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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters B 294 (1992), S. 466-478 
    ISSN: 0370-2693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters B 317 (1993), S. 474-484 
    ISSN: 0370-2693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, Advance Article DOI : 10.1039/C8CC07907B, Feature Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Felix D. Bobbink, Antoine P. van Muyden, Paul J. Dyson The strategies and challenges in the preparation of fully renewable materials prepared from CO 2 and biomass enabled by catalysis are presented. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 4
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2018, Accepted Manuscript DOI : 10.1039/C8CC08511K, Communication Tian Tian, Min Zheng, Junqi Lin, Xiangyu Meng, Yong Ding In this study, we present an ingenious design of Fe-modulated nickel hydroxides hollw nanocubes with systematically engineered structure. Sample of Ni0.75Fe0.25(OH)x exhibits good O2 evolution activity, which should be attributed... The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 5
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2018, Accepted Manuscript DOI : 10.1039/C8CC08875F, Communication Andrej Babic, Vassily Vorobiev, Gregor Trefalt, Lindsey a Crowe, Lothar Helm, Jean-Paul Vallee, Eric Allémann A synthetic nano building block endowed with amphiphilic properties and chelated gadolinium is presented. Spontaneous self-assembly into small 12 nm corona-core stealth Gd-micelles with inherently high gadolinium loading occurs in... The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 6
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2018, Accepted Manuscript DOI : 10.1039/C8CC08594C, Communication Thomas Duhamel, Kilian Muniz A new method for the formation of γ– and δ–lactones from carboxylic acids through the direct conversion of benzylic C-H to C-O bonds is described. The reaction is conveniently induced... The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 7
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2018, Accepted Manuscript DOI : 10.1039/C8CC09121H, Communication Daiki Hayashi, Nobuto Yoshinari, Takumi Konno The treatment of [Co(D- or L-ebp)] – with CdX 2 (X = Br – , I – ) gave a cyclic Co III 3 Cd II 3 complex with a 12-membered metalloring, [Cd 3 X 3 {Co(D- or L-ebp)} 3 ] (D 3 - or L 3 - 1 X ). The use of... The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 8
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2018, Accepted Manuscript DOI : 10.1039/C8CC08048H, Communication Keita Nakajima, Hiroki Miyaoka, Kenichi Kojima, Takayuki Ichikawa, Yoshitsugu Kojima Ammonia absorption process of sodium borohydride for ammonia storage has been studied by using operando NMR and FT-IR measurements under various ammonia pressures. As a result, the characteristic variation of... The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 9
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, Advance Article DOI : 10.1039/C8CC08562E, Communication Andrea Angeli, Damiano Tanini, Alessio Nocentini, Antonella Capperucci, Marta Ferraroni, Paola Gratteri, Claudiu T. Supuran Aryl selenols effectively inhibit carbonic anhydrase. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 10
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, Advance Article DOI : 10.1039/C8CC07693F, Communication Qian Ma, Hui Zhang, Jinxing Chen, Shaojun Dong, Youxing Fang Excellent anti-fatigue performance of the fluorescence switching device based on electrochromic material Prussian blue and fluorophore CdTe quantum dots was realized. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 11
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, 55 ,71-74 DOI : 10.1039/C8CC06526H, Communication Chang Sup Kim, Hye Ryoung Heo, Jeong Hyun Seo, Hyung Joon Cha A novel strategy for on-chip enzymatic glycosylation of complex glycans and direct analysis of glycan-related interactions is reported. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 12
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, 55 ,55-58 DOI : 10.1039/C8CC08287A, Communication Nathaniel M. Bingham, Peter J. Roth Radical ring-opening polymerization of a thionolactone gives degradable thioester-functional polymers. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 13
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, Advance Article DOI : 10.1039/C8CC07903J, Communication Yiling Zhong, Binbin Chu, Xin Bo, Yao He, Chuan Zhao Three-dimensional fluorescent silicon-based nanoscale networks (SiNNs) possess unusual anti-photobleaching properties, owing to a unique electronic structure system. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 14
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, 55 ,63-66 DOI : 10.1039/C8CC08866G, Communication Yan Li, Longjie Li, Xunbo Lu, Yulong Bai, Yufan Wang, Yuzhou Wu, Fangrui Zhong Inspired by the heme iron-catalyzed radical insertion of dioxygen to the tryptophan indole ring, herein we utilize alkylperoxy radical species as a coupling partner to trigger a peroxycyclization of readily accessible tryptophan derivatives and enable the first synthesis of peroxypyrroloindolenines. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 15
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, 55 ,67-70 DOI : 10.1039/C8CC08346K, Communication Wenhuan Huang, Xuepeng Zhang, Biao Chen, Hui Miao, Carl O. Trindle, Yucai Wang, Yi Luo, Guoqing Zhang Boosting triplet activity by introducing an electron donor in BF 2 dbm proved the charge-transfer mediated ISC process in the oxygen-bridged donor-sp 3 -acceptor systems. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 16
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, 55 ,47-50 DOI : 10.1039/C8CC08501C, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Santanu Panja, Dave J. Adams Kinetic control over supramolecular gelation by increasing the pH can be achieved using an enzymatic reaction. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 17
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, 55 ,59-62 DOI : 10.1039/C8CC09024F, Communication Yifan Ping, Taiwei Chang, Kang Wang, Jingfeng Huo, Jianbo Wang A new method for the synthesis of furyl-substituted alkenylboronates has been developed by palladium-catalyzed oxidative borylation reaction of conjugated enynones. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 18
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, 55 ,43-46 DOI : 10.1039/C8CC08456D, Communication Dooyoung Kim, Gihyun Lee, Sojin Oh, Moonhyun Oh Atypical unbalanced MOF-on-MOF growth is demonstrated for the production of a lopsided core–shell of MIL-88B@MIL-88A with mismatched cell parameters. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 19
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, 55 ,11-26 DOI : 10.1039/C8CC08854C, Feature Article Theocharis C. Stamatatos, Eva Rentschler A new synthetic route to structurally novel and magnetically interesting 3d-metal azido clusters and coordination polymers is presented; the key reagent for the preparation of solely azido-bridged molecule-based species is the organic azide precursor Me 3 SiN 3 . The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 20
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, 55 ,35-38 DOI : 10.1039/C8CC07298A, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Tamara D. McFarlane, Catherine S. De Castro, Peter J. Holliman, Matthew L. Davies We demonstrate improved performance and colour control of tri-bromide perovskite through co-sensitisation with organic dyes. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 21
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, 55 ,31-34 DOI : 10.1039/C8CC07120A, Communication Mohamed H. Hassan, Ahmed B. Soliman, Worood A. Elmehelmey, Arwa A. Abugable, Stavros G. Karakalos, Mady Elbahri, Abdou Hassanien, Mohamed H. Alkordi UiO-66-NH 2 was constructed on G sheets, metallated with Ni( II ) ions, and used as a precursor to deposit a highly active water oxidation catalyst in an electrochemical surface restructuring process. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 22
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, 55 ,39-42 DOI : 10.1039/C8CC07985D, Communication Yang Xu, Lianghua Xie, Jiahong Xie, Yu Liu, Wei Chen Pg3R, a natural anthocyanin from strawberry, is identified as a novel α-glucosidase inhibitor and the SAR was systematically illustrated. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 23
