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  • University Bibliography  (2,231)
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Source
Language
Publication access
Peer-reviewed
  • 1
    Book
    Book
    New York, NY : Humana
    Keywords: Anthracycline ; Aptamers ; Circular dichroism spectroscopy ; Daunorubicin ; G-quadruplex ; Three-dimensional structure
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: English
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  • 2
    Online Resource
    Online Resource
    Bristol : Institute of Physics Publishing (IOP)
    Keywords: Management und Recht ; Wirtschaftswissenschaften allgemein ; Small rotor blades ; 3D printing ; Gyroid ; PLA ; FDM ; Wind tunnel tests
    Abstract: This study combines the design, the 3D printing and the testing of a small 3-bladed wind turbine rotor for research and teaching purposes. The objective is the additive manufacturing of a rotor with a radius of one meter, as an alternative to subtractive methods, such as computerized milling. The blade design is developed using freely available software packages. The aerodynamic considerations include the airfoil selection, the calculation of the blade geometry and the simulation of the ultimate load cases. The structural considerations are focussed on the printable materials, the infill structures and the retrofit of a load-carrying spar. The rotor blades are 3D printed with the BigRep One at the maker space of the TH Wildau. The structural integrity of the prototype blade is tested in terms of the ultimate root bending moments and the centrifugal forces at the HTW Berlin. The aerodynamic run-up tests are performed at the large wind tunnel of the TU Berlin measuring the power curves. The successful prototype paves the way for follow-up projects, such as open field tests and the 3D printing of larger rotor blades.
    Type of Medium: Online Resource
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 3
    Online Resource
    Online Resource
    München : Hanser
    Keywords: Wirtschaftswissenschaften allgemein
    Type of Medium: Online Resource
    Publication type: Anthology article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: English
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  • 4
    Online Resource
    Online Resource
    Berlin ; Heidelberg : Springer
    Keywords: Angewandte Biowissenschaften ; Biologie allgemein ; 2 ; 4 ; 6-trinitrotoluene ; Explosives ; Heatmap ; MALDI-TOF MS ; Risk analysis ; Smartphone
    Abstract: The use of explosives has led to a widespread distribution of 2,4,6-trinitrotoluene (TNT) and its by- and degradation products in the soil on former production and testing sites. The investigation of those large contaminated sites is so far based on a few selected soil samples, due to high costs of conventional HPLC and GC analysis, although huge differences in concentrations can already be found in small areas and different collection depths. We introduce a novel high-throughput screening system for those areas, which combines a smartphone-based collection of GPS data and soil characteristics with a fast MALDI-TOF MS quantification of explosives in soil sample extracts and finally a heatmap visualization of the explosives’ spread in soil and an analysis of correlation between concentrations and soil characteristics. The analysis of a 400 m2 area presented an extensive contamination with TNT and lower concentrations of the degradation and by-products aminodinitrotoluenes (ADNT) and dinitrotoluenes (DNT) next to a former production facility for TNT. The contamination decreased in deeper soil levels and depended on the soil type. Pure humus samples showed significantly lower contaminations compared to sand and humus/sand mixtures, which is likely to be caused by an increased binding potential of the humic material. No correlation was found between the vegetation and the concentration of explosives. Since the results were obtained and visualized within several hours, the MALDI-TOF MS based comprehensive screening and heatmap analysis might be valuable for a fast and high-throughput characterization of contaminated areas.
    Type of Medium: Online Resource
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 5
    Book
    Book
    Cham : Springer International Publishing
    Keywords: Angewandte Biowissenschaften ; Biologie allgemein ; C60 fullerene-chemotherapy ; Water-soluble drugs ; Nanocomplexes ; Physicochemical characteristics ; Anticancer activity in vitro
    Abstract: Noncovalent water-soluble nanocomplexes of C60 fullerene (C60) with chemotherapeutic drugs (Doxorubicin (Dox), Cisplatin (Cis), and herbal alkaloid Berberine (Ber)) were created. Their anticancer action toward various tumor cells was studied in vitro, addressing specifically their biological synergy, compared with the action of these drugs in the non-immobilized form. Different theoretical and experimental (SEM and AFM microscopy, UV-Vis, DLS, NMR and SANS spectroscopy, ITC calorimetry) methods were applied for getting insight into the nature of the nanocomplexes with drug molecules, as well as into the physical forces enabling stabilization of these complexes. Physicochemical mechanisms were proposed for drug interaction with C60. An enhancement of the toxic action of the created water-soluble C60-drug nanocomplexes toward cancer cells, compared to the action of free drug, was found. Specifically, the C60-Dox nanocomplexes demonstrated ~3.5 higher cytotoxic potential in the leukemic cell lines (CCRF-CEM, Jurkat, THP1, and Molt-16) in comparison with free Dox in the nanometer range of concentrations. Besides, C60 doubled the intracellular level of the up-taken Dox, which also evidenced its function as a nanocarrier. The toxic effect of C60-Cis nanocomplex toward Lewis lung carcinoma (LLC) cells was shown to be higher with IC50 values 3.3 and 4.5 times at 48 h and 72 h, respectively, as compared to the IC50 of free drug. 12.5 μМ Cis had no effect on LLC cells’ viability. The C60-Cis nanocomplex in Cis-equivalent concentration substantially decreased the viability of tumor cells, impaired their shape and adhesion, inhibited migration, and induced their accumulation in the pro-apoptotic sub-G1 phase of cell cycle. An induction of apoptosis by the C60-Cis nanocomplex was confirmed by the activation of caspase 3/7 and externalization of phosphatidylserine on the outer membrane of LLC cells after their double staining with the Annexin V-FITC/PI. The complexation with C60 promoted intracellular uptake of the Ber. An increase in C60 concentration in the C60-Ber nanocomplexes was accompanied by the elevation of their antiproliferative potential toward CCRF-CEM cells in the order: free Ber ˂ 1:2 ˂ 1:1 ˂ 2:1. These findings suggest a universal potential of water-soluble pristine C60 as a unique nano-platform for the delivery of the chemotherapeutic drugs in cytotoxic effect of these drugs.
