Date: 2018-12-20
    Description: Author(s): Lindsay LeBlanc Experimentalists working with cold atoms are closing in on the famous Stoner model of ferromagnetism. [Physics 11, 131] Published Wed Dec 19, 2018
    Electronic ISSN: 1539-0748
    Topics: Physics
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  • 34
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    American Physical Society (APS)
    In: Physics
    Publication Date: 2018-12-20
    Description: At the American Geophysical Union Fall Meeting, researchers described progress on balloon-borne infrasound detectors that observe seismic events on Earth and could eventually go on Venus. [Physics 11, 132] Published Wed Dec 19, 2018
    Electronic ISSN: 1539-0748
    Topics: Physics
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  • 35
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-20
    Description: Emerging negative impact of warming on summer carbon uptake in northern ecosystems Emerging negative impact of warming on summer carbon uptake in northern ecosystems, Published online: 19 December 2018; doi:10.1038/s41467-018-07813-7 The impacts of climate change on summer carbon cycling in the northern hemisphere remain poorly resolved. Here the authors use atmospheric CO2 records from Point Barrow (Alaska) to show that summer CO2 drawdown is significantly negatively correlated with terrestrial temperature north of 50°N between 1979–2012.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 36
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-20
    Description: Closure of the Bering Strait caused Mid-Pleistocene Transition cooling Closure of the Bering Strait caused Mid-Pleistocene Transition cooling, Published online: 19 December 2018; doi:10.1038/s41467-018-07828-0 The causes of Mid-Pleistocene Transition global cooling 1 million years ago are still unknown. Here, the authors find the subarctic North Pacific became stratified during these glaciations due to closure of the Bering Strait, which would have removed CO2 from the atmosphere and caused global cooling.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 37
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Dan Xu, Minghui Yao, Yaqing Wang, Ling Yuan, Joerg D. Hoeck, Jingwen Yu, Liang Liu, Yvonne Y. C. Yeap, Weiya Zhang, Feng Zhang, Yinghang Feng, Tiantian Ma, Yujie Wang, Dominic C. H. Ng, Xiaoyin Niu, Bing Su, Axel Behrens, Zhiheng Xu Mutations of WD repeat domain 62 ( WDR62 ) lead to autosomal recessive primary microcephaly (MCPH), and down-regulation of WDR62 expression causes the loss of neural progenitor cells (NPCs). However, how WDR62 is regulated and hence controls neurogenesis and brain size remains elusive. Here, we demonstrate that mitogen-activated protein kinase kinase kinase 3 (MEKK3) forms a complex with WDR62 to promote c-Jun N-terminal kinase (JNK) signaling synergistically in the control of neurogenesis. The deletion of Mekk3 , Wdr62 , or Jnk1 resulted in phenocopied defects, including premature NPC differentiation. We further showed that WDR62 protein is positively regulated by MEKK3 and JNK1 in the developing brain and that the defects of wdr62 deficiency can be rescued by the transgenic expression of JNK1 . Meanwhile, WDR62 is also negatively regulated by T1053 phosphorylation, leading to the recruitment of F-box and WD repeat domain-containing protein 7 (FBW7) and proteasomal degradation. Our findings demonstrate that the coordinated reciprocal and bidirectional regulation among MEKK3, FBW7, WDR62, and JNK1, is required for fine-tuned JNK signaling for the control of balanced NPC self-renewal and differentiation during cortical development.
    Print ISSN: 1544-9173
    Electronic ISSN: 1545-7885
    Topics: Biology
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Brielin C. Brown, Nicolas L. Bray, Lior Pachter Population structure in genotype data has been extensively studied, and is revealed by looking at the principal components of the genotype matrix. However, no similar analysis of population structure in gene expression data has been conducted, in part because a naïve principal components analysis of the gene expression matrix does not cluster by population. We identify a linear projection that reveals population structure in gene expression data. Our approach relies on the coupling of the principal components of genotype to the principal components of gene expression via canonical correlation analysis. Our method is able to determine the significance of the variance in the canonical correlation projection explained by each gene. We identify 3,571 significant genes, only 837 of which had been previously reported to have an associated eQTL in the GEUVADIS results. We show that our projections are not primarily driven by differences in allele frequency at known cis-eQTLs and that similar projections can be recovered using only several hundred randomly selected genes and SNPs. Finally, we present preliminary work on the consequences for eQTL analysis. We observe that using our projection co-ordinates as covariates results in the discovery of slightly fewer genes with eQTLs, but that these genes replicate in GTEx matched tissue at a slightly higher rate.
