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  • Nature Publishing Group  (15,104)
  • 2000-2004  (15,104)
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  • 101
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 22 (2004), S. 1339-1340 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] France to import ES cells On 5 October, French Health Minister Philippe Douste-Blazy and Junior Science Minister François d'Aubert unveiled a temporary measure that will permit the import of human embryonic stem (ES) cells into the country for research purposes. The decree will enable ...
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  • 102
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 22 (2004), S. 1347-1348 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: More than 100 countries have ratified the Cartagena Protocol on Biosafety. Identification of genetically modified organisms (GMOs) in the shipping documentation was one of the main contentious issues addressed by the 1st Meeting of the Parties (MOP1) to the Protocol, which took ...
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  • 103
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 22 (2004), S. 1435-1439 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In recent years diverse photolabeling techniques using green fluorescent protein (GFP)-like proteins have been reported, including photoactivatable PA-GFP, photoactivatable protein Kaede, the DsRed 'greening' technique and kindling fluorescent proteins. So far, only PA-GFP, which is monomeric and ...
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  • 104
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    Nature biotechnology 22 (2004), S. 1399-1408 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The past 20 years have seen enormous progress in the understanding of the mechanisms used by the enteric bacterium Escherichia coli to promote protein folding, support protein translocation and handle protein misfolding. Insights from these studies have been exploited to tackle the problems of ...
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  • 105
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 22 (2004), S. 1378-1379 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Implicit in the term discovery is the idea of seeing something new. Yet, chemists for generations have sought to discover new reactions using mechanism-based, hypothesis-driven experiments. Inherent in the experimental design has been a hallmark of invention—the achievement of a molecular ...
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  • 106
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 22 (2004), S. 1343-1346 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The high cost of medicine in America is giving everybody fits. Ask any practitioner of the dismal science of healthcare economics and they will tell you that the conditions are right for a perfect storm. According to a healthcare cost table—originally withheld from the 2004 annual report of ...
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  • 107
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    Nature biotechnology 22 (2004), S. 1349-1350 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Jack A. Heinemann and Terje Traavik reply: Our article points out that the relevance of transgene transfer to biosafety has been dismissed, as if its irrelevance were experimental fact. Davison misses the point by confusing the example of antibiotic-resistance gene transfer from transgenic plants ...
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  • 108
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 22 (2004), S. 1357-1359 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A fierce debate is currently underway concerning the requirements for a marketing authorization for 'biosimilars'—an alternative term for 'biogenerics' recently formally introduced into the drug development lexicon in two guidelines from the European Medicine Agency's (EMEA; London) Committee ...
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  • 109
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 22 (2004), S. 1365-1372 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Just 4 years ago, it was common wisdom that the biopharmaceutical industry was facing a worldwide shortage of manufacturing capacity. The poster child for the crisis was Enbrel (etanercept), a recombinant, soluble receptor for tumor necrosis factor developed by Immunex (Seattle, WA, USA, ...
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  • 110
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    Nature biotechnology 22 (2004), S. 1481-1482 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The right skills will get you a job interview, but only a successful interview will get you the right job. I asked more than 77 experts from academia and the biotechnology and pharmaceutical industries to tell me:(1) what they look for in a candidate and what criteria they use for hiring ...
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  • 111
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    Nature biotechnology 22 (2004), S. 1244-1245 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The ability to monitor changes in glycosylation in tissues and cells by noninvasive means in vivo would provide tremendous advantages for diagnostic and therapeutic purposes, as well as for biological studies. A recent paper in Nature by Bertozzi and colleagues describes a chemical engineering ...
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  • 112
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    Nature biotechnology 22 (2004), S. 1203-1205 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] At first glance, Senomyx's entry into the ranks of public biotechnology companies this past summer was nothing very remarkable. The La Jolla, California-based firm has established a series of cell-based assays to screen combinatorial libraries for novel compounds that modulate G ...
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  • 113
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    Nature biotechnology 22 (2004), S. 1221-1221 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The competition to treat macular degeneration offers biotech investors an exciting story and great investing tips. Where everyone looks, company valuations are usually too rich to allow enough potential return for the risk. But where others avert their eyes, unpopularity may offer the opposite. ...