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: English
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  • 6
    Book
    Book
    Amsterdam : Elsevier
    Keywords: Angewandte Biowissenschaften ; Biologie allgemein ; Direct electron transfer of photosystem I ; Biohybrid photovoltaic system ; Semitransparent three-dimensional material ; Indium tin oxide ; Solution composition ; pH dependence
    Type of Medium: Book
    Publication type: Journal article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: English
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  • 7
    Book
    Book
    New York : Routledge [New York]
    Person(s): Bond, Greg
    Keywords: Wirtschaftswissenschaften allgemein
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Keywords: Maschinenbau allgemein ; Education system ; Labor market ; Labor skill level
    Type of Medium: Online Resource
    Publication type: Anthology article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: English
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  • 9
    Book
    Book
    Basel : MDPI
    Keywords: Informatik/Telematik ; Informatik allgemein ; optical diagnosis imaging ; fluorescence optical imaging ; indocyanine green fluorescence ; image feature ; image analysis ; rheumatoid diseases
    Abstract: Rheumatologists in Europe and the USA increasingly rely on fluorescence optical imaging (FOI, Xiralite) for the diagnosis of inflammatory diseases. Those include rheumatoid arthritis, psoriatic arthritis, and osteoarthritis, among others. Indocyanine green (ICG)-based FOI allows visualization of impaired microcirculation caused by inflammation in both hands in one examination. Thousands of patients are now documented and most literature focuses on inflammatory arthritides, which affect synovial joints and their related structures, making it a powerful tool in the diagnostic process of early undifferentiated arthritis and rheumatoid arthritis. However, it has become gradually clear that this technique has the potential to go even further than that. FOI allows visualization of other types of tissues. This means that FOI can also support the diagnostic process of vasculopathies, myositis, collagenoses, and other connective tissue diseases. This work summarizes the most prominent imaging features found in FOI examinations of inflammatory diseases, outlines the underlying anatomical structures, and introduces a nomenclature for the features and, thus, supports the idea that this tool is a useful part of the imaging repertoire in rheumatology clinical practice, particularly where other imaging methods are not easily available.
    Type of Medium: Book
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 10
    Book
    Book
    London : Routledge
    Keywords: Verwaltungswissenschaft allgemein
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: English
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  • 11
    Book
    Book
    Leipzig : Hochschule für Technik, Wirtschaft und Kultur
    Keywords: Produktion und Material ; Automatisierungstechnik ; Maschinenbau allgemein ; Industrie 5.0 ; Transfer ; Akzeptanzmodell ; sozio-cyberphysische Produktionssysteme
    Abstract: Industrie 4.0 Ansätze haben sich in der fertigenden Industrie vielerorts etabliert. Big Data, IIoT und Künstliche Intelligenz (KI) ermöglichen neue Geschäftsmodelle und wirken sich dadurch auch verändernd auf Produktionssysteme aus. Mit dem Begriff der Industrie 5.0 formuliert sich ein menschzentrierter Ansatz. Die Praxisrelevanz dieser und ähnlicher Innovationen hängt maßgeblich davon ab, wie derartige Einsatzmöglichkeiten neuer, digitaler Technologien in die bestehenden Unternehmensstrukturen Einzug halten. Hierbei kommt es also auf Transfer und Akzeptanz neuer Technologien an. Digitalisierung gestaltet sich somit als sozio-technisches Problem. Dieser Beitrag gibt Einblick in aktuell verfolgte Transferansätze für Digitalisierung im Mittelstand und leistet einen Teil zu Theoriebildung, als dass er auch einen Ausblick auf weitere Aktivitäten in dem Umfeld liefert.