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, Advance Article DOI : 10.1039/C8CC09224A, Communication Hiroyuki Suga, Masahiro Yoshiwara, Takaaki Yamaguchi, Takashi Bando, Mizuki Taguchi, Ayano Inaba, Yuichi Goto, Ayaka Kikuchi, Kennosuke Itoh, Yasunori Toda The asymmetric 1,3-dipolar cycloaddition between diazo imine-derived cyclic azomethine ylides and acryloylpyrazolidinone using a dual catalytic system is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 24
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: CrystEngComm , 2019, Advance Article DOI : 10.1039/C8CE90194E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Song Jiang, Binghui Ge, Bojia Xu, Qinggang Wang, Baobao Cao To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Electronic ISSN: 1466-8033
    Topics: Geosciences , Physics
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  • 25
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: CrystEngComm , 2019, 21 ,34-40 DOI : 10.1039/C8CE01475B, Paper Hai Dang Ngo, Thien Duc Ngo, Akemi Tamanai, Kai Chen, Nguyen Thanh Cuong, Orjan S. Handegard, Annemarie Pucci, Naoto Umezawa, Toshihide Nabatame, Tadaaki Nagao Iron( III ) titanates are composed of earth-abundant elements and are attracting rapidly growing interest as highly promising candidates for solar-energy as well as optoelectronics applications. The content of this RSS Feed (c) The Royal Society of Chemistry
    Electronic ISSN: 1466-8033
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  • 26
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: CrystEngComm , 2019, 21 ,10-22 DOI : 10.1039/C8CE01391H, Highlight Boris A. Zakharov, Elena V. Boldyreva High pressure offers insight into the mechanisms of a wide range of solid-state phenomena occurring under atmospheric pressure conditions. The content of this RSS Feed (c) The Royal Society of Chemistry
    Electronic ISSN: 1466-8033
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  • 27
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2018, Accepted Manuscript DOI : 10.1039/C8CC09544B, Communication Shuangshuang Long, Qinglong Qiao, Fei Deng, Lu Miao, Juyoung Yoon, Zhaochao Xu The imidazolium-pyrene self-assembling nanoprobes can rapidly discriminated four types of surfactants. The surfactants disassembled the probes to turn on significant fluorescence and transform between pyrene monomer and excimer, generating a... The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 28
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Dalton Trans. , 2018, Accepted Manuscript DOI : 10.1039/C8DT04684K, Paper Ping Li, Zexing Cao The cycloaddition of CO 2 and epoxide catalysed by the metalloporphyrin (IL-M(TPP)) and metallocorrole (IL-M(Cor)) with the imidazolium bromide has been explored by extensive density functional theory calculations. Possible mechanisms and... The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1477-9226
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  • 29
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Dalton Trans. , 2018, Accepted Manuscript DOI : 10.1039/C8DT04458A, Paper Rui-Lei Wang, Dong-Peng Li, Lu-Jie Wang, Xiao Zhang, Zi-Yan Zhou, Jing-Lin Mou, Zhong-Min Su Covalent Organic Framework (COF) featured unique light porous structure, and silver nanoparticles featured high efficiency in degradation of environmental pollutants. However, the field of combination of COF with silver nanoparticles... The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 30
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Dalton Trans. , 2018, Accepted Manuscript DOI : 10.1039/C8DT04263B, Paper Gowtham Subramanian, Abdul Sadeer, Kalyani Mukherjee , Tadayuki Kojima, Pallavi Tripathi , Renugah Naidu , Shan Wen Tay, Jia Hao Pang, Sumod A Pullarkat, Rajesh C Das Owing to their lipophilic nature and chemical stability, ferrocene and its derivatives have been widely explored as antimicrobial agents, in combination with other active chemical ‘war heads’. A prime example... The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 31
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Commun. , 2019, 55 ,27-30 DOI : 10.1039/C8CC08413K, Communication Yufu Tang, Yuanyuan Li, Zhen Wang, Feng Pei, Xiaoming Hu, Yu Ji, Xiang Li, Hui Zhao, Wenbo Hu, Xiaomei Lu, Quli Fan, Wei Huang A nitric-oxide-activatable organic semiconducting nanoprobe was developed for in vivo , in situ , real-time and non-invasive NIR-II fluorescence monitoring of drug-dose-dependent hepatotoxicity. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 32
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Dalton Trans. , 2018, Accepted Manuscript DOI : 10.1039/C8DT04935A, Communication Yoshiko Ashida, Yumehiro Manabe, Shota Yoshioka, Tomoki Yoneda, Yasuhide Inokuma Structurally flexible oligoisopyrazole molecules were self-assembled into discrete complexes with structural diversity upon palladium coordination. Structural convergence was controlled by stoichiometry change to induce stepwise metal coordination of isopyrazole subunits.... The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 33
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Dalton Trans. , 2019, Advance Article DOI : 10.1039/C8DT04651D, Communication Min Chen, Shengjie Jiang, Laurent Maron, Xin Xu Transition metal-induced dehydrogenative homocoupling of zinc( II ) hydrides to a zinc–zinc bonded complex has been achieved. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 34
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Dalton Trans. , 2019, Advance Article DOI : 10.1039/C8DT04214D, Paper Pascal G. Yot, Mohammad Wahiduzzaman, Erik Elkaim, Pierre Fertey, Paul Fabry, Christian Serre, Guillaume Maurin The functionalization of the metal–organic framework MIL-47(V IV ) with ligand bearing bulky functional group –CF3 has been shown as a promising route to enhance the mechanical energy storage performances of this family of hybrid porous materials. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 35
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Chem. Sci. , 2019, Accepted Manuscript DOI : 10.1039/C8SC04701D, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Yuan Yuan, Weiben Chen, Zhe Ma, Yakui Deng, Ying Chen, Yulan Chen, Wenping Hu With the combination of mechanochemiluminescence from 1,2-dioxetane coupled polymers and the granulated conjugated microporous polymer (CMP) nanosheets, a new kind of filling-type mechanolumninescent polymer composites were developed. Herein, polymeric 1,2-dioxetane... The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 2041-6520
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  • 36
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Green Chem. , 2018, Accepted Manuscript DOI : 10.1039/C8GC03180K, Paper Xiaofeng Zhang, Xiao-Ming Ma, Weiqi Qiu, Jason Evans, Wei Zhang A one-pot [4+2] annulation involving aldol, aza-Witting and dehydrofluorination reactions is developed for the synthesis of substituted quinolin-4-ols including analogs bearing CF2H, CF3, and C2F5 groups. This simple and highly... The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1463-9262
    Electronic ISSN: 1463-9270
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  • 37
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Green Chem. , 2019, Advance Article DOI : 10.1039/C8GC03075H, Paper Juncheng Wang, Renfeng Nie, Ling Xu, Xilei Lyu, Xiuyang Lu Earth-abundant magnetic cobalt is highly efficient for CTH of oleic acid with isopropanol as a hydrogen donor, affording 100% conversion as well as 91.9% octadecanol yield at 200 °C, which can be ascribed to the synergistic effect between Co δ + and Co 0 . To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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  • 38
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    International Union of Crystallography (IUCr)
    In: IUCrJ
    Publication Date: 2018-12-19
    Description: The generation and motion of crystalline defects during plastic deformation are critical processes that determine the mechanical properties of a crystal. The types of defect generated are not only related to the symmetry of a crystal but also associated with the symmetry-breaking process during deformation. Proposed here is a new mathematical framework to capture the intrinsic coupling between crystal symmetry and deformation-induced symmetry breaking. Using a combination of group theory and graph theory, a general approach is demonstrated for the systematic determination of the types of crystalline defect induced by plastic deformation, through the construction of a crystal deformation group and a deformation pathway graph. The types of defect generated in the deformation of a face-centered cubic crystal are analyzed through the deformation pathway graph and compared with experimental observations.