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  • 114
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    Nature biotechnology 22 (2004), S. 109-112 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] At a conference held in Austria, the European Patent Office (EPO; Munich, Germany), United States Patent and Trademark Office (USPTO; Washington, DC) and Japan Patent Office (JPO; Tokyo, Japan) conducted a comparative study on patent examination guidelines relating to protein three-dimensional ...
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  • 115
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    Nature biotechnology 22 (2004), S. 113-113 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] There is a box associated with this article, available ...
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  • 116
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    Nature biotechnology 22 (2004), S. 20-20 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Last summer, a meeting of the United Nations Organization for Industrial Development (UNIDO, Vienna, Austria) stated that biotechnology can bring to the Latin American and Caribbean region “...sustainable food production and a secure economic system...creating a competitive ...
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  • 117
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    Nature biotechnology 22 (2004), S. 27-27 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Each New Year, the financial media praise and blame 12-month results for stocks, mutual funds, bonds and Tony Blair futures. Biotech investors may well pop a few corks, with the AMEX Biotechnology Index up 36% and iShares Nasdaq Biotech Index 40% higher for the year, as Nature Biotechnology goes to ...
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  • 118
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    Nature biotechnology 22 (2004), S. 37-38 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A major challenge for researchers in the pharmaceutical industry and academicians is determining the mechanisms by which small organic chemicals, such as some drugs, affect living systems. Historically, such mechanism-of-action studies have taken years, if not decades, to reveal relevant proteins ...
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  • 119
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    Nature biotechnology 22 (2004), S. 4-5 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Cardinal Renato Martino and other key Vatican officials seem poised to endorse the use of genetically modified (GM) crops. However, by the end of a seminar, “GMO: threat or hope,” convened by the Pontifical Council of Justice and Peace in Rome on November 10–11, he and several ...
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  • 120
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    Nature biotechnology 22 (2004), S. 38-39 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Only the most experienced and adept surgeons can perform sentinel lymph node biopsy (SLNB), an increasingly popular strategy for determining whether a cancer has spread (metastasized). Some help may be at hand to guide the surgeon's scalpel in the form of a paper reported in this iss- ue by Kim and ...
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  • 121
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    Nature biotechnology 22 (2004), S. 5-6 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A report presented to the UK government and published on November 17 proposes to streamline clinical trials offered through the country's health system, the National Health Service (NHS; London), to provide local biotech companies with a competitive advantage and put the country on the map of ...
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  • 122
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    Nature biotechnology 22 (2004), S. 70-77 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Successful cancer gene therapy requires a vector that systemically and specifically targets tumor cells throughout the body. Although several vectors have been developed to express cytotoxic genes via tumor-specific promoters or to seclectively replicate in tumor cells, most are taken up and ...
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  • 123
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    Nature biotechnology 22 (2004), S. 1169-1169 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Recent patent applications in autoimmune disease research Table ...
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  • 124
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    Nature biotechnology 22 (2004), S. 1171-1171 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Niels Ackermann has been appointed CFO and member of the executive board of Wilex (Munich, Germany). He had been serving as acting CFO since April. Previously, Mr. Ackermann was CFO at Cardion. Oxxon Therapeutics (Oxford, UK) has announced the appointment of Benjamin McNeil Bailey as vice ...
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  • 125
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 22 (2004), S. 1173-1175 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Software Data plotting Systat Software introduces version 9 of its SigmaPlot data analysis and technical graphing software. SigmaPlot 9 is fully compatible with SigmaStat 3.1, Systat's guided statistics package, allowing users to access the most frequently used statistical procedures directly ...
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  • 126
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 22 (2004), S. 1177-1178 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] There are excellent introductory books on Bayesian analysis, but the key ideas behind the buzzword can be grasped quickly. Consider the following gambling puzzle—one that has ancient roots in the origins of both classical and Bayesian probability theory. The table game Alice and Bob are ...