    Print ISSN: 1553-7390
    Electronic ISSN: 1553-7404
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Kun Zhu, Yi Tang, Xuan Xu, Hien Dang, Liu-Ya Tang, Xiang Wang, Xin Wei Wang, Ying E. Zhang Nonalcoholic fatty liver disease (NAFLD) is characterized by abnormal accumulation of triglycerides (TG) in the liver and other metabolic syndrome symptoms, but its molecular genetic causes are not completely understood. Here, we show that mice deficient for ubiquitin ligase (E3) Smad ubiquitin regulatory factor 1 (Smurf1) spontaneously develop hepatic steatosis as they age and exhibit the exacerbated phenotype under a high-fat diet (HFD). Our data indicate that loss of Smurf1 up-regulates the expression of peroxisome proliferator-activated receptor γ (PPARγ) and its target genes involved in lipid synthesis and fatty acid uptake. We further show that PPARγ is a direct substrate of Smurf1-mediated non-proteolytic lysine 63 (K63)-linked ubiquitin modification that suppresses its transcriptional activity, and treatment of Smurf1-deficient mice with a PPARγ antagonist, GW9662, completely reversed the lipid accumulation in the liver. Finally, we demonstrate an inverse correlation of low SMURF1 expression to high body mass index (BMI) values in human patients, thus revealing a new role of SMURF1 in NAFLD pathogenesis.
    Print ISSN: 1544-9173
    Electronic ISSN: 1545-7885
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  • 40
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Felix Day, Tugce Karaderi, Michelle R. Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Magi, Richa Saxena, Triin Laisk, Margrit Urbanek, M. Geoffrey Hayes, Gudmar Thorleifsson, Juan Fernandez-Tajes, Anubha Mahajan, Benjamin H. Mullin, Bronwyn G. A. Stuckey, Timothy D. Spector, Scott G. Wilson, Mark O. Goodarzi, Lea Davis, Barbara Obermayer-Pietsch, André G. Uitterlinden, Verneri Anttila, Benjamin M. Neale, Marjo-Riitta Jarvelin, Bart Fauser, Irina Kowalska, Jenny A. Visser, Marianne Andersen, Ken Ong, Elisabet Stener-Victorin, David Ehrmann, Richard S. Legro, Andres Salumets, Mark I. McCarthy, Laure Morin-Papunen, Unnur Thorsteinsdottir, Kari Stefansson, the 23andMe Research Team , Unnur Styrkarsdottir, John R. B. Perry, Andrea Dunaif, Joop Laven, Steve Franks, Cecilia M. Lindgren, Corrine K. Welt Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have metabolic disturbances including insulin resistance and dysregulation of glucose homeostasis. PCOS is diagnosed with two different sets of diagnostic criteria, resulting in a phenotypic spectrum of PCOS cases. The genetic similarities between cases diagnosed based on the two criteria have been largely unknown. Previous studies in Chinese and European subjects have identified 16 loci associated with risk of PCOS. We report a fixed-effect, inverse-weighted-variance meta-analysis from 10,074 PCOS cases and 103,164 controls of European ancestry and characterisation of PCOS related traits. We identified 3 novel loci (near PLGRKT , ZBTB16 and MAPRE1 ), and provide replication of 11 previously reported loci. Only one locus differed significantly in its association by diagnostic criteria; otherwise the genetic architecture was similar between PCOS diagnosed by self-report and PCOS diagnosed by NIH or non-NIH Rotterdam criteria across common variants at 13 loci. Identified variants were associated with hyperandrogenism, gonadotropin regulation and testosterone levels in affected women. Linkage disequilibrium score regression analysis revealed genetic correlations with obesity, fasting insulin, type 2 diabetes, lipid levels and coronary artery disease, indicating shared genetic architecture between metabolic traits and PCOS. Mendelian randomization analyses suggested variants associated with body mass index, fasting insulin, menopause timing, depression and male-pattern balding play a causal role in PCOS. The data thus demonstrate 3 novel loci associated with PCOS and similar genetic architecture for all diagnostic criteria. The data also provide the first genetic evidence for a male phenotype for PCOS and a causal link to depression, a previously hypothesized comorbid disease. Thus, the genetics provide a comprehensive view of PCOS that encompasses multiple diagnostic criteria, gender, reproductive potential and mental health.