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Open Access
    Peer-reviewed: yes
    Language: German
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  • 12
    Book
    Book
    Berlin : GITO mbH
    Keywords: Informatik/Telematik ; Management und Recht ; Angewandte Informatik ; Verwaltungswissenschaft allgemein ; Öffentliche Online-Dienste ; Datensicherheit und -schutz ; Usable Privacy and Security ; Digital Divide. ; Verwaltungsinformatik ; E-Government ; OZG
    Abstract: Das Projekt „Instrumente zur aktiven und sicheren Verbraucherteilhabe an Online Public Services“ (IVTOPS) analysiert die Verbraucherakzeptanz von öffentlichen Online-Dienste am Beispiel von Nutzerkonten in Berlin und Brandenburg, um geeignete Instrumente zur Überwindung von Akzeptanzbarrieren bzw. Informations- und digitalen Kompetenzasymmetrien bezüglich Datensicherheit und Datenschutz bei der Nutzung von öffentlichen Online-Diensten zu schaffen und zu testen.
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Open Access
    Peer-reviewed: yes
    Language: German
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  • 13
    Book
    Book
    Bingley : Emerald
    Keywords: Verwaltungswissenschaft allgemein
    Abstract: Auditing is a traditional function in the German system of local public finance. Its’ basic mission is to control local finances for accuracy, to avoid misuse of public resources and to support local councils. The priority of auditing is the annual financial statement and accounting, still. Performance is of limited relevance. Given the federal setting of 13 territorial states, the system is complex and fragmented. Another German peculiarity is a parallel structure of financial supervision executed by different public bodies having a particular focus on balanced budget and debt. Local auditing, generally, organises in a two-level structure. The lower level is part of the respective local government, the higher-level is part of the state administration. Beyond this basic setting, there are manifold structural options in place lacking transparency and a clear separation of duties. Private involvement in local auditing is very limited. Legislation guarantees independence of auditing with regard to personal independence, autonomy in auditing issues and methods. Local auditing faces several challenges, as local governments do. However, there is no sound discussion on reforms.
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 14
    Book
    Book
    Berlin : GITO mbH
    Keywords: Informatik/Telematik ; Management und Recht ; Angewandte Informatik ; Erwachsenenbildung ; Verwaltungswissenschaft allgemein ; Wirtschaftswissenschaften allgemein ; Serious Game ; digitale Lernszenarien ; Informationssicherheit ; Sensibilisierung ; KMU
    Abstract: Sensibilisierung für Informationssicherheit und die Förderung entsprechender Kenntnisse sind essentiell für eine gelungene Digitalisierung. Im vorliegenden Projekt werden dafür u. a. digitale Serious Games entwickelt und erprobt. Serious Games bieten in der Nachbildung realistischer Alltagssituationen einen geschützten Raum, in dem Fehler gemacht, Konsequenzen von getroffenen Entscheidungen ohne Folgen für das wahre Leben erlebt und verschiedene Wege ausprobiert werden können. So kann sicherheitsbewusstes Verhalten im Falle eines Angriffs auf die Informationssicherheit eingeübt werden. Die Ergebnisse eines Usertests zeigen, dass narratives Lernen mit Serious Games zum Thema Informationssicherheit positiv angenommen wird und zum Lernerfolg beiträgt.
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Open Access
    Peer-reviewed: yes
    Language: German
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  • 15
    Keywords: industrial demand-side management ; energy-flexible manufacturing systems ; simulation pitfalls ; simulation of material and energy flows
    Abstract: Due to the high share of industry in total electricity consumption, industrial demand-side management can make a relevant contribution to the stability of power systems. At the same time, companies get the opportunity to reduce their electricity procurement costs by taking advantage of increasingly fluctuating prices on short-term electricity markets, the provision of system services on balancing power markets, or by increasing the share of their own consumption from on-site generated renewable energy. Demand-side management requires the ability to react flexibly to the power supply situation without negatively affecting production targets. It also means that the management and operation of production must consider not only production-related parameters but also parameters of energy availability, which further increase the complexity of decision-making. Although simulation studies are a recognized tool for supporting decision-making processes in production and logistics, the simultaneous simulation of material and energy flows has so far been limited mainly to issues of energy efficiency as opposed to energy flexibility, where application-oriented experience is still limited. We assume that the consideration of energy flexibility in the simulation of manufacturing systems will amplify already known pitfalls in conducting simulation studies. Based on five representative industrial use cases, this article provides practitioners with application-oriented experiences of the coupling of energy and material flows in simulation modeling of energy-flexible manufacturing, identifies challenges in the simulation of energy-flexible production systems, and proposes approaches to face these challenges. Seven pitfalls that pose a particular challenge in simulating energy-flexible manufacturing have been identified, and possible solutions and measures for avoiding them are shown. It has been found that, among other things, consistent management of all parties involved, early clarification of energy-related, logistical, and resulting technical requirements for models and software, as well as the application of suitable methods for validation and verification are central to avoiding these pitfalls. The identification and characterization of challenges and the derivation of recommendations for coping with them can raise awareness of typical pitfalls. This paper thus helps to ensure that simulation studies of energy-flexible production systems can be carried out more efficiently in the future.