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  • 127
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    Nature biotechnology 22 (2004), S. 1179-1183 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The search for Truth is in one way hard and in another way easy. For it is evident that no one can master it fully nor miss it wholly. But each adds a little to our knowledge of Nature, and from all the facts assembled there arises a certain grandeur. —Aristotle Scientific progress cannot ...
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  • 128
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    Nature biotechnology 22 (2004), S. 1189-1189 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] At a recent conference on strategic human resources (HR), I was pleasantly surprised by the caliber of the presenters as well as of the attendees. The biotechnology industry has certainly come a long way to begin establishing HR as a true business partner. However, many companies still either do ...
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  • 129
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    Nature biotechnology 22 (2004), S. 1161-1165 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We describe a method for selecting aggregation-resistant proteins by heat denaturation. This is illustrated with antibody heavy chain variable domains (dAbs), which are prone to aggregate. The dAbs were displayed multivalently at the infective tip of filamentous bacteriophage, and heated ...
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  • 130
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    Nature biotechnology 22 (2004), S. 1155-1160 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Modified RNA and DNA molecules have novel properties that their natural counterparts do not possess, such as better resistance to degradation in cells and improved pharmacokinetic behavior. In particular, modifications at the 2′-OH of ribose are important for enhancing the stability of RNA. ...
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  • 131
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    Nature biotechnology 22 (2004), S. 1150-1154 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Germline transformation systems for nearly 20 insect species have been derived from transposable elements, allowing the development of transgenic insects for basic and applied studies. These systems use a defective nonautonomous vector that results in stable vector integrations after the ...
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  • 132
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    Nature biotechnology 22 (2004), S. 1053-1054 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Every six months, the software programmers at the molecular-diagnostics business unit of Bayer Diagnostics go back to the drawing board. The programmers responsible for modifying the treatment algorithms for the company's HIV-1-resistance software must update their algorithms regularly because the ...
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  • 133
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    Nature biotechnology 22 (2004), S. 927-927 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The US Biotechnology Industry Organization has joined forces with two philanthropic foundations—the Rockefeller Foundation and the Bill and Melinda Gates Foundation—to form a not-for-profit group dedicated to solving the business problems that biotech companies face in creating products ...
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  • 134
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    Nature biotechnology 22 (2004), S. 927-927 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The momentum that is gathering behind a call for an international registry of clinical trials is still being largely resisted by industry groups. Impending class action suits over the juvenile use of GlaxoSmithKline's Paxil (paroxetine HCl) should keep the topic in the news. The major argument ...
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  • 135
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    Nature biotechnology 22 (2004), S. 929-930 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Several biotech companies on both sides of the Atlantic had to cancel their initial public offerings (IPO) during the second quarter, because of lack of investor confidence. But companies that cannot wait to list because they are under pressure to provide an exit to their original investors have ...
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  • 136
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    Nature biotechnology 22 (2004), S. 930-931 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Increasing pressure for clearly defined patent applications, the completion of the Human Genome Project and the 2000 biotech market bubble could be behind the shrinking number of biotech patents approved in the United States. But industry insiders predict the trend could soon reverse. The number ...
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  • 137
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    Nature biotechnology 22 (2004), S. 931-932 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Several recent deals indicate that Japanese pharmaceutical companies are increasingly willing to invest in early-stage foreign biotech ventures. The trend reflects growing recognition of the potential that foreign biotech R&D can supplement dwindling drug pipelines and signals a bolder ...
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  • 138
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    Nature biotechnology 22 (2004), S. 933-933 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] India announced on June 9 that it is planning to combine its strengths in information technology (IT) and biotechnology to build its first Biotech-IT park, and position itself as a global hub for bioinformatics. But the challenge for Indian bioinformatics companies is to create proprietary products ...
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  • 139
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    Nature biotechnology 22 (2004), S. 935-937 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Pacific population study The entire adult population of the Micronesian island of Kosrae will soon be subjects in a genome-wide association study carried out by scientists from Rockefeller University in New York, Harvard University's Broad Research Institute in Cambridge, Massachusetts, and Yale ...