    Print ISSN: 1553-7390
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    American Physical Society (APS)
    In: Physics
    Publication Date: 2018-12-20
    Description: An ultrafast photoemission experiment characterizes the processes by which photoexcited electrons in graphite return to thermal equilibrium. [Physics] Published Wed Dec 19, 2018
    Electronic ISSN: 1539-0748
    Topics: Physics
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  • 42
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-20
    Description: Concurrent influence of top-down and bottom-up inputs on correlated activity of Macaque extrastriate neurons Concurrent influence of top-down and bottom-up inputs on correlated activity of Macaque extrastriate neurons, Published online: 19 December 2018; doi:10.1038/s41467-018-07816-4 Changes in correlated activity of neurons are believed to influence their information coding capacity. Here, the authors show how top-down and bottom-up inputs and their interaction differentially alter the correlated activity of neurons in extrastriate cortex
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 43
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Stanislav Nagy, Gianna W. Maurer, Julie L. Hentze, Morten Rose, Thomas M. Werge, Kim Rewitz The human 1q21.1 deletion of ten genes is associated with increased risk of schizophrenia. This deletion involves the β-subunit of the AMP-activated protein kinase (AMPK) complex, a key energy sensor in the cell. Although neurons have a high demand for energy and low capacity to store nutrients, the role of AMPK in neuronal physiology is poorly defined. Here we show that AMPK is important in the nervous system for maintaining neuronal integrity and for stress survival and longevity in Drosophila . To understand the impact of this signaling system on behavior and its potential contribution to the 1q21.1 deletion syndrome, we focused on sleep, an important role of which is proposed to be the reestablishment of neuronal energy levels that are diminished during energy-demanding wakefulness. Sleep disturbances are one of the most common problems affecting individuals with psychiatric disorders. We show that AMPK is required for maintenance of proper sleep architecture and for sleep recovery following sleep deprivation. Neuronal AMPKβ loss specifically leads to sleep fragmentation and causes dysregulation of genes believed to play a role in sleep homeostasis. Our data also suggest that AMPKβ loss may contribute to the increased risk of developing mental disorders and sleep disturbances associated with the human 1q21.1 deletion.
    Print ISSN: 1553-7390
    Electronic ISSN: 1553-7404
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  • 44
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Laura A. Steenhuis, Maaike H. Nauta, Claudi L. H. Bockting, Gerdina H. M. Pijnenborg
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 45
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by The PLOS ONE Staff
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 46
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Shin-Hye Kim, Ji-won On, Heesoo Pyo, Kyung Soo Ko, Jong Chul Won, Jiyeon Yang, Mi Jung Park
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 47
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Marcin Studnicki, Grażyna Woźniak, Dariusz Stępkowski
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 48
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Rene Westerholt, Enrico Steiger, Bernd Resch, Alexander Zipf
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 49
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Limin Li, Yen Yen Woo, Jessie Anne de Bruyne, Anna Marie Nathan, Sze Ying Kee, Yoke Fun Chan, Chun Wei Chiam, Kah Peng Eg, Surendran Thavagnanam, I-Ching Sam
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 50
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Krishna Das, David Eisel, Clarissa Lenkl, Ashish Goyal, Sven Diederichs, Elke Dickes, Wolfram Osen, Stefan B. Eichmüller
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 51
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Mirian Sánchez-Morán, Juan Andrés Hernández, Jon Andoni Duñabeitia, Adelina Estévez, Laura Bárcena, Aintzane González-Lahera, María Teresa Bajo, Luis J. Fuentes, Ana M. Aransay, Manuel Carreiras
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 52
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by The PLOS ONE Staff
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 53
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Francisco J. Santiago-Avila, Ari M. Cornman, Adrian Treves
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 54
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Haesuk Park, Donghak Jeong, Pauline Nguyen, Linda Henry, Joseph Hoang, Yoona Kim, Edward Sheen, Mindie H. Nguyen
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 55
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Aurora Sabrià, Rosa M. Pintó, Albert Bosch, Josep Quer, Damir Garcia-Cehic, Josep Gregori, Angela Dominguez, Mónica Carol, Maria-Rosa Sala-Farré, Susana Guix, the Working Group for the Study of Outbreaks of Acute Gastroenteritis in Catalonia
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 56
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Osei Owusu-Afriyie, W. K. B. A. Owiredu, Kwabena Owusu-Danquah, Christine Komarck, Susan K. Foltin, Rita Larsen-Reindorf, Emmanuel Acheampong, Solomon E. Quayson, Mark E. Prince, Jonathan B. McHugh, Peter Donkor, Sofia D. Merajver, J. Chad Brenner
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 57