    Keywords: crystal deformationcrystalline defectsgroup theoryCayley graph
    Electronic ISSN: 2052-2525
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  • 39
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Environ. Sci.: Water Res. Technol. , 2018, Accepted Manuscript DOI : 10.1039/C8EW00821C, Paper Ye Zheng Yang, Nicolás M Peleato, Raymond L. Legge, Robert C Andrews Application of real-time fluorescence excitation emission matrices (EEM) as a tool for water quality assessment was investigated. A bench-scale fluorescence system with on-line monitoring capabilities was used to quantify several... The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 2053-1400
    Electronic ISSN: 2053-1419
    Topics: Energy, Environment Protection, Nuclear Power Engineering
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Dalton Trans. , 2018, Accepted Manuscript DOI : 10.1039/C8DT04397C, Paper Xue Jing Zhang, Fang-Zhe Su, Diming Chen, Peng Yu, Wan-Yin Guo, Chun-Sen Liu, Miao Du A water stable EuIII-based metal–organic framework (MOF) with dual-emission luminescent behavior, namely {[Eu4(INO)5(µ3-OH)2Cl4(H2O)]∙(NO3)∙(H2O)5}n (Eu-MOF; HINO = isonicotinic acid N-oxide), was successfully constructed by the solvothermal reaction of Eu3+ ion with... The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1477-9226
    Topics: Chemistry and Pharmacology
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    International Union of Crystallography (IUCr)
    In: IUCrJ
    Publication Date: 2018-12-19
    Description: The present article is devoted to the characterization of the structural phase transitions of the [CH3NH3][Co(COOH)3] (1) perovskite-like metal–organic compound through variable-temperature single-crystal neutron diffraction. At room temperature, compound 1 crystallizes in the orthorhombic space group Pnma (phase I). A decrease in temperature gives rise to a first phase transition from the space group Pnma to an incommensurate phase (phase II) at approximately 128 K. At about 96 K, this incommensurate phase evolves into a second phase with a sharp change in the modulation vector (phase III). At lower temperatures (ca 78 K), the crystal structure again becomes commensurate and can be described in the monoclinic space group P21/n (phase IV). Although phases I and IV have been reported previously [Boča et al. (2004). Acta Cryst. C60, m631–m633; Gómez-Aguirre et al. (2016). J. Am. Chem. Soc. 138, 1122–1125; Mazzuca et al. (2018). Chem. Eur. J. 24, 388–399], phases III and IV corresponding to the Pnma(00γ)0s0 space group have not yet been described. These phase transitions involve not only the occurrence of small distortions in the three-dimensional anionic [Co(HCOO)3]− framework, but also the reorganization of the [CH3NH3]+ counter-ions in the cavities of the structure, which gives rise to an alteration of the hydrogen-bonded network, modifying the electrical properties of compound 1.
    Keywords: phase transitionsincommensurate structuresformate ligandmultiferroic materialsaperiodic structuresmaterials scienceinorganic chemistryphase transitionsMOFs
    Electronic ISSN: 2052-2525
    Topics: Geosciences , Physics
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Lab Chip , 2019, Advance Article DOI : 10.1039/C8LC00675J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Zhengya Dong, David Fernandez Rivas, Simon Kuhn An acoustophoretic microreactor to manage particles in flow and to control the material synthesis process. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1473-0197
    Electronic ISSN: 1473-0189
    Topics: Chemistry and Pharmacology
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Lab Chip , 2018, Accepted Manuscript DOI : 10.1039/C8LC00709H, Paper Chang-Koo Yun, Jung Wook Hwang, Tae Joon Kwak, Woo-Jin Chang, Sungjae Ha, Kyuboem Han, Sanghyun Lee, Yong-Soo Choi Intracellular delivery of functional molecules such as proteins, transcription factors and DNA is effective and promising in cell-biology. However, existing transfection methods are often unsuitable to deliver big molecules into... The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1473-0197
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Lab Chip , 2019, 19 ,9-10 DOI : 10.1039/C8LC90089B, Editorial Michael L. Shuler Thought leader Michael Shuler provides an update on the Lab on a Chip organ-, body- and disease- on-a-chip thematic collection. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1473-0197
    Electronic ISSN: 1473-0189
    Topics: Chemistry and Pharmacology
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    Royal Society of Chemistry (RSC)
    Publication Date: 2018-12-19
    Description: Dalton Trans. , 2018, Accepted Manuscript DOI : 10.1039/C8DT04578J, Paper Feifei Mei, Jinfeng Zhang, Kai Dai, Guangping Zhu, Changhao Liang Recently, Cadmium selenide (CdSe) has been deeply studied because of its excellent photocatalytic hydrogen (H2) production performance. However, pure CdSe has poor stability and severe photocorrosion, which seriously affect its... The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1477-9226
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-19
    Description: Deoxyribose and deoxysugar derivatives from photoprocessed astrophysical ice analogues and comparison to meteorites Deoxyribose and deoxysugar derivatives from photoprocessed astrophysical ice analogues and comparison to meteorites, Published online: 18 December 2018; doi:10.1038/s41467-018-07693-x Sugars are known to form from the UV photoprocessing of ices under astrophysical conditions. Here, the authors report the detection of deoxyribose, the sugar of DNA, and other deoxysugars from the UV photoprocessing of H2O:CH3OH ice mixtures, which are compared with materials from carbonaceous meteorites.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-19
    Description: Source-device-independent heterodyne-based quantum random number generator at 17 Gbps Source-device-independent heterodyne-based quantum random number generator at 17 Gbps, Published online: 18 December 2018; doi:10.1038/s41467-018-07585-0 For many applications, quantum random number generation should be fast and independent from assumptions on the apparatus. Here, the authors devise and implement an approach which assumes a trusted detector but not a trusted source, and allows random bit generations at ~17 Gbps using off-the-shelf components.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-19
    Description: Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep, Published online: 18 December 2018; doi:10.1038/s41467-018-07752-3 Neural activity during REM sleep is similar to the waking state. Here, the authors measure blood volume with neurofunctional ultrasound imaging together with hippocampal neural activity during REM sleep and report that fast gamma oscillations are coupled to a brain-wide upregulation of vascular flow.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-19
    Description: HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity, Published online: 18 December 2018; doi:10.1038/s41467-018-07780-z RIG-I is a critical receptor in the induction of innate immune responses, but mutations in RIG-I can be associated with hyperactive signalling and autoimmune disease. Here Zheng et al. apply HDX-MS approaches to reveal dysregulated checkpoints that result in recognition of self-derived RNA during RIG-I mediated autoimmunity.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 50
    Publication Date: 2018-12-19
    Description: Targeting the Mycobacterium ulcerans cytochrome bc 1 : aa 3 for the treatment of Buruli ulcer Targeting the 〈i〉Mycobacterium ulcerans〈/i〉 cytochrome 〈i〉bc〈/i〉〈sub〉1〈/sub〉:〈i〉aa〈/i〉〈sub〉3〈/sub〉 for the treatment of Buruli ulcer, Published online: 18 December 2018; doi:10.1038/s41467-018-07804-8 Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU). Existing anti-tubercular drugs have been used to treat the condition with varying success. Here, the authors show that a clinical-stage drug candidate for tuberculosis, Q203, is effective at killing M. ulcerans and is a promising therapeutic candidate for BU.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-19
    Description: Ultimate limit in size and performance of WSe 2 vertical diodes Ultimate limit in size and performance of WSe〈sub〉2〈/sub〉 vertical diodes, Published online: 18 December 2018; doi:10.1038/s41467-018-07820-8 Vertical charge transport through homogeneous WSe2 layers can be effectively tuned by the layer number and contacting metals deposited. Here, the authors report WSe2 vertical diodes with superior device performance characteristics based on variable WSe2 thickness and gadolinium and platinum contact metals.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    International Union of Crystallography (IUCr)
    In: IUCrJ
    Publication Date: 2018-12-19
    Description: The defect structure of γ-Al2O3 derived from boehmite was investigated using a combination of selected-area electron diffraction (SAED) and powder X-ray diffraction (XRD). Both methods confirmed a strong dependence of the diffraction line broadening on the diffraction indices known from literature. The analysis of the SAED patterns revealed that the dominant structure defects in the spinel-type γ-Al2O3 are antiphase boundaries located on the lattice planes (00l), which produce the sublattice shifts {{1}\over{4}}\langle 10{\overline 1}\rangle. Quantitative information about the defect structure of γ-Al2O3 was obtained from the powder XRD patterns. This includes mainly the size of γ-Al2O3 crystallites and the density of planar defects. The correlation between the density of the planar defects and the presence of structural vacancies, which maintain the stoichiometry of the spinel-type γ-Al2O3, is discussed. A computer routine running on a fast graphical processing unit was written for simulation of the XRD patterns. This routine calculates the atomic positions for a given kind and density of planar defect, and simulates the diffracted intensities with the aid of the Debye scattering equation.