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  • 140
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    Nature biotechnology 22 (2004), S. 938-938 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A jittery market and hesitant investors befell the biotech sector in the second quarter. For financing, biotech companies are turning increasingly to debt which, excluding public investment in private equities (PIPEs), represented 27% of total funds raised. That's up significantly from the 16% it ...
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  • 141
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    Nature biotechnology 22 (2004), S. 939-941 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The eagerly anticipated launch of the humanized monoclonal antibody Antegren (natalizumab), developed by Biogen Idec of Cambridge, Massachusetts, and Elan of Dublin as a treatment for multiple sclerosis (MS), is poised to shake up a market currently dominated by a handful of products. It could also ...
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  • 142
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    Nature biotechnology 22 (2004), S. 944-944 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Laura DeFrancesco's book review in the June issue (Nat. Biotechnol. 22, 663–664, 2004) exposes many of the biases and flaws of Merrill Goozner's “The $800 Million Pill: The Truth Behind the Cost of New Drugs,” but her criticisms do not go far enough. The ...
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  • 143
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    Nature biotechnology 22 (2004), S. 943-944 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: I read with interest the News in Brief 'BRCA2 patent awarded' by Peter Mitchell from the April issue (Nat. Biotechnol. 22, 373, 2004). Mitchell states that the European patent granted to Cancer Research UK (CRUK) on 11 February 2004 “effectively breaks the monopoly of Myriad ...
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  • 144
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] To the editor: As concerned plant scientists at major plant science research institutions in Japan, we would like to express our collective concern over the impact of Japanese public resistance to plant genetic engineering on the actions of local and national government. We are concerned that ...
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  • 145
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    Nature biotechnology 22 (2004), S. 793-793 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On June 8, a European research consortium laid the first stone of a new high-throughput structural proteomics platform in Grenoble, France. The platform is designed to help find ways of producing high-quality crystals of poorly expressed proteins—a bottleneck in structural biology—so ...
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  • 146
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    Nature biotechnology 22 (2004), S. 795-797 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] New exchange in China China Securities Regulatory Commission (CSRC), the Beijing-based securities watchdog, approved on May 17 the establishment of a small and medium-sized enterprise (SME) board in the Shenzhen Stock Exchange, which is believed to be the beginning of a much awaited NASDAQ-style ...
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    Nature biotechnology 22 (2004), S. 798-798 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Statistics on the biotech sector provided in three reports released in June by investment bank Ernst & Young reveal a 17% growth in revenues to more than $46.5 billion, a 65% decrease in net losses to $4.6 billion, and a 16% trimming of research costs to $18.6 billion. The ...
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    Nature biotechnology 22 (2004), S. 803-803 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: As a representative of a recently formed biosafety discussion group in Mexico with an interest in plant-manufactured products, I and the group applaud your editorial in the February issue (Nat. Biotechnol. 22, 133, 2004) highlighting the controversy over the use of food crops, such ...
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    Nature biotechnology 22 (2004), S. 813-813 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Let me seduce you this month with an enticing thought: you can buy shares in a business for free. Once in a great while, the market will actually value a cash-generating company less than the cash in its checking account. If you can spot the opportunity, risk of loss is very low against potential ...
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    Nature biotechnology 22 (2004), S. 815-816 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In this authoritative and elegantly written book, Harvey Bialy exposes a microcosm of today's medical science in a blistering analysis of the history of modern cancer and AIDS research. An almost unique hybrid of scientific biography and autobiography, Oncogenes, Aneuploidy and AIDS is replete ...
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    Nature biotechnology 22 (2004), S. 817-822 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A broad spectrum of innovative products is currently under development in the agbiotech industry. Most of these opportunities can be classified as meeting needs in either crop productivity (input traits), such as Bayer CropSciences' (Monheim, Germany) herbicide-tolerant canola, or in food, feed and ...
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    Nature biotechnology 22 (2004), S. 823-824 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Metabolic engineering requires both robust approaches to predicting and testing the outcomes of possible pathway manipulations and reliable control mechanisms to subsequently allow the fine tuning of those pathways. Two papers, one recently published in Science and the other in this issue, report ...