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Tak Kyu Oh, In Sun Park, Eunjeong Ji, Hyo-Seok Na Whether preoperative spirometry in non-thoracic surgery can predict postoperative pulmonary complications (PPCs) is controversial. We investigated whether preoperative spirometry results can predict the occurrence of PPCs in patients who had undergone laparoscopic abdominal surgery. This retrospective observational study analyzed the records of patients who underwent inpatient laparoscopic gastric or colorectal cancer surgery at Seoul National University Bundang Hospital between January 2010 and June 2017. Preoperative spirometry was performed for patients at a high risk of PPCs, such as elderly patients (age 〉60 years), patients aged
    Electronic ISSN: 1932-6203
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  • 58
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by James Tosin Akinlua, Richard Meakin, Ibrahim Bashir, Nick Freemantle Objective The main objective of the study was to elicit beliefs about hypertension among Nigerian Primary Health Care clients and workers. Background In many regions of Nigeria, the primary health care facility is usually the only source of formal health care available. Since hypertension is a chronic condition that requires lifelong life style modification and drug treatment, it is important to understand the context and background to the condition through the beliefs and perceptions among both lay persons and health care providers who manage the condition. Setting Rural and urban primary health care facilities in the Federal Capital Territory Nigeria. Participants A total of Eighty-one (81) primary health care clients and workers participated in the study. Methods and outcome measure A qualitative research using interviews, focus group discussions and reflective work as sources of data collection. The outcome measures were emerging themes from thematic framework analysis. Results There were four themes that summarize beliefs of both PHC workers and clients namely: (1) Meaning of hypertension (2) causes of hypertension, (3) Consequences of hypertension (4) Perceptions of treatment, one additional distinct theme was elicited among PHC workers “contextual explanation”. However, under each of the shared four themes, there were both similarities and differences in beliefs expressed between PHC workers and clients. Conclusions This study highlights important similarities and differences in beliefs about hypertension among primary health care clients and primary health care workers that have significant implications for management of hypertension in primary care settings in Nigeria.
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 59
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Anat Gesser-Edelsburg, Alon Diamant, Rana Hijazi, Gustavo S. Mesch Background During epidemic crises, some of the information the public receives on social media is misinformation. Health organizations are required to respond and correct the information to gain the public’s trust and influence it to follow the recommended instructions. Objectives (1) To examine ways for health organizations to correct misinformation concerning the measles vaccination on social networks for two groups: pro-vaccination and hesitant; (2) To examine the types of reactions of two subgroups (pro-vaccination, hesitant) to misinformation correction; and (3) To examine the effect of misinformation correction on these two subgroups regarding reliability, satisfaction, self-efficacy and intentions. Methods A controlled experiment with participants divided randomly into two conditions. In both experiment conditions a dilemma was presented as to sending a child to kindergarten, followed by an identical Facebook post voicing the children mothers’ concerns. In the third stage the correction by the health organization is presented differently in two conditions: Condition 1 –common information correction, and Condition 2 –recommended (theory-based) information correction, mainly communicating information transparently and addressing the public’s concerns. The study included (n = 243) graduate students from the Faculty of Social Welfare and Health Sciences at Haifa University. Results A statistically significant difference was found in the reliability level attributed to information correction by the Health Ministry between the Control condition and Experimental condition (sig
    Electronic ISSN: 1932-6203
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  • 60
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Helena Wallin, Anna M. Asp, Carin Wallquist, Eva Jansson, Kenneth Caidahl, Britta Hylander Rössner, Stefan H. Jacobson, Anette Rickenlund, Maria J. Eriksson Background The cause of reduced exercise capacity (ExCap) in chronic kidney disease (CKD) is multifactorial. The aim of this study was to investigate determinants of aerobic ExCap in patients with mild to severe CKD not undergoing dialysis. Methods We included 52 individuals with CKD stage 2–3, 47 with stage 4–5, and 54 healthy controls. Peak workload and peak heart rate (HR) were assessed by a maximal cycle exercise test. Cardiac function including stroke volume (SV) and vascular stiffness were evaluated by ultrasound at rest. Handgrip strength, body composition, haemoglobin level and self-reported physical activity were assessed. Results Peak workload (221±60, 185±59, 150±54 W for controls, CKD 2–3 and CKD 4–5 respectively), peak HR (177±11, 161±24, 144±31 beats/min) and haemoglobin level (14.2±1.2, 13.5±1.4, 12.2±1.3 g/dL) were all three significantly lower in CKD 2–3 than in controls, (p = 0.001, 0.001 and 0.03 respectively) and were even lower in stages 4–5 CKD than in CKD 2–3 (p = 0.01, 0.001 and