    Keywords: γ-aluminamicrostructure defectsantiphase boundariesrotational boundariesselected-area electron diffractionpowder X-ray diffractionDebye equationanisotropic broadening
    Electronic ISSN: 2052-2525
    Topics: Geosciences , Physics
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    Nature Publishing Group (NPG)
    Publication Date: 2018-12-19
    Description: Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages, Published online: 18 December 2018; doi:10.1038/s41467-018-07788-5 The origins of lineage correlations and heterogeneity in division and apoptosis times among single cells are incompletely understood. Here, a new lineage tracking data analysis approach reveals that circadian oscillations may underlie cell fate control and explain the observed correlation structures.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Institute of Physics (IOP)
    Publication Date: 2018-12-19
    Description: Spontaneous Raman processes in cold atoms have been widely used in the past decade for generating single photons. Here, we present a method to optimise their efficiencies for given atomic coherences and optical depths. We give a simple and complete recipe that can be used in present-day experiments, attaining near-optimal single photon emission.
    Electronic ISSN: 1367-2630
    Topics: Physics
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    Institute of Physics (IOP)
    Publication Date: 2018-12-19
    Description: Recent experiments indicated that both layered Bi 2 O 2 Se and Bi 2 O 2 Te are promising thermoelectric materials with low thermal conductivities. However, theoretical study on the thermoelectric properties, especially the phonon transport properties, is rare. In order to understand the thermoelectric transport mechanism, we here investigate the electron and phonon transport properties by using the first-principles calculations combined with the Boltzmann transport theory. Our results indicate that both Bi 2 O 2 Se and Bi 2 O 2 Te are semiconductors with indirect energy gaps of 0.87 eV and 0.21 eV within spin–orbit coupling, respectively. Large Seebeck coefficient and power factor are found in the p -type than the n -type for both compounds. Low lattice thermal conductivities at room temperature are obtained, 1.14 W m −1 K −1 for Bi 2 O 2 Se and 0.58 W m ...
    Electronic ISSN: 1367-2630
    Topics: Physics
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    Institute of Physics (IOP)
    Publication Date: 2018-12-19
    Description: We study nanofriction in an ion Coulomb crystal under the presence of a topological defect. We have previously observed signatures of the pinning to sliding transition i.e. the symmetry breaking at the critical point and the existence of a vibrational soft mode. Here we discuss how they depend on the position of the topological defect and how external potentials, such as anharmonic trapping potentials or differential light pressure, can be used to change the defect position. The resulting forces tend to break the intrinsic crystal symmetry, thereby reducing mode softening near the transition. We show that the topological defect mode is sensitive to differential forces at the 10 −24 N level. We find that the local structure and position of the topological defect is essential for the presence of the soft mode and illustrate how the defect changes its properties, when it moves through the crystal.
    Electronic ISSN: 1367-2630
    Topics: Physics
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    Institute of Physics (IOP)
    Publication Date: 2018-12-19
    Description: Color centers in diamond are promising solid-state qubits for scalable quantum photonics applications. Amongst many defects, those with inversion symmetry are of an interest due to their promising optical properties. In this work, we demonstrate a maskless implantation of an array of bright, single germanium vacancy (GeV) centers in diamond. Employing the direct focused ion beam technique, single GeV emitters are engineered with the spatial accuracy of tens of nanometers. The single GeV creation ratio reaches as high as 53% with the dose of 200 Ge + ions per spot. The presented fabrication method is promising for future nanofabrication of integrated photonic structures with GeV emitters as a leading platform for spin-spin interactions.
    Electronic ISSN: 1367-2630
    Topics: Physics
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    American Physical Society (APS)
    Publication Date: 2018-12-19
    Description: Author(s): Dan Cogan, Oded Kenneth, Netanel H. Lindner, Giora Peniakov, Caspar Hopfmann, Dan Dalacu, Philip J. Poole, Pawel Hawrylak, and David Gershoni It may be possible to create a confined electronic spin qubit with a long coherence time in a semiconductor quantum dot, greatly increasing the utility of quantum dots as light-matter interfaces in quantum information processing applications. [Phys. Rev. X 8, 041050] Published Tue Dec 18, 2018
    Electronic ISSN: 2160-3308
    Topics: Physics
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    Institute of Physics (IOP)
    Publication Date: 2018-12-19
    Description: We have developed a universal method to form the reference signal for the stabilization of arbitrary atomic clocks based on Ramsey spectroscopy. Our approach uses an interrogation scheme of the atomic system with two different Ramsey periods and a specially constructed combined error signal (CES) computed by subtracting two error signals with the appropriate calibration factor. CES spectroscopy allows for perfect elimination of probe-induced light shifts and does not suffer from the effects of relaxation, time-dependent pulse fluctuations and phase-jump modulation errors and other imperfections of the interrogation procedure. The method is simpler than recently developed auto-balanced Ramsey spectroscopy techniques (Sanner et al 2018 Phys. Rev. Lett. 120 053602; Yudin et al 2018 Phys. Rev. Appl. 9 054034), because it uses a single error signal that feeds back on the clock frequency. The use of CES is a general technique that can be appli...
    Electronic ISSN: 1367-2630
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    American Physical Society (APS)
    In: Physics
    Publication Date: 2018-12-19
    Description: A hybrid quantum-classical computing algorithm could solve a basic computer science problem faster than a classical computer. [Physics] Published Tue Dec 18, 2018
    Electronic ISSN: 1539-0748
    Topics: Physics
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    Institute of Physics (IOP)
    Publication Date: 2018-12-19
    Description: Ultracold ground-state molecules can be formed from ultracold atoms via photoassociation followed by a spontaneous emission process. Typically, the molecular products are distributed over a range of final states. Here, we propose to use an optical cavity with high cooperativity to selectively enhance the population of a pre-determined final state by controlling the spontaneous emission. During this process, a photon will be emitted into the cavity mode. Detection of this photon heralds a single reaction. We discuss the efficiency and the dynamics of cavity-assisted molecule formation in the frame of realistic parameters that can be achieved in current ultracold-atom setups. In particular, we consider the production of Rb 2 molecules in the a 3 Σ u triplet ground state. Moreover, when working with more than two atoms in the cavity, collective enhancement effects in chemistry should be observable.