    Type of Medium: Book
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 16
    Book
    Book
    Wiesbaden : Springer Fachmedien Wiesbaden
    Person(s): Wilkes, Birgit
    Keywords: Informatik/Telematik ; Informatik allgemein ; Smart Home ; Sensortechnik ; Wohnungswirtschaft ; Sturzgefahren ; Hilfsmittel ; Wohnumfeldverbessernde Maßnahmen
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: German
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  • 17
    Book
    Book
    Amsterdam : Elsevier
    Keywords: Verkehr und Logistik ; Mathematik allgemein ; Verkehrswesen ; Periodic Event Scheduling Problem ; Periodic timetabling ; Railway timetabling ; PESPlib ; Benchmark solutions ; Mixed integer programming
    Abstract: We propose a new mixed integer programming based heuristic for computing new benchmark primal solutions for instances of the PESPlib. The PESPlib is a collection of instances for the Periodic Event Scheduling Problem (PESP), comprising periodic timetabling problems inspired by real-world railway timetabling settings, and attracting several international research teams during the last years. We describe two strategies to merge a set of good periodic timetables. These make use of the instance structure and minimum weight cycle bases, finally leading to restricted mixed integer programming formulations with tighter variable bounds. Implementing this timetable merging approach in a concurrent solver, we improve the objective values of the best known solutions for the smallest and largest PESPlib instances by 1.7 and 4.3 percent, respectively.
    Type of Medium: Book
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 18
    Book
    Book
    Stuttgart : Kohlhammer Verlag
    Person(s): Mietzner, Dana
    Keywords: Management und Recht ; Wirtschaftswissenschaften allgemein
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: German
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  • 19
    Book
    Book
    Hamburg : Eurailpress
    Keywords: Verkehrstechnik, Nautik allgemein
    Abstract: Dieser Fragestellung geht das EU-Projekt ASTONRail in einem ersten Projektteil nach. In einer Umfrage wurde die Eisenbahnbranche in Deutschland und Europa hinsichtlich ihrer Erwartungen an die Hochschulausbildung neueingestellter Eisenbahningenieurinnen und -ingenieure befragt. Erkenntnisse und Schlussfolgerungen für die Hochschulausbildung werden nachfolgend vorgestellt.
    Type of Medium: Book
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: German
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  • 20
    Book
    Book
    München : Beck
    Person(s): Meyer, Stephan
    Keywords: Verwaltungswissenschaft allgemein
    Type of Medium: Book
    Publication type: Journal article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: German
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  • 21
    Book
    Book
    Piscataway, NJ : IEEE [Piscataway, NJ]
    Keywords: Angewandte Biowissenschaften ; Biologie allgemein ; convolutional neural network ; image segmentation ; odontogenic maxillary sinusitis ; DICOM
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: English
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  • 22
    Book
    Book
    Washington, DC : Optical Society of America (OSA)
    Keywords: Optische Technologien/Photonik ; Maschinenbau allgemein
    Type of Medium: Book
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 23
    Book
    Book
    Leipzig : Hochschule für Technik, Wirtschaft und Kultur
    Keywords: Maschinenbau allgemein ; SPS ; Codegenerierung ; TIA Portal ; Anlagenautomatisierung ; Softwareentwicklung
    Abstract: Die Programmierung von SPS-Systemen erfolgt hauptsächlich händisch, obwohl große Teile des Programmcodes sehr ähnlich sind und sich häufig nur durch die eingesetzten Variablen unterscheiden. Der Beitrag befasst sich mit der Entwicklung und Testung einer Codegenerierungssoftware für das TIA Portal, um den Zeitaufwand der Programmierung zu reduzieren und Flüchtigkeitsfehler zu vermeiden.
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Open Access
    Peer-reviewed: yes
    Language: German
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  • 24
    Book
    Book
    Atlanta : Association for Information Systems
    Keywords: Verwaltungswissenschaft allgemein ; ethics ; artificial intelligence ; autonomous driving
    Abstract: In recent years, artificial intelligence has essentially contributed to the progress of human society in various application areas. However, it also gave raise to questioning its ethical principles in application domains such as autonomous driving. Despite a plethora of research related to acceptance of autonomously driving vehicles in the MIS research community, how ethical principles are seen by individuals have been mostly left out of consideration so far. The goal of this study is to provide an understanding of how people would like AI-enabled autonomous vehicles to behave. Respondents are asked how they would like to see an autonomous car react in different scenarios, who they think should set the standards for the car behavior, and who they think should be responsible for accidents and crashes involving driverless vehicles. The results of the survey are evaluated both in aggregated form and by means of a cluster analysis.