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    Nature biotechnology 22 (2004), S. 826-827 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Escherichia coli is adapted to grow at body temperature. When transferred to temperatures much higher or lower than 37 °C, growth slows, endogenous protein production is repressed and proteins required for adaptation to 'temperature stress' are induced. Very early in the history of ...
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    Nature biotechnology 22 (2004), S. 824-826 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Temperature-sensitive mutants have been a mainstay of genetic analysis since the early 20th century. But often such mutants can be difficult to isolate for a protein of interest and, if found, the amino acid changes introduced by the mutation may compromise function. In this issue, Zeidler et al. ...
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    Nature biotechnology 22 (2004), S. 899-899 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Nat. Biotechnol. 22, 385–386 (2004) In Table 1, the sixth entry under “Agency” should have read “National Multiple Sclerosis Society (New York, NY, USA),” not “National Multiple Sclerosis Foundation.” The agency listed exists but it is not the one funding ...
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    Nature biotechnology 22 (2004), S. 901-902 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On April 29, 2004, the United States Congress's Senate Judiciary Committee approved the Cooperative Research and Technology Enhancement (CREATE) Act of 2003 (S 2192), the House version of which was passed on March 10 (HR 2391). The bill will now go to the full Senate for action. If signed into law, ...
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    Nature biotechnology 22 (2004), S. 671-675 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Trend-spotters at the European Commission (Brussels), US Department of Energy (DOE; Washington, DC, USA), Organization for Economic Co-operation and Development (OECD, Paris) and McKinsey & Co. (Frankfurt, Germany) are just a sample of the growing legion of high-profile groups touting something ...
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    Nature biotechnology 22 (2004), S. 677-678 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] An exciting array of novel antiproliferative systemic agents, including angiogenesis inhibitors, vascular targeting agents and signal transduction inhibitors have recently entered into clinical trials. With the exception of imatinib (Gleevec; Novartis, Basel), however, they have had lower than ...
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    Nature biotechnology 22 (2004), S. 679-680 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Fungi are ancient organisms that have long been harnessed for human benefit. Increased understanding of the role of fungal species in nutrient cycling and mycorrhizal associations promises improvements in agricultural practice. In the laboratory, fungi, such as the ascomycetes Saccharomyces ...
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    Nature medicine 10 (2004), S. 884-884 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Amid intense pressure to reduce skyrocketing drug prices, pharmaceutical and biotech companies are trying to devise models that would give poor countries access to medicine while still covering high drug development costs and maintaining incentives for investors.... Experts say differential drug ...
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    Nature medicine 10 (2004), S. 887-892 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The fundamental rationale for cancer immunotherapy lies in the exquisite specificity of both antibodies and T cells (because of their T cell receptor), which allows the immune system to distinguish the most subtle of biochemical differences between cancer and normal cells. The recent explosion of ...
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    Nature medicine 10 (2004), S. 898-900 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Toll-like receptors (TLRs) recognize general features of microorganisms, such as cell-wall lipids, peptidoglycans and stretches of guanine oligonucleotides. This feature enables a swift immune response to invaders but creates the danger of over-reaction to commensal microorganisms, particularly in ...
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    Nature medicine 10 (2004), S. 904-905 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Aside from structures within the nasal cavity, all secondary lymphoid organs, such as spleen, lymph nodes and Peyer's patches, are present and functional in mice just after birth. In this issue, Moyron-Quiroz et al. reveal an additional facet of lymphoid organogenesis, showing that adult mice, upon ...
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    Nature medicine 10 (2004), S. 842-848 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Staphylococcus aureus is a major human pathogen that is associated with diverse types of local and systemic infection characterized by inflammation dominated by polymorphonuclear leukocytes. Staphylococci frequently cause pneumonia, and these clinical isolates often have increased expression of ...
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    Nature medicine 10 (2004), S. 849-857 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Noonan syndrome is a common human autosomal dominant birth defect, characterized by short stature, facial abnormalities, heart defects and possibly increased risk of leukemia. Mutations of Ptpn11 (also known as Shp2), which encodes the protein-tyrosine phosphatase Shp2, occur in ∼50% of ...