    Electronic ISSN: 1367-2630
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-19
    Description: by Jonas F. Ludvigsson, Donghao Lu, Lennart Hammarström, Sven Cnattingius, Fang Fang Background Small for gestational age (SGA) has been associated with increased risks of stillbirth and neonatal mortality, but data on long-term childhood mortality are scarce. Maternal antenatal care, including globally reducing the risk of SGA birth, may be key to achieving the Millennium Development Goal of reducing under-5 mortality. We therefore aimed to examine the association between SGA and mortality from 28 days to
    Print ISSN: 1549-1277
    Electronic ISSN: 1549-1676
    Topics: Medicine
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-19
    Description: by Wang Xi, Michael A. Beer We report an experimental design issue in recent machine learning formulations of the enhancer-promoter interaction problem arising from the fact that many enhancer-promoter pairs share features. Cross-fold validation schemes which do not correctly separate these feature sharing enhancer-promoter pairs into one test set report high accuracy, which is actually arising from high training set accuracy and a failure to properly evaluate generalization performance. Cross-fold validation schemes which properly segregate pairs with shared features show markedly reduced ability to predict enhancer-promoter interactions from epigenomic state. Parameter scans with multiple models indicate that local epigenomic features of individual pairs of enhancers and promoters cannot distinguish those pairs that interact from those which do with high accuracy, suggesting that additional information is required to predict enhancer-promoter interactions.
    Print ISSN: 1553-734X
    Electronic ISSN: 1553-7358
    Topics: Biology , Computer Science
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    Publication Date: 2018-12-19
    Description: Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity, Published online: 18 December 2018; doi:10.1038/s41467-018-07199-6 More than 18 human papillomaviruses (HPV) are associated with cervical cancer, and ideally vaccines should protect from all of them. Here, the authors engineer a triple-type, chimeric HPV vaccine, using loop swapping, that elicits robust neutralizing antibody titers in mice and non-human primates.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-19
    Description: by Stephanie Lauer, Grace Avecilla, Pieter Spealman, Gunjan Sethia, Nathan Brandt, Sasha F. Levy, David Gresham Copy number variants (CNVs) are a pervasive source of genetic variation and evolutionary potential, but the dynamics and diversity of CNVs within evolving populations remain unclear. Long-term evolution experiments in chemostats provide an ideal system for studying the molecular processes underlying CNV formation and the temporal dynamics with which they are generated, selected, and maintained. Here, we developed a fluorescent CNV reporter to detect de novo gene amplifications and deletions in individual cells. We used the CNV reporter in Saccharomyces cerevisiae to study CNV formation at the GAP1 locus, which encodes the general amino acid permease, in different nutrient-limited chemostat conditions. We find that under strong selection, GAP1 CNVs are repeatedly generated and selected during the early stages of adaptive evolution, resulting in predictable dynamics. Molecular characterization of CNV-containing lineages shows that the CNV reporter detects different classes of CNVs, including aneuploidies, nonreciprocal translocations, tandem duplications, and complex CNVs. Despite GAP1 ’s proximity to repeat sequences that facilitate intrachromosomal recombination, breakpoint analysis revealed that short inverted repeat sequences mediate formation of at least 50% of GAP1 CNVs. Inverted repeat sequences are also found at breakpoints at the DUR3 locus, where CNVs are selected in urea-limited chemostats. Analysis of 28 CNV breakpoints indicates that inverted repeats are typically 8 nucleotides in length and separated by 40 bases. The features of these CNVs are consistent with origin-dependent inverted-repeat amplification (ODIRA), suggesting that replication-based mechanisms of CNV formation may be a common source of gene amplification. We combined the CNV reporter with barcode lineage tracking and found that 10 2 –10 4 independent CNV-containing lineages initially compete within populations, resulting in extreme clonal interference. However, only a small number (18–21) of CNV lineages ever constitute more than 1% of the CNV subpopulation, and as selection progresses, the diversity of CNV lineages declines. Our study introduces a novel means of studying CNVs in heterogeneous cell populations and provides insight into their dynamics, diversity, and formation mechanisms in the context of adaptive evolution.
    Print ISSN: 1544-9173
    Electronic ISSN: 1545-7885
    Topics: Biology
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-19
    Description: by Heleen Riper, Adriaan Hoogendoorn, Pim Cuijpers, Eirini Karyotaki, Nikolaos Boumparis, Adriana Mira, Gerhard Andersson, Anne H. Berman, Nicolas Bertholet, Gallus Bischof, Matthijs Blankers, Brigitte Boon, Leif Boß, Håvar Brendryen, John Cunningham, David Ebert, Anders Hansen, Reid Hester, Zarnie Khadjesari, Jeannet Kramer, Elizabeth Murray, Marloes Postel, Daniela Schulz, Kristina Sinadinovic, Brian Suffoletto, Christopher Sundström, Hein de Vries, Paul Wallace, Reinout W. Wiers, Johannes H. Smit Background Face-to-face brief interventions for problem drinking are effective, but they have found limited implementation in routine care and the community. Internet-based interventions could overcome this treatment gap. We investigated effectiveness and moderators of treatment outcomes in internet-based interventions for adult problem drinking (iAIs). Methods and findings Systematic searches were performed in medical and psychological databases to 31 December 2016. A one-stage individual patient data meta-analysis (IPDMA) was conducted with a linear mixed model complete-case approach, using baseline and first follow-up data. The primary outcome measure was mean weekly alcohol consumption in standard units (SUs, 10 grams of ethanol). Secondary outcome was treatment response (TR), defined as less than 14/21 SUs for women/men weekly. Putative participant, intervention, and study moderators were included. Robustness was verified in three sensitivity analyses: a two-stage IPDMA, a one-stage IPDMA using multiple imputation, and a missing-not-at-random (MNAR) analysis. We obtained baseline data for 14,198 adult participants (19 randomised controlled trials [RCTs], mean age 40.7 [SD = 13.2], 47.6% women). Their baseline mean weekly alcohol consumption was 38.1 SUs (SD = 26.9). Most were regular problem drinkers (80.1%, SUs 44.7, SD = 26.4) and 19.9% (SUs 11.9, SD = 4.1) were binge-only drinkers. About one third were heavy drinkers, meaning that women/men consumed, respectively, more than 35/50 SUs of alcohol at baseline (34.2%, SUs 65.9, SD = 27.1). Post-intervention data were available for 8,095 participants. Compared with controls, iAI participants showed a greater mean weekly decrease at follow-up of 5.02 SUs (95% CI −7.57 to −2.48, p 〈 0.001) and a higher rate of TR (odds ratio [OR] 2.20, 95% CI 1.63–2.95, p 〈 0.001, number needed to treat [NNT] = 4.15, 95% CI 3.06–6.62). Persons above age 55 showed higher TR than their younger counterparts (OR = 1.66, 95% CI 1.21–2.27, p = 0.002). Drinking profiles were not significantly associated with treatment outcomes. Human-supported interventions were superior to fully automated ones on both outcome measures (comparative reduction: −6.78 SUs, 95% CI −12.11 to −1.45, p = 0.013; TR: OR = 2.23, 95% CI 1.22–4.08, p = 0.009). Participants treated in iAIs based on personalised normative feedback (PNF) alone were significantly less likely to sustain low-risk drinking at follow-up than those in iAIs based on integrated therapeutic principles (OR = 0.52, 95% CI 0.29–0.93, p = 0.029). The use of waitlist control in RCTs was associated with significantly better treatment outcomes than the use of other types of control (comparative reduction: −9.27 SUs, 95% CI −13.97 to −4.57, p 〈 0.001; TR: OR = 3.74, 95% CI 2.13–6.53, p 〈 0.001). The overall quality of the RCTs was high; a major limitation included high study dropout (43%). Sensitivity analyses confirmed the robustness of our primary analyses. Conclusion To our knowledge, this is the first IPDMA on internet-based interventions that has shown them to be effective in curbing various patterns of adult problem drinking in both community and healthcare settings. Waitlist control may be conducive to inflation of treatment outcomes.