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 25
    Book
    Book
    Basel : MDPI
    Abstract: Endophytic fungi that colonize the plant root live in an environment with relative high concentrations of different sugars. Analyses of genome sequences indicate that such endophytes can secrete carbohydrate-related enzymes to compete for these sugars with the surrounding plant cells. We hypothesized that typical plant sugars can be used as carbon source by root endophytes and that these sugars also serve as signals to induce the expression and secretion of glycolytic enzymes. The plant-growth-promoting endophytes Serendipita indica and Serendipita herbamans were selected to first determine which sugars promote their growth and biomass formation. Secondly, particular sugars were added to liquid cultures of the fungi to induce intracellular and extracellular enzymatic activities which were measured in mycelia and culture supernatants. The results showed that both fungi cannot feed on melibiose and lactose, but instead use glucose, fructose, sucrose, mannose, arabinose, galactose and xylose as carbohydrate sources. These sugars regulated the cytoplasmic activity of glycolytic enzymes and also their secretion. The levels of induction or repression depended on the type of sugars added to the cultures and differed between the two fungi. Since no conventional signal peptide could be detected in most of the genome sequences encoding the glycolytic enzymes, a non-conventional protein secretory pathway is assumed. The results of the study suggest that root endophytic fungi translocate glycolytic activities into the root, and this process is regulated by the availability of particular plant sugars.
    Type of Medium: Book
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 26
    Book
    Book
    Frankfurt am Main : Wolfgang Metzner Verlag
    Person(s): Bond, Greg
    Keywords: Management und Recht ; Interdisziplinäre Studien (Schwerpunkt Sprach- und Kulturwissenschaften) ; Wirtschaftswissenschaften allgemein
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: English
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  • 27
    Book
    Book
    Basel : MDPI
    Keywords: Optische Technologien/Photonik ; Maschinenbau allgemein ; bi-layers ; quantum point contact model ; memristive device ; embedded applications ; variability ; conductive filament ; CMOS compatibility
    Abstract: The resistive switching properties of HfO2 based 1T-1R memristive devices are electrically modified by adding ultra-thin layers of Al2O3 into the memristive device. Three different types of memristive stacks are fabricated in the 130 nm CMOS technology of IHP. The switching properties of the memristive devices are discussed with respect to forming voltages, low resistance state and high resistance state characteristics and their variabilities. The experimental I–V characteristics of set and reset operations are evaluated by using the quantum point contact model. The properties of the conduction filament in the on and off states of the memristive devices are discussed with respect to the model parameters obtained from the QPC fit.
    Type of Medium: Book
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 28
    Book
    Book
    Basel : MDPI
    Keywords: Optische Technologien/Photonik ; Maschinenbau allgemein ; surface-plasmon resonance ; photonic integrated circuits ; biosensor ; surface functionalization ; label-free detection
    Abstract: Label-free direct-optical biosensors such as surface-plasmon resonance (SPR) spectroscopy has become a gold standard in biochemical analytics in centralized laboratories. Biosensors based on photonic integrated circuits (PIC) are based on the same physical sensing mechanism: evanescent field sensing. PIC-based biosensors can play an important role in healthcare, especially for point-of-care diagnostics, if challenges for a transfer from research laboratory to industrial applications can be overcome. Research is at this threshold, which presents a great opportunity for innovative on-site analyses in the health and environmental sectors. A deeper understanding of the innovative PIC technology is possible by comparing it with the well-established SPR spectroscopy. In this work, we shortly introduce both technologies and reveal similarities and differences. Further, we review some latest advances and compare both technologies in terms of surface functionalization and sensor performance.
    Type of Medium: Book
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 29
    Book
    Book
    Göttingen : Wallstein-Verlag
    Person(s): Bond, Greg
    Keywords: Germanistik (Deutsch, germanische Sprachen ohne Anglistik) allgemein
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Metadata only Access
    Peer-reviewed: yes
    ISBN: 978-3-8353-3934-7
    Language: German
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  • 30
    Book
    Book
    Weinheim : Wiley-VCH
    Keywords: Maschinenbau allgemein ; ALD ; atomic layer deposition ; conductive oxides ; delafossites ; PtCoO 2 topological materials
    Abstract: The first atomic layer deposition process for a ternary oxide is reported, which contains a metal of the platinum group, the delafossite PtCoO2. The deposition with the precursors trimethyl-Pt-methylcyclopentadienyl, Co-bis(N-t-butyl-N′-ethylpropanimidamidate), and oxygen plasma results in a process with a nearly constant growth rate and stoichiometric composition over a wide temperature window from 100 to 320 °C. Annealing of the as-deposited amorphous films in an oxygen atmosphere in a temperature window from 700 to 800 °C leads to the formation of the delafossite phase. Very thin films show a pronounced preferred orientation with the Pt sheets being almost parallel to the substrate surface while arbitrary orientation is observed for thicker films. The conformal coating of narrow trenches highlights the potential of this atomic-layer-deposition process. Moreover, heterostructures with magnetic films are fabricated to demonstrate the potential of PtCoO2 for spintronic applications.