    Electronic ISSN: 1932-6203
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  • 61
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Christian Thue Bjørndal, Live S. Luteberget, Kevin Till, Simen Holm Many elite sport organisations have introduced structured talent identification and development (TID) initiatives in youth sports to better facilitate elite sport performance. However, selection mechanisms for TID programmes (e.g., junior international team) are biased towards relatively older athletes and limited studies exist with Scandinavian contexts. Therefore, the aim of this study was to explore the relative age effect (RAE) in youth, junior and senior male and female international team selections among Norwegian handball players (n = 657). A Chi-square goodness-of-fit test assessed whether a skewed birthdate distribution occurred at the youth, junior and senior international team levels and odds-ratios were calculated for RAE distribution. Moreover, a Kruskal-Wallis test was used to assess differences between the number of international youth, junior and senior level appearances by birth quartiles. Significant uneven birth date distributions were shown for youth (χ 2 (7) = female 40.383 and male 105.716, p
    Electronic ISSN: 1932-6203
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  • 62
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-20
    Description: by Marieke de Visser, Cornelia Fluit, Janke Cohen-Schotanus, Roland Laan Background Medical schools aim to contribute to a pool of doctors who are ready for a future practice that will be ever-changing requiring collaboration skills and lifelong learning. They adapt their curricula and selection procedures to fulfil this responsibility. This study aims to determine whether two different selection procedures in one medical school, both matching the key characteristics of the subsequent curricula (one traditional, knowledge-based, and one recently designed for self directed learning and focusing on practice), select students with different personality traits as a side-effect. This perspective was chosen as personality has been related to the CanMeds competencies, innovation capacities, medical school performance and medical professional success. Methods A total of 621 students admitted through the new or the traditional selection procedure were invited to complete a Big Five Inventory questionnaire at the start of their Bachelor’s programme. Using ANCOVA, we compared Big Five traits of students admitted through the new selection procedure (n = 196) and the traditional selection procedure (n = 425). Results The group of students admitted through the procedure matching the newly designed curriculum had a lower mean score on neuroticism (p 〈 .01) and higher mean scores on conscientiousness, extraversion, agreeableness and openness (p 〈 .001) than the other group. Conclusions The findings of the current study indicate that the medical school population is influenced in terms of personality traits as a side-effect of a changing selection procedure. We recommend studying this mechanism and its implications further and using it more consciously in selection procedure design.
    Electronic ISSN: 1932-6203
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  • 63
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2018-12-20
    Description: Dense suspensions of swimming bacteria are living fluids, an archetype of active matter. For example, Bacillus subtilis confined within a disc-shaped region forms a persistent stable vortex that counterrotates at the periphery. Here, we examined Escherichia coli under similar confinement and found that these bacteria, instead, form microspin cycles: a single vortex that periodically reverses direction on time scales of seconds. Using experimental perturbations of the confinement geometry, medium viscosity, bacterial length, density, and chemotaxis pathway, we show that morphological alterations of the bacteria transition a stable vortex into a periodically reversing one. We develop a mathematical model based on single-cell biophysics that quantitatively recreates the dynamics of these vortices and predicts that density gradients power the reversals. Our results define how microbial physics drives the active behavior of dense bacterial suspensions and may allow one to engineer novel micromixers for biomedical and other microfluidic applications.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 64
    Publication Date: 2018-12-20
    Description: After European colonization, the ancestral remains of Indigenous people were often collected for scientific research or display in museum collections. For many decades, Indigenous people, including Native Americans and Aboriginal Australians, have fought for their return. However, many of these remains have no recorded provenance, making their repatriation very difficult or impossible. To determine whether DNA-based methods could resolve this important problem, we sequenced 10 nuclear genomes and 27 mitogenomes from ancient pre-European Aboriginal Australians (up to 1540 years before the present) of known provenance and compared them to 100 high-coverage contemporary Aboriginal Australian genomes, also of known provenance. We report substantial ancient population structure showing strong genetic affinities between ancient and contemporary Aboriginal Australian individuals from the same geographic location. Our findings demonstrate the feasibility of successfully identifying the origins of unprovenanced ancestral remains using genomic methods.