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    Nature medicine 10 (2004), S. 656-656 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Hell-bent on economic development, China last year became the third country to launch a man into space. But, down on the ground, poor health care is a sore subject. China's biomedical researchers—and their supporters overseas—are gathering money for an overhaul of the biomedical ...
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    Nature medicine 10 (2004), S. 660-661 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Could the long-standing villain in tobacco yet prove a hero in medicine? Mounting evidence suggests that nicotine can help in certain diseases—but researchers are wary of giving cigarettes a good name. Apoorva Mandavilli reports. Edward Sulzer began smoking when he was a teenager. He ...
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    Nature medicine 10 (2004), S. 665-667 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] This year's “Days of Molecular Medicine” meeting, organized by the Institute of Molecular Medicine of the University of California, San Diego, in collaboration with Nature Medicine and the Wellcome Trust, was the first meeting in this series to be held outside the United States. The ...
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    Nature medicine 10 (2004), S. 674-674 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The idea that memory consolidation is one function of sleep is quite old. So far, the evidence in favor of this notion is correlative: performance of a task that is learned before a good night's sleep improves the next morning. Reporting in Nature, Reto Huber et al. now show that areas of the brain ...
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    Nature medicine 10 (2004), S. 909-915 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Great progress has been made in the field of tumor immunology in the past decade, but optimism about the clinical application of currently available cancer vaccine approaches is based more on surrogate endpoints than on clinical tumor regression. In our cancer vaccine trials of 440 patients, the ...
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    Nature medicine 10 (2004), S. 553-553 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Individualized healthcare, once a seemingly utopian fantasy, is steadily gaining ground as a rational approach to cancer treatment. But recent developments emphasize the need for basic scientific insight as therapies move from the lab to the clinic. In May 2003, the US Food and Drug Administration ...
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    Nature medicine 10 (2004), S. 775-776 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] RNA interference (RNAi), a post-transcriptional gene silencing mechanism first observed in plants and invertebrates, has become an invaluable tool for biologists studying gene function, particularly since its more recent identification in mammalian cells. The discovery that small, sequence-specific ...
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    Nature medicine 10 (2004), S. 782-783 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The concept sounds simple: viruses are adept at delivering their own genes into human tissues, so replace the most harmful viral genes with a therapeutic gene and the pathogen becomes a medicine. But translating the concept of gene therapy into practice has been fraught with obstacles, many ...
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    Nature medicine 10 (2004), S. 786-787 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] A series of clinical studies initiated in the late 1990s brought hope to patients with chronic myeloid leukemia, a low-grade malignancy that eventually transforms to a more aggressive, invariably fatal stage. The drug imatinib mesylate (STI-571, Gleevec), a tyrosine kinase inhibitor, was found to ...
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    Nature medicine 10 (2004), S. 806-810 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The field of vaccinology began in ignorance of how protection was instilled in vaccine recipients. Today, a greater knowledge of immunology allows us to better understand what is being stimulated by various vaccines that leads to their protective effects: that is, their correlates of protection. ...
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    Nature medicine 10 (2004), S. 835-841 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] X-linked immunodeficiency with hyper-IgM (HIGM1), characterized by failure of immunoglobulin isotype switching, is caused by mutations of the CD40 ligand (CD40L), which is normally expressed on activated CD4+ T cells. As constitutive expression of CD40L induces lymphomas, we corrected the mutation ...
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    Nature medicine 10 (2004), S. 655-655 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The European Commission on 28 May launched the world's largest prion disease research network. With 52 centers from 20 countries and a five-year budget of €14.4 million, the NeuroPrion Network aims to understand what causes prion protein modifications, how they develop in animals, and how ...
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    Nature medicine 10 (2004), S. 657-657 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Responding to controversy over the steep price hike of a popular AIDS drug, the US National Institutes of Health (NIH) is assessing whether an obscure law gives the agency the right to 'march in' and force the drug's patent holder to license its patent to generics manufacturers. The US government ...
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    Nature medicine 10 (2004), S. 663-663