    Type of Medium: Book
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 31
    Book
    Book
    Wildau : Technische Hochschule Wildau
    Keywords: Management und Recht ; Wirtschaftswissenschaften allgemein ; Flughafenregion ; Wirtschaftsstruktur ; Wissenschaftspotenziale ; regionale Entwicklungsbedingungen
    Abstract: Internationale Flughäfen sind wichtige Infrastrukturkomponenten mit der Funktion, vielfältige internationale Austauschprozesse zu ermöglichen. Dabei spielen Face-to-Face Kontakte über große Entfernungen hinweg eine Rolle, die für den Austausch vor allem von implizitem Wissen von großer Bedeutung sind. Bei der Realisierung dieser Funktion stehen Flughäfen in Wechselbeziehungen mit zahlreichen regionalen Entwicklungsbedingungen. Sie nehmen diese in Anspruch und entfalten hierbei vielfältige direkte und indirekte Wirkung auf ihr Umfeld. Auf diese Weise entstehen funktionale Räume, die als Flughafenregionen bezeichnet werden. Das vorliegende Working Paper beschreibt den Status quo der Flughafenregion Berlin-Brandenburg. Dem liegt eine Analyse zugrunde, die von einem Regionenverständnis geleitet ist, das system- und akteursbezogene Perspektiven aufweist. Sie geht weiterhin von der gemeinsamen These verschiedener Ansätze aus der Wirtschaftsgeografie und Innovationsforschung aus, die besagen, dass die Bedeutung räumlicher Nähe der Wissenserzeugung und -anwendung sowie des regionalen, interorganisationalen Lernens für Innovationsprozesse vorteilhaft sind. Charakterisiert wird die Flughafenregion deshalb als Wissenschafts- und Innovationsstandort. Gefragt wird darüber hinaus nach Ansätzen für eine Spezialisierung. Im Ergebnis wird deutlich, dass die Region bereits über starke Potenziale in diesen Bereichen verfügt, gegenwärtig eine hohe Ansiedlungsdynamik aufweist, aber noch kein typisches wirtschaftliches Spezialisierungsmuster ausgeprägt hat. Die zukünftige Entwicklung ist diesbezüglich offen. Im weiteren Verlauf der Szenarioanalyse wird daher der Frage nachgegangen, ob sich Spezialisierungspfade entwickeln werden, welche das sein könnten und wie regionale Entwicklungsbedingungen und Akteurskonstellationen beschaffen sein müssten, um einen solchen Profilierungsprozess zu befördern.
    Type of Medium: Book
    Publication type: Working paper/research report
    Access type: Open Access
    Peer-reviewed: no
    Series Statement: fast track to TRANSFER : Working Paper Series 005
    Language: German
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  • 32
    Keywords: Angewandte Biowissenschaften ; Biologie allgemein
    Abstract: The development of precision cancer medicine relies on novel formulation strategies for targeted drug delivery to increase the therapeutic outcome. Biocompatible polymer nanoparticles, namely dextran-graft-polyacrylamide (D-g-PAA) copolymers, represent one of the innovative non-invasive approaches for drug delivery applications in cancer therapy. In this study, the star-like D-g-PAA copolymer in anionic form (D-g-PAAan) was developed for pH-triggered targeted drug delivery of the common chemotherapeutic drugs – doxorubicin (Dox) and cisplatin (Cis). The initial D-g-PAA copolymer was synthesized by the radical graft polymerization method, and then alkaline-hydrolyzed to get this polymer in anionic form for further use for drug encapsulation. The acidification of the buffer promoted the release of loaded drugs. D-g-PAAan nanoparticles increased the toxic potential of the drugs against human and mouse lung carcinoma cells (A549 and LLC), but not against normal human lung cells (HEL299). The drug-loaded D-g-PAAan-nanoparticles promoted further oxidative stress and apoptosis induction in LLC cells. D-g-PAAan-nanoparticles improved Dox accumulation and drugs’ toxicity in a 3D LLC multi-cellular spheroid model. The data obtained indicate that the strategy of chemotherapeutic drug encapsulation within the branched D-g-PAAan nanoparticle allows not only to realize pH-triggered drug release but also to potentiate its cytotoxic, prooxidant and proapoptotic effects against lung carcinoma cells.
    Type of Medium: Book
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 33
    Book
    Book
    Basel : MDPI
    Keywords: Angewandte Biowissenschaften ; Biologie allgemein ; microfluidic paper analytic device (µPAD) ; patterning glass microfiber ; fiber-electrophoresis chip ; DNA ; imprinted electrodes ; cross layer chip ; polymerase chain reaction (PCR) ; purification
    Abstract: In this work, the fabrication and characterization of a simple, inexpensive, and effective microfluidic paper analytic device (µPAD) for monitoring DNA samples is reported. The glass microfiber-based chip has been fabricated by a new wax-based transfer-printing technique and an electrode printing process. It is capable of moving DNA effectively in a time-dependent fashion. The nucleic acid sample is not damaged by this process and is accumulated in front of the anode, but not directly on the electrode. Thus, further DNA processing is feasible. The system allows the DNA to be purified by separating it from other components in sample mixtures such as proteins. Furthermore, it is demonstrated that DNA can be moved through several layers of the glass fiber material. This proof of concept will provide the basis for the development of rapid test systems, e.g., for the detection of pathogens in water samples.