    Electronic ISSN: 2375-2548
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  • 65
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2018-12-20
    Description: Characterization of the tumor microenvironment, including extracellular vesicles (EVs), is important for understanding cancer progression. EV studies have traditionally been performed on dissociated cells, lacking spatial information. Since the distribution of EVs in the tumor microenvironment is associated with cellular function, there is a strong need for visualizing EVs in freshly resected tissues. We intraoperatively imaged untreated human breast tissues using a custom nonlinear imaging system. Label-free optical contrasts of the tissue, correlated with histological findings, enabled point-of-procedure characterization of the tumor microenvironment. EV densities from 29 patients with breast cancer were found to increase with higher histologic grade and shorter tumor-to-margin distance and were significantly higher than those from 7 cancer-free patients undergoing breast reduction surgery. Acquisition and interpretation of these intraoperative images not only provide real-time visualization of the tumor microenvironment but also offer the potential to use EVs as a label-free biomarker for cancer diagnosis and prognosis.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 66
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2018-12-20
    Description: Intracranial hemorrhage can be a devastating complication associated with needle biopsies of the brain. Hemorrhage can occur to vessels located adjacent to the biopsy needle as tissue is aspirated into the needle and removed. No intraoperative technology exists to reliably identify blood vessels that are at risk of damage. To address this problem, we developed an "imaging needle" that can visualize nearby blood vessels in real time. The imaging needle contains a miniaturized optical coherence tomography probe that allows differentiation of blood flow and tissue. In 11 patients, we were able to intraoperatively detect blood vessels (diameter, 〉500 μm) with a sensitivity of 91.2% and a specificity of 97.7%. This is the first reported use of an optical coherence tomography needle probe in human brain in vivo. These results suggest that imaging needles may serve as a valuable tool in a range of neurosurgical needle interventions.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 67
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-20
    Description: Author Correction: Optimization of Photosensitized Tryptophan Oxidation in the Presence of Dimegin-Polyvinylpyrrolidone-Chitosan Systems Author Correction: Optimization of Photosensitized Tryptophan Oxidation in the Presence of Dimegin-Polyvinylpyrrolidone-Chitosan Systems, Published online: 20 December 2018; doi:10.1038/s41598-018-37181-7 Author Correction: Optimization of Photosensitized Tryptophan Oxidation in the Presence of Dimegin-Polyvinylpyrrolidone-Chitosan Systems
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 68
    Publication Date: 2018-12-20
    Description: Streptococcus mitis Expressing Pneumococcal Serotype 1 Capsule 〈i〉Streptococcus mitis〈/i〉 Expressing Pneumococcal Serotype 1 Capsule, Published online: 19 December 2018; doi:10.1038/s41598-018-35921-3 Streptococcus mitis Expressing Pneumococcal Serotype 1 Capsule
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-20
    Description: Visual capture of gait during redirected walking Visual capture of gait during redirected walking, Published online: 19 December 2018; doi:10.1038/s41598-018-36035-6 Visual capture of gait during redirected walking
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-20
    Description: Impact of combined ischemic preconditioning and remote ischemic perconditioning on ischemia-reperfusion injury after liver transplantation Impact of combined ischemic preconditioning and remote ischemic perconditioning on ischemia-reperfusion injury after liver transplantation, Published online: 19 December 2018; doi:10.1038/s41598-018-36365-5 Impact of combined ischemic preconditioning and remote ischemic perconditioning on ischemia-reperfusion injury after liver transplantation
    Electronic ISSN: 2045-2322
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-20
    Description: Scanning electron microscopy examination of needle tips after different procedures of deep dry needling in humans Scanning electron microscopy examination of needle tips after different procedures of deep dry needling in humans, Published online: 19 December 2018; doi:10.1038/s41598-018-36417-w Scanning electron microscopy examination of needle tips after different procedures of deep dry needling in humans