    Print ISSN: 1549-1277
    Electronic ISSN: 1549-1676
    Topics: Medicine
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-19
    Description: by Yanhui Liao, Qiuxia Wu, Brian C. Kelly, Fengyu Zhang, Yi-Yuan Tang, Qianjin Wang, Honghong Ren, Yuzhu Hao, Mei Yang, Joanna Cohen, Jinsong Tang Background China has the highest global prevalence of cigarette smokers, accounting for more than 40% of the total cigarette consumption in the world. Considering the shortage of smoking cessation services in China, and the acceptability, feasibility, and efficacy of mobile-phone-based text messaging interventions for quitting smoking in other countries, we conducted a mobile-phone-based smoking cessation study in China. Methods and findings We conducted a randomized controlled trial in China across 30 cities and provinces from August 17, 2016, to May 27, 2017. Adult smokers aged 18 years and older with the intention to quit smoking were recruited and randomized to a 12-week high-frequency messaging (HFM) or low-frequency messaging (LFM) intervention (“Happy Quit”) or to a control group in a 5:2:3 ratio. The control group received only text messages unrelated to quitting. The primary outcome was biochemically verified continuous smoking abstinence at 24 weeks. Secondary outcomes included (1) self-reported 7-day point prevalence of abstinence (i.e., not even a puff of smoke, for the last 7 days) at 1, 4, 8, 12, 16, 20, and 24 weeks; (2) self-reported continuous abstinence at 4, 12, and 24 weeks; and (3) self-reported average number of cigarettes smoked per day. A total of 1,369 participants received 12 weeks of intervention or control text messages with continued follow-up for 12 weeks. The baseline characteristics of participants among the HFM ( n = 674), LFM ( n = 284), and control ( n = 411) groups were similar. The study sample included 1,295 (94.6%) men; participants had a mean age of 38.1 (SD 9.79) years and smoked an average of 20.1 (SD 9.19) cigarettes per day. We included the participants in an intention-to-treat analysis. Biochemically verified continuous smoking abstinence at 24 weeks occurred in 44/674 participants in the HFM group (6.5%), 17/284 participants in the LFM group (6.0%), and 8/411 participants (1.9%) in the control group; participants in both the HFM (odds ratio [OR] = 3.51, 95% CI 1.64–7.55, p 〈 0.001) and the LFM (OR = 3.21, 95% CI 1.36–7.54], p = 0.002) intervention groups were more likely to quit smoking than those in the control group. However, there was no difference in quit rate between the HFM and LFM interventions. We also found that the 7-day point quit rate from week 1 to week 24 ranged from approximately 10% to more than 26% with the intervention and from less than 4% to nearly 12% without the intervention. Those who continued as smokers in the HFM group smoked 1 to 3 fewer cigarettes per day than those in the LFM group over the 24 weeks of trial. Among study limitations, the participants were able to use other smoking cessation services (although very few participants reported using them), cotinine tests can only detect smoking status for a few days, and the proportion of quitters was small. Conclusions Our findings demonstrate that a mobile-phone-based text messaging intervention (Happy Quit), with either high- or low-frequency messaging, led to smoking cessation in the present study, albeit in a low proportion of smokers, and can therefore be considered for use in large-scale intervention efforts in China. Mobile-phone-based interventions could be paired with other smoking cessation services for treatment-seeking smokers in China. Trial registration ClinicalTrials.gov NCT02693626.
    Print ISSN: 1549-1277
    Electronic ISSN: 1549-1676
    Topics: Medicine
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-19
    Description: by Katrine T. Ejlerskov, Stephen J. Sharp, Martine Stead, Ashley J. Adamson, Martin White, Jean Adams Background In response to public concerns and campaigns, some United Kingdom supermarkets have implemented policies to reduce less-healthy food at checkouts. We explored the effects of these policies on purchases of less-healthy foods commonly displayed at checkouts. Methods and findings We used a natural experimental design and two data sources providing complementary and unique information. We analysed data on purchases of small packages of common, less-healthy, checkout foods (sugary confectionary, chocolate, and potato crisps) from 2013 to 2017 from nine UK supermarkets (Aldi, Asda, Co-op, Lidl, M&S, Morrisons, Sainsbury’s, Tesco, and Waitrose). Six supermarkets implemented a checkout food policy between 2013 and 2017 and were considered intervention stores; the remainder were comparators.Firstly, we studied the longitudinal association between implementation of checkout policies and purchases taken home. We used data from a large ( n ≈ 30,000) household purchase panel of food brought home to conduct controlled interrupted time series analyses of purchases of less-healthy common checkout foods from 12 months before to 12 months after implementation. We conducted separate analyses for each intervention supermarket, using others as comparators. We synthesised results across supermarkets using random effects meta-analyses. Implementation of a checkout food policy was associated with an immediate reduction in four-weekly purchases of common checkout foods of 157,000 (72,700–242,800) packages per percentage market share—equivalent to a 17.3% reduction. This decrease was sustained at 1 year with 185,100 (121,700–248,500) fewer packages purchased per 4 weeks per percentage market share—equivalent to a 15.5% reduction. The immediate, but not sustained, effect was robust to sensitivity analysis.Secondly, we studied the cross-sectional association between checkout food policies and purchases eaten without being taken home. We used data from a smaller ( n ≈ 7,500) individual purchase panel of food bought and eaten ‘on the go’. We conducted cross-sectional analyses comparing purchases of common checkout foods in 2016–2017 from supermarkets with and without checkout food policies. There were 76.4% (95% confidence interval 48.6%–89.1%) fewer annual purchases of less-healthy common checkout foods from supermarkets with versus without checkout food policies.The main limitations of the study are that we do not know where in the store purchases were selected and cannot determine the effect of changes in purchases on consumption. Other interventions may also have been responsible for the results seen. Conclusions There is a potential impact of checkout food polices on purchases. Voluntary supermarket-led activities may have public health benefits.
    Print ISSN: 1549-1277
    Electronic ISSN: 1549-1676
    Topics: Medicine
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    Public Library of Science (PLoS)
    In: PLoS ONE
    Publication Date: 2018-12-19
    Description: by Tormod Rebnord, Truls Østbye, Blandina Theophil Mmbaga, Bariki Mchome, Rolv Terje Lie, Anne Kjersti Daltveit
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 70
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    In: PLoS ONE
    Publication Date: 2018-12-19
    Description: by Martina Tinzl, Binshen Chen, Shao-Yong Chen, Julius Semenas, Per-Anders Abrahamsson, Nishtman Dizeyi
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 71
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    Public Library of Science (PLoS)
    Publication Date: 2018-12-19
    Description: by Changguang Xiao, Chenxi Li, Di Di, Julien Cappelle, Lihong Liu, Xin Wang, Linlin Pang, Jinpeng Xu, Ke Liu, Beibei Li, Donghua Shao, Yafeng Qiu, Weijie Ren, Frederik Widén, Véronique Chevalier, Jianchao Wei, Xiaodong Wu, Zhiyong Ma Japanese encephalitis virus (JEV) genotype dominance has shifted to genotype I (GI) from genotype III (GIII) in China as demonstrated by molecular epidemiological surveillance. In this study, we performed a serological survey in JEV-non-vaccinated pigs to confirm JEV genotype shift at the sero-epidemiological level. The average ratio of GI/GIII infection was 1.87, suggesting co-circulation of GI and GIII infections with GI infection being more prevalent in pigs in China. To gain an insight into the reasons for this JEV genotype shift, the replication kinetics of seven recently-isolated JEV isolates including three GI strains and four GIII strains were compared in mosquito C6/36 cells, chicken fibroblast cells (DF-1) and porcine iliac artery endothelial cells (PIEC). We observed that GI strains replicated more efficiently than GIII strains in DF-1 and PIEC cells, particularly in DF-1 cells with titers reaching 22.9–225.3 fold higher than GIII strains. This shows an enhanced replication efficiency of GI viruses in avian cells. To examine this enhanced replication efficiency in vivo , young domestic ducklings were used as the animal model and inoculated with GI and GIII strains at day 2 post-hatching. We observed that GI-inoculated ducklings developed higher viremia titers and displayed a comparatively longer viremic duration than GIII-inoculated ducklings. These results conform to the hypothesis of an enhanced replication efficiency for GI viruses in birds. There are 36 amino acid differences between GI and GIII viruses, some of which may be responsible for the enhanced replication efficiency of GI viruses in birds. Based on these findings, we speculated that the enhanced replication of GI viruses in birds would have resulted in higher exposure and therefore infection in mosquitoes, which could result in an increased transmission efficiency of GI viruses in the birds-mosquitoes-birds enzootic transmission cycle, thereby contributing to JEV genotype shift.
    Print ISSN: 1935-2727
    Electronic ISSN: 1935-2735
    Topics: Medicine
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  • 72
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    In: PLoS ONE
    Publication Date: 2018-12-19
    Description: by Ki Wook Yun, Eun Hwa Choi, Hoan Jong Lee
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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  • 73
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    In: PLoS ONE
    Publication Date: 2018-12-19
    Description: by Tina Xiong, Dahlia Rohm, Rachael E. Workman, Lauren Roundtree, Carl D. Novina, Winston Timp, Marc Ostermeier Mammalian gene expression is a complex process regulated in part by CpG methylation. The ability to target methylation for de novo gene regulation could have therapeutic and research applications. We have previously developed a dCas9-MC/MN protein for targeting CpG methylation. dCas9-MC/MN is composed of an artificially split M.SssI methyltransferase (MC/MN), with the MC fragment fused to a nuclease-null CRISPR/Cas9 (dCas9). Guide RNAs directed dCas9-MC/MN to methylate target sites in E . coli and human cells but also caused some low-level off-target methylation. Here, in E . coli , we show that shortening the dCas9-MC linker increases methylation of CpG sites located at select distances from the dCas9 binding site. Although a shortened linker decreased methylation of other CpGs proximal to the target site, it did not reduce off-target methylation of more distant CpG sites. Instead, targeted mutagenesis of the methyltransferase’s DNA binding domain, designed to reduce DNA affinity, significantly and preferentially reduced methylation of such sites.
    Electronic ISSN: 1932-6203
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  • 74
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    In: PLoS ONE
    Publication Date: 2018-12-19
    Description: by Cheryl L. Barnes, Anne H. Beaudreau, Mary E. Hunsicker, Lorenzo Ciannelli Pacific Halibut ( Hippoglossus stenolepis ) support culturally and economically important fisheries in the Gulf of Alaska, though recent decreases in mean size-at-age have substantially reduced fishery yields, generating concerns among stakeholders and resource managers. Among the prevailing hypotheses for reduced size-at-age is intensified competition with Arrowtooth Flounder ( Atheresthes stomias ), a groundfish predator that exhibited nearly five-fold increases in biomass between the 1960s and mid-2010s. To assess the potential for competition between Pacific Halibut and Arrowtooth Flounder, we evaluated their degree of spatiotemporal and dietary overlap in the Gulf of Alaska using bottom trawl survey and food habits data provided by the Alaska Fisheries Science Center (NOAA; 1990 to 2017). We restricted analyses to fish measuring 30 to 69 cm fork length and used a delta modeling approach to quantify species-specific presence-absence and catch-per-unit-effort as a function of survey year, tow location, depth, and bottom temperature. We then calculated an index of spatial overlap across a uniform grid by multiplying standardized predictions of species’ abundance. Dietary overlap was calculated across the same uniform grid using Schoener’s similarity index. Finally, we assessed the relationship between spatial and dietary overlap as a measure of resource partitioning. We found increases in spatial overlap, moving from east to west in the Gulf of Alaska (eastern: 0.13 ± 0.20; central: 0.21 ± 0.11; western: 0.31 ± 0.13 SD). Dietary overlap was low throughout the study area (0.13 ± 0.20 SD). There was no correlation between spatial and dietary overlap, suggesting an absence of resource partitioning along the niche dimensions examined. This finding provides little indication that competition with Arrowtooth Flounder was responsible for changes in Pacific Halibut alHHsize-at-age in the Gulf of Alaska; however, it does not rule out competitive interactions that may have affected resource use prior to standardized data collection or at different spatiotemporal scales.
    Electronic ISSN: 1932-6203
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    In: PLoS ONE
    Publication Date: 2018-12-19
    Description: by Li Zhou, Jianxin Niu, Shaowen Quan Reverse transcription quantitative real-time PCR (RT-qPCR) is a popular adopted technique to detect gene expression, and the selection of appropriate reference genes is crucial for data normalization. In the present study, seven candidate reference genes were screened to evaluate their expression stability in various flower buds, leaf buds, tissues and cultivars of the English walnut ( Juglans regia L.) based on four algorithms (geNorm, Normfinder, Bestkeeper and RefFinder). The results demonstrated that TUA , EF1 and TUB were appropriate reference genes for flower buds at different stages of female flower buds differentiation; TUB and 18S rRNA were best for leaf buds at different stages of female flower buds differentiation; TUB and TUA were suitable for different cultivars; and ACT2 , 18S rRNA and GAPDH were useful for different tissues. Moreover, the expression of ACT was not stable among different flower buds, leaf buds and cultivars. The stability of reference genes were confirmed through the analysis of the expression of SPL18 gene. These results will contribute to a reliable normalization of gene expression in J . regia .
    Electronic ISSN: 1932-6203
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  • 76
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    In: PLoS ONE
    Publication Date: 2018-12-19
    Description: by Marilyn E. Holt, Lauren E. Salay, Elizabeth O’Brien, Jacqueline K. Barton, Walter J. Chazin The regulatory subunit of human DNA primase has a C-terminal domain (p58C) that contains a [4Fe4S] cluster and binds DNA. Previous electrochemical analysis of a p58C construct revealed that its affinity for DNA is sensitive to the redox state of the [4Fe4S] cluster. Concerns about the validity of this conclusion have been raised, based in part on differences in X-ray crystal structures of the p58C 272-464 construct used for that study and that of a N-terminally shifted p58C 266-456 construct and consequently, an assumption that p58C 272-464 has abnormal physical and functional properties. To address this controversy, a new p58C 266-464 construct containing all residues was crystallized under the conditions previously used for crystallizing p58C 272-464 , and the solution structures of both constructs were assessed using circular dichroism and NMR spectroscopy. In the new crystal structure, p58C 266-464 exhibits the same elements of secondary structure near the DNA binding site as observed in the crystal structure of p58C 272-464 . Moreover, in solution, circular dichroism and 15 N, 1 H-heteronuclear single quantum coherence (HSQC) NMR spectra show there are no significant differences in the distribution of secondary structures or in the tertiary structure or the two constructs. To validate that the two constructs have the same functional properties, binding of a primed DNA template was measured using a fluorescence-based DNA binding assay, and the affinities for this substrate were the same (3.4 ± 0.5 μM and 2.7 ± 0.3 μM, respectively). The electrochemical properties of p58C 266-464 were also measured and this p58C construct was able to engage in redox switching on DNA with the same efficiency as p58C 272-464 . Together, these results show that although p58C can be stabilized in different conformations in the crystalline state, in solution there is effectively no difference in the structure and functional properties of p58C constructs of different lengths.
    Electronic ISSN: 1932-6203
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  • 77
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    In: PLoS ONE
    Publication Date: 2018-12-19
    Description: by Katharine Kripke, Marjorie Opuni, Elijah Odoyo-June, Mathews Onyango, Peter Young, Kennedy Serrem, Vincent Ojiambo, Melissa Schnure, Peter Stegman, Emmanuel Njeuhmeli Background Kenya is 1 of 14 priority countries in Africa scaling up voluntary medical male circumcision (VMMC) for HIV prevention following the recommendations of the World Health Organization and the Joint United Nations Programme on HIV/AIDS. To inform VMMC target setting, we modeled the impact of circumcising specific client age groups across several Kenyan geographic areas. Methods The Decision Makers’ Program Planning Tool, Version 2 (DMPPT 2) was applied in Kisumu, Siaya, Homa Bay, and Migori counties. Initial modeling done in mid-2016 showed coverage estimates above 100% in age groups and geographic areas where demand for VMMC continued to be high. On the basis of information obtained from country policy makers and VMMC program implementers, we adjusted circumcision coverage for duplicate reporting, county-level population estimates, migration across county boundaries for VMMC services, and replacement of traditional circumcision with circumcisions in the VMMC program. To address residual inflated coverage following these adjustments we applied county-specific correction factors computed by triangulating model results with coverage estimates from population surveys. Results A program record review identified duplicate reporting in Homa Bay, Kisumu, and Siaya. Using county population estimates from the Kenya National Bureau of Statistics, we found that adjusting for migration and correcting for replacement of traditional circumcision with VMMC led to lower estimates of 2016 male circumcision coverage especially for Kisumu, Migori, and Siaya. Even after addressing these issues, overestimation of 2016 male circumcision coverage persisted, especially in Homa Bay. We estimated male circumcision coverage in 2016 by applying correction factors. Modeled estimates for 2016 circumcision coverage for the 10- to 14-year age group ranged from 50% in Homa Bay to approximately 90% in Kisumu. Results for the 15- to 19-year age group suggest almost complete coverage in Kisumu, Migori, and Siaya. Coverage for the 20- to 24-year age group ranged from about 80% in Siaya to about 90% in Homa Bay, coverage for those aged 25–29 years ranged from about 60% in Siaya to 80% in Migori, and coverage in those aged 30–34 years ranged from about 50% in Siaya to about 70% in Migori. Conclusions Our analysis points to solutions for some of the data issues encountered in Kenya. Kenya is the first country in which these data issues have been encountered because baseline circumcision rates were high. We anticipate that some of the modeling methods we developed for Kenya will be applicable in other countries.
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
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    In: PLoS ONE
    Publication Date: 2018-12-19
    Description: by Lise Vlerick, Kathelijne Peremans, Robrecht Dockx, Kurt Audenaert, Chris Baeken, Bart De Spiegeleer, Jimmy Saunders, Ingeborgh Polis Subanaesthetic ketamine has recently been proven to be a highly effective and fast acting alternative treatment for several psychiatric disorders. The mechanisms responsible for ketamine’s antidepressant effects remain unclear, but a possible explanation could be that ketamine interacts with regional cerebral blood flow (rCBF). Therefore, the effects of two subanaesthetic ketamine doses on rCBF were evaluated. Twelve dogs were randomly assigned to one of the three treatment conditions (condition saline, condition 0.5 mg/kg ketamine or condition 2 mg/kg ketamine) and received in total five saline or ketamine infusions, with one week interval. Single Photon Emission Computed Tomography (SPECT) scans with the radiotracer 99m Tc-hexamethylpropylene amine oxime were performed before the start of the infusions (baseline) and 24 hours after the first (single) and last (multiple) infusion. After a wash out period of 3 months, the animals were again assigned to one of the three treatment conditions described above and the infusion/scan protocol was repeated. During the infusions, cardiovascular parameters were evaluated every ten minutes. A one-way repeated measure ANOVA was set up to assess perfusion index for each ketamine dose for the left frontal cortex (alpha = 0.05). The remaining 11 brain regions were post hoc assessed. Perfusion index was significantly increased in the left frontal cortex and in the thalamus 24 hours after single and multiple ketamine infusions compared to baseline in the 2 mg/kg condition. No clinically relevant cardiovascular effects were observed during the ketamine infusions. This study shows that subanaesthetic ketamine can increase neuronal perfusion and therefore alter neuronal function in brain regions involved in depression and anxiety disorders. These perfusion increases may possibly contribute to ketamine’s beneficial effects in these psychiatric disorders.
    Electronic ISSN: 1932-6203
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    In: PLoS ONE
    Publication Date: 2018-12-19
    Description: by Francesca Tamarozzi, Dora Buonfrate, Geraldo Badona Monteiro, Joachim Richter, Federico Giovanni Gobbi, Zeno Bisoffi Background Infection with Schistosoma mansoni is a major cause of morbidity and mortality in endemic areas, and is increasingly diagnosed in migrants and travellers outside transmission areas. Markers for the assessment of morbidity and impact of control programs in endemic areas and for the clinical management of patients in the clinical setting are scant, especially for intestinal involvement. Ultrasonography is well established to evaluate hepatosplenic pathology; on the contrary, ultrasound evaluation of intestinal schistosomiasis is virtually unexplored. In this pilot study, we aimed to describe and evaluate the accuracy of unenhanced intestinal ultrasound for morbidity due to intestinal S . mansoni infection. Methodology/Principal findings We performed a blind case-control study of unenhanced intestinal ultrasound on 107 adults accessing the outpatient clinic of our Centre for Tropical Diseases between January-July 2018 as part of a screening for tropical diseases in migrants and travellers returning from endemic areas. Other clinical and laboratory data were obtained routine examination reports. We could not find any overtly pathological thickness of the gut wall in the sigma, proximal ascending colon, and terminal ileum, in patients with S . mansoni infection (n = 17), S . haematobium infection (n = 7), positive anti-Schistosoma serology (n = 31), and uninfected individuals (n = 52), with no difference among groups as assessed by ANOVA. No polyps or other intestinal abnormalities were visualized. There was no significant change in gut wall thickness one month after treatment with praziquantel in patients with S . mansoni infection (n = 11). Conclusions/Significance Our preliminary results suggest that intestinal ultrasound might not be a sensitive tool for detecting minor intestinal morbidity due to schistosomiasis. Further studies in a hospital setting comparing colonoscopy and ultrasonography may be envisaged; in endemic areas, further studies are needed to describe and assess the usefulness of intestinal ultrasound in patients stratified by infection intensity and compared with markers such as calprotectin and fecal occult blood.
    Electronic ISSN: 1932-6203
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    In: PLoS ONE
    Publication Date: 2018-12-19
    Description: by Motokazu Hojo, Keisuke Fujii, Yuki Inaba, Yoichi Motoyasu, Yoshinobu Kawahara Understanding multi-agent cooperative behavior is challenging in various scientific and engineering domains. In some cases, such as team sports, many cooperative behaviors can be visually categorized and labeled manually by experts. However, these actions which are manually categorized with the same label based on its function have low spatiotemporal similarity. In other words, it is difficult to find similar and different structures of the motions with the same and different labels, respectively. Here, we propose an automatic recognition system for strategic cooperative plays, which are the minimal, basic, and diverse plays in a ball game. Using player’s moving distance, geometric information, and distances among players, the proposed method accurately discriminated not only the cooperative plays in a primary area, i.e., near the ball, but also those distant from a primary area. We also propose a method to classify more detailed types of cooperative plays in various situations. The proposed framework, which sheds light on inconspicuous players to play important roles, could have a potential to detect well-defined and labeled cooperative behaviors.
    Electronic ISSN: 1932-6203
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