    Type of Medium: Book
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 34
    Online Resource
    Online Resource
    Keywords: Wirtschaftswissenschaften allgemein ; Google Android ; antitrust ; competition law ; digital ecosystems ; status quo bias ; tying ; abuse of dominance ; unilateral conduct ; iOS ; Apple ; multi-sided markets
    Abstract: On 14 September 2022, the General Court of the European Union largely upheld the landmark Google Android decision of the European Commission of 18 July 2018. The article provides a first assessment of the judgment and its impact on Google and other dominant firms. We explain the contractual background, the Court's key findings, the relevance for pending investigations and similar cases in the digital sphere as well as Google's current compliance with the decision.
    Type of Medium: Online Resource
    Publication type: ePaper
    Access type: Open Access
    Peer-reviewed: no
    Language: English
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  • 35
    Book
    Book
    Piscataway, NJ : IEEE [Piscataway, NJ]
    Keywords: Maschinenbau allgemein ; Graphene ; Growth ; Transfer ; Passivation ; CMOS ; Integration
    Abstract: Due to the unique electronic structures, graphene and other 2D Materials are considered as materials which can enable and extend the functionalities and performance in a large variety of applications, among them in microelectronics. At this point, the investigation and preparation of graphene devices in conditions resembling as close as possible the Si technology environment is of highest importance.Towards these goals, this paper focuses on the full spectra of graphene research aspects in 200mm pilot line. We investigated different process module developments such as CMOS compatible growth of high quality graphene on germanium and its growth mechanisms, transfer related challenges on target substrates, patterning, passivation and various concepts of contacting of graphene on a full 200 mm wafers. Finally, we fabricated proof-of-concept test structures e.g. TLM, Hall bars and capacitor structures to prove the feasibility of graphene processing in the pilot line of IHP.
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: English
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  • 36
    Book
    Book
    Pennington, NJ : Electrochemical Society (ECS)
    Keywords: Optische Technologien/Photonik ; Maschinenbau allgemein
    Type of Medium: Book
    Publication type: Journal article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: English
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  • 37
    Online Resource
    Online Resource
    Basel : MDPI
    Keywords: Angewandte Biowissenschaften ; Biologie allgemein ; myocardial infraction ; heart rate variability ; 10-second heart rate variability ; diagnostics ; machine learning ; k-nearest neighbor classifier ; radial basis function ; decision tree ; random forest
    Abstract: Diagnosis of cardiovascular diseases is an urgent task because they are the main cause of death for 32% of the world’s population. Particularly relevant are automated diagnostics using machine learning methods in the digitalization of healthcare and introduction of personalized medicine in healthcare institutions, including at the individual level when designing smart houses. Therefore, this study aims to analyze short 10-s electrocardiogram measurements taken from 12 leads. In addition, the task is to classify patients with suspected myocardial infarction using machine learning methods. We have developed four models based on the k-nearest neighbor classifier, radial basis function, decision tree, and random forest to do this. An analysis of time parameters showed that the most significant parameters for diagnosing myocardial infraction are SDNN, BPM, and IBI. An experimental investigation was conducted on the data of the open PTB-XL dataset for patients with suspected myocardial infarction. The results showed that, according to the parameters of the short ECG, it is possible to classify patients with a suspected myocardial infraction as sick and healthy with high accuracy. The optimized Random Forest model showed the best performance with an accuracy of 99.63%, and a root mean absolute error is less than 0.004. The proposed novel approach can be used for patients who do not have other indicators of heart attacks.
    Type of Medium: Online Resource
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 38
    Online Resource
    Online Resource
    Washington, DC : Optical Society of America (OSA)
    Keywords: Produktion und Material ; Ingenieurwissenschaften allgemein ; Maschinenbau allgemein ; Mikrosystemtechnik ; Technische/angewandte Optik
    Abstract: Silver halide polycrystalline infrared fibers (PIR) have unique properties such as excellent transmittance in the spectral range from 3 to 17 µm, while also being highly flexible, non-toxic, and non-hygroscopic. They are used in industry and medicine for CO2-laser power delivery, flexible infrared imaging, and remote process spectroscopy. While PIR fibers possess a quite low attenuation (0.1-0.5 dB/m) in the 8-12 µm range, their total transmittance is limited by significant Fresnel reflections at the fiber end faces due to the high refractive index of silver halide (〉2.1). Functionalization of these surfaces with specially designed Anti-Reflective Microstructures (ARMs) enables a striking enhancement of fiber transmittance. In this work, direct imprinting (or embossing) of microstructures to fiber ends and their profiling with a microstructured knife was applied to fabricate such ARMs. The resulting two-dimensional Moth-eye microstructures and one-dimensional microgrooves at the PIR-fiber ends enable to an increase of fiber transmittance in a broadband range of (5-17 µm) as well as to reach up to 20% improvement for PIR-fiber laser cables used for power delivery of CO2-lasers at 10.6 µm.