    Electronic ISSN: 2045-2322
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-20
    Description: Human ex vivo 3D bone model recapitulates osteocyte response to metastatic prostate cancer Human ex vivo 3D bone model recapitulates osteocyte response to metastatic prostate cancer, Published online: 19 December 2018; doi:10.1038/s41598-018-36424-x Human ex vivo 3D bone model recapitulates osteocyte response to metastatic prostate cancer
    Electronic ISSN: 2045-2322
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-20
    Description: Structure and magnetism of ultrathin nickel-iron oxides grown on Ru(0001) by high-temperature oxygen-assisted molecular beam epitaxy Structure and magnetism of ultrathin nickel-iron oxides grown on Ru(0001) by high-temperature oxygen-assisted molecular beam epitaxy, Published online: 19 December 2018; doi:10.1038/s41598-018-36356-6 Structure and magnetism of ultrathin nickel-iron oxides grown on Ru(0001) by high-temperature oxygen-assisted molecular beam epitaxy
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 74
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-20
    Description: Exploring the rumen fluid metabolome using liquid chromatography-high-resolution mass spectrometry and Molecular Networking Exploring the rumen fluid metabolome using liquid chromatography-high-resolution mass spectrometry and Molecular Networking, Published online: 19 December 2018; doi:10.1038/s41598-018-36196-4 Exploring the rumen fluid metabolome using liquid chromatography-high-resolution mass spectrometry and Molecular Networking
    Electronic ISSN: 2045-2322
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  • 75
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-20
    Description: Soft Matter , 2019, Advance Article DOI : 10.1039/C8SM01661E, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Melissa Rinaldin, Ruben W. Verweij, Indrani Chakraborty, Daniela J. Kraft Careful tuning of the experimental parameters involved in preparing colloid supported lipid bilayers enables the self-assembly of flexible structures. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1744-683X
    Electronic ISSN: 1744-6848
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
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  • 76
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-21
    Description: Chem. Commun. , 2018, Accepted Manuscript DOI : 10.1039/C8CC08653B, Feature Article Hui-Seon Kim, Anders Hagfeldt, Nam-Gyu Park Perovskite solar cells (PSCs) has reached a certified 23.3% efficiency in 2018 by boosting their surprisingly high open-circuit voltage (VOC) and photocurrent. The suppressed recombination in PSCs significantly cut down... The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1359-7345
    Electronic ISSN: 1364-548X
    Topics: Chemistry and Pharmacology
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  • 77
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-21
    Description: Green Chem. , 2018, Accepted Manuscript DOI : 10.1039/C8GC03451F, Paper Xianlang Chen, Xing Zhong, bowen yuan, suiqin li, Yongbing Gu, qiaoqiao zhang, Gui-lin Zhuang, Xiaonian Li, Shengwei Deng, Jian-guo Wang Selective electrocatalytic oxidation (ECO) of alcohols to aldehydes or acids is an environmentally and economically method in modern industries. Herein, tunable holes and vacancies in nickel hydroxide (h-Ni(OH)2) by Ostwald... The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1463-9262
    Electronic ISSN: 1463-9270
    Topics: Chemistry and Pharmacology
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  • 78
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-21
    Description: Green Chem. , 2019, Advance Article DOI : 10.1039/C8GC03094D, Paper Raphael H. Lam, Caitlin M. A. McQueen, Indrek Pernik, Roy T. McBurney, Anthony F. Hill, Barbara A. Messerle Selective formylation and methylation of amines using low pressure CO 2 as a carbon source; mechanistic studies, time course and reaction scope. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1463-9262
    Electronic ISSN: 1463-9270
    Topics: Chemistry and Pharmacology
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-21
    Description: by Xiaojian Ye, Guoqiang Zhang, Haibin Chen, Yong Li
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-21
    Description: by Shiro Hayashi, Tsutomu Nishida, Tokuhiro Matsubara, Naoto Osugi, Aya Sugimoto, Kei Takahashi, Kaori Mukai, Dai Nakamatsu, Masashi Yamamoto, Koji Fukui, Masami Inada
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-21
    Description: by Peng Tang, Jie Wu, Hou Liu, Youcai Liu, Xingding Zhou
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 82
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-21
    Description: by Aditi Singh, Adrienne Vancura, Rafal K. Woycicki, Daniel J. Hogan, Alan G. Hendrick, Mariusz Nowacki
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 83
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-21
    Description: by Lucas Buyon, Randall Slaven, Paul M. Emerson, Jonathan King, Oscar Debrah, Agatha Aboe, Ernesto Ruiz-Tiben, E. Kelly Callahan Trachoma and Guinea Worm Disease (GWD) are neglected tropical diseases (NTD) slated for elimination as a public health problem and eradication respectively by the World Health Organization. As these programs wind down, uncovering the last cases becomes an urgent priority. In 2010, Ghana Health Services, along with The Carter Center, Sightsavers, and other partners, conducted integrated case searches for both GWD and the last stage of trachoma disease, trachomatous trichiasis (TT), as well as providing surgical treatment for TT to meet elimination (and eradication targets). House to house case searches for both diseases were conducted and two case management strategies were explored: a centralized referral to services method and a Point of Care (POC) delivery method. 835 suspected TT cases were discovered in the centralized method, of which 554 accepted surgery. 482 suspected TT cases were discovered in the POC method and all TT cases accepted surgery. The cost per TT case examined was lower in the POC searches compared to the centralized searches ($19.97 in the POC searches and $20.85 in the centralized searches). Both strategies resulted in high surgical uptake for TT surgery, with average uptakes of 72.4% and 83.9% for the centralized and POC searches respectively. We present here that house to house case searches offering services at POC are feasible and a potential tool for elimination and eradication programs nearing their end.
    Print ISSN: 1935-2727
    Electronic ISSN: 1935-2735
    Topics: Medicine
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  • 84
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-21
    Description: by Cannan Yi, Kai Way Li, Fan Tang, Huali Zuo, Liang Ma, Hong Hu
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 85
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-21
    Description: by Gregory P. Copenhaver, Bruce Weir, Mark Rothstein, Hua Tang, Scott M. Williams, Gregory S. Barsh
    Print ISSN: 1553-7390
    Electronic ISSN: 1553-7404
    Topics: Biology
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  • 86
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-21
    Description: by Dong Hui Lim, Jisang Han, Tae-Young Chung, Sewoong Kang, Hyeon Woo Yim, on behalf of The Epidemiologic Survey Committee of the Korean Ophthalmologic Society
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 87
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-21
    Description: by Fernando Caravaggio, Pontus Plavén-Sigray, Granville James Matheson, Eric Plitman, M. Mallar Chakravarty, Jacqueline Borg, Ariel Graff-Guerrero, Simon Cervenka High levels of trait impulsivity are considered a risk factor for substance abuse and drug addiction. We recently found that non-planning trait impulsivity was negatively correlated with post-commissural putamen volumes in men, but not women, using the Karolinska Scales of Personality (KSP). Here, we attempted to replicate this finding in an independent sample using an updated version of the KSP: the Swedish Universities Scales of Personality (SSP). Data from 88 healthy male participants (Mean Age: 28.16±3.34), who provided structural T1-weighted magnetic resonance images (MRIs) and self-reported SSP impulsivity scores, were analyzed. Striatal sub-region volumes were acquired using the Multiple Automatically Generated Templates (MAGeT-Brain) algorithm. Contrary to our previous findings trait impulsivity measured using SSP was not a significant predictor of post-commissural putamen volumes (β = .14, df = 84, p = .94). A replication Bayes Factors analysis strongly supported this null result. Consistent with our previous findings, secondary exploratory analyses found no relationship between ventral striatum volumes and SSP trait impulsivity (β = -.05, df = 84, p = .28). An exploratory analysis of the other striatal compartments showed that there were no significant associations with trait impulsivity. While we could not replicate our previous findings in the current sample, we believe this work will aide future studies aimed at establishing meaningful brain biomarkers for addiction vulnerability in healthy humans.
    Electronic ISSN: 1932-6203