    Type of Medium: Online Resource
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 39
    Book
    Book
    Oxford : Oxford University Press (OUP)
    Keywords: Angewandte Biowissenschaften ; Biologie allgemein ; avian phylogeny ; bird ; Galápagos ; microsatellite markers ; next-generation DNA sequencing ; population genetics ; Zwillbrocker Venn
    Type of Medium: Book
    Publication type: Journal article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: English
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  • 40
    Book
    Book
    Cambridge : Royal Society of Chemistry (RSC)
    Keywords: Optische Technologien/Photonik ; Maschinenbau allgemein
    Abstract: The possibility of exploiting the enormous potential of graphene for microelectronics and photonics must go through the optimization of the graphene–metal contact. Achieving low contact resistance is essential for the consideration of graphene as a candidate material for electronic and photonic devices. This work has been carried out in an 8′′ wafer pilot-line for the integration of graphene into a CMOS environment. The main focus is to study the impact of the patterning of graphene and passivation on metal–graphene contact resistance. The latter is measured by means of transmission line measurement (TLM) with several contact designs. The presented approaches enable reproducible formation of contact resistivity as low as 660 Ω μm with a sheet resistance of 1.8 kΩ/□ by proper graphene patterning, passivation of the channel and a post-processing treatment such as annealing.
    Type of Medium: Book
    Publication type: Journal article
    Access type: Open Access
    Peer-reviewed: yes
    Language: English
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  • 41
    Online Resource
    Online Resource
    Durham, NC : Research Square
    Keywords: Angewandte Biowissenschaften ; Biologie allgemein ; Ultrasound ; C60 fullerene ; sonodynamic therapy ; HeLa cells ; apoptosis
    Abstract: The acoustic pressure waves of ultrasound (US) penetrate biological tissues deeper than light. Another important feature of US its potential to generate light emission within the excited medium termed sonoluminescence. This promoted the idea of its use as an alternative energy source for photosensitizer excitation. Pristine C60 fullerene (C60), an excellent photosensitizer, was explored in the frame of cancer sonodynamic therapy (SDT). For that purpose, we analyzed C60 effects on human cervix carcinoma HeLa cells in combination with a low intensity US treatment. The time-dependent accumulation of C60 in HeLa cells reached its maximum at 24 h (800 ± 66 ng / 106 cells). Half of extranuclear C60 localized within mitochondria. The efficiency of C60 nanostructure’s sonoexcitation with 1 MHz US was tested with cell viability assay. A significant proapoptotic sonotoxic effect was found for HeLa cells. C60’s ability to induce apoptosis of carcinoma cells after sonoexcitation with US provides a promising novel approach for cancer treatment.
    Type of Medium: Online Resource
    Publication type: ePaper
    Access type: Open Access
    Peer-reviewed: no
    Language: English
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  • 42
    Book
    Book
    Piscataway, NJ : IEEE [Piscataway, NJ]
    Keywords: Optische Technologien/Photonik ; Maschinenbau allgemein
    Type of Medium: Book
    Publication type: Anthology article
    Access type: Metadata only Access
    Peer-reviewed: yes
    Language: English
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  • 43
    Book
    Book
    San Francisco, Calif. : Public Library of Science (PLoS)
    Keywords: Angewandte Biowissenschaften ; Biologie allgemein
    Abstract: Background Cutaneous leishmaniasis (CL) is a vector-borne parasitic diseases of public health importance that is prevalent in the West Bank but not in the Gaza Strip. The disease caused by parasitic protozoans from the genus Leishmania and it is transmitted by infected phlebotomine sand flies. The aim of our study is to investigate the eco-epidemiological parameters and spatiotemporal projections of CL in Palestine over a 30-years period from 1990 through 2020 and to explore future projections until 2060. Methodology/Principal findings This long-term descriptive epidemiological study includes investigation of demographic characteristics of reported patients by the Palestinian Ministry of Health (PMoH). Moreover, we explored spatiotemporal distribution of CL including future projection based on climate change scenarios. The number of CL patients reported during this period was 5855 cases, and the average annual incidence rate (AAIR) was 18.5 cases/105 population. The male to female ratio was 1.25:1. Patients-age ranged from 2 months to 89 years (mean = 22.5, std 18.67, and the median was 18 years). More than 65% of the cases came from three governates in the West Bank; Jenin 29% (1617 cases), Jericho 25% (1403), and Tubas 12% (658) with no cases reported in the Gaza Strip. Seasonal occurrence of CL starts to increase in December and peaked during March and April of the following year. Current distribution of CL indicate that Jericho, Tubas, Jenin and Nablus have the most suitable climatic settings for the sandfly vectors. Future projections until 2060 suggest an increasing incidence from northwest of Jenin down to the southwest of Ramallah, disappearance of the foci in Jericho and Tubas throughout the Jordan Vally, and possible emergence of new foci in Gaza Strip. Conclusions/Significance The future projection of CL in Palestine until 2060 show a tendency of increasing incidence in the north western parts of the West Bank, disappearance from Jericho and Tubas throughout the Jordan Vally, and emergence of new CL endemic foci in the Gaza Strip. These results should be considered to implement effective control and surveillance systems to counteract spatial expansion of CL vectors.
    Type of Medium: Book
    Publication type: Journal article
    Access type: