WILBERT

Wildauer Bücher+E-Medien Recherche-Tool

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 28 (1983), S. 1-6 
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Endoscopy has become a standard method to evaluate drug-induced damage to the gastroduodenal mucosa; however, studies defining the time course, extent, and duration of the injury in man are unavailable. We report a systematic endoscopic evaluation of the effect of aspirin administration on the gastric mucosa in normal volunteers. Aspirin (2.6 g/day) or placebo was administered for 1 or 7 days. Gastroscopy was performed after 1, 2, 4, and 8 days, and every other day thereafter until the lesions resolved. Submocosal hemorrhages and/or focal erosions were present within 24 hr in all subjects. With continuous aspirin administration, injury was maximal within 3 days and then lessened, ie, damage present after 7 days of aspirin was significantly less than after 1 day of therapy. The time to resolution of the damage was also longer following 1 day than after 7 days of aspirin (median 8 days for 1 day of aspirin vs median 3 days for 7 days of aspirin). Thus, gastric mucosal adaptation occurred and was associated both with less damage and with an accelerated healing process. Acute administration of aspirin produced well-defined areas of submucosal hemorrhages within 2 hr of administration; additional doses increased the area of involvement but not necessarily the severity of involvement.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 28 (1983), S. 13-17 
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract One hundred ambulant outpatients with active, endoscopically proven peptic ulceration entered a double-blind trial of either tripotassium-dicitratobismuthate or placebo. Thirty-four patients had gastric ulceration, 56 had duodenal ulceration, three had both gastric and duodenal ulcers, and two had stomal ulceration. Five patients with gastric ulceration were withdrawn from the trial. Three patients with both gastric and duodenal ulceration and two patients with stomal ulceration were excluded from statistical analysis. After 28 days of tripotassium-dicitratobismuthate 94% of gastric ulcer patients had significant endoscopic healing (P〈0.01). Although 75% of duodenal ulcers healed after 28 days of tripotassium-dicitratobismuthate, this was not statistically significant because of a 60% rate of healing with placebo. Tripotassium-dicitratobismuthate produced a significantly quicker symptomatic response in duodenal ulcer patients (P〈0.01). No serious side effects were recorded, and patient acceptability was high. It is concluded that tripotassium-dicitratobismuthate is an effective agent for promoting gastric ulcer healing and for symptomatic relief in duodenal ulceration.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 28 (1983), S. 18-26 
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Visible changes associated with dysplasia or carcinoma have been assessed in 62 colectomy specimens from patients with ulcerative colitis. In 34 colectomy specimens with one or more carcinomas, there were 51 visible carcinomas and 65 macroscopic dysplastic lesions; only one carcinoma was found in flat mucosa. Among 28 specimens with microscopic dysplasia but no carcinoma, eight contained no visible dysplastic lesion, and the remaining 20 contained a total of 40 polypoid or elevated dysplastic areas. In 32 operative specimens removed for long-standing chronic colitis without dysplasia or carcinoma, nine contained visible inflammatory polypoid lesions. On radiological or endoscopic examination of the colon in long-standing colitis close attention should be given to the identification and biopsy of polyps, elevated nodular areas or plaques, strictures, and isolated ulcers. It is likely that colectomy specimens with visible polypoid or elevated dysplastic lesions will contain a carcinoma more often than those removed for dysplasia in flat mucosa.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 28 (1983), S. 39-43 
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A prospective controlled study of the diagnostic accuracy of blind percutaneous liver biopsy in comparison to laparoscopy plus guided biopsy for the recognition or exclusion of cirrhosis has been performed. One hundred twenty-six patients with a clinical diagnosis of chronic, diffuse, well-compensated liver disease were randomized into two groups and submitted either to percutaneous blind liver biopsy (PB: 64 patients) or to laparoscopy with guided biopsy (LB: 62 patients), in order to assess the accuracy of either procedure in diagnosing cirrhosis. PB correctly recognized or ruled out cirrhosis in 52 patients (82%). Inconclusive results were mostly false negative, as demonstrated by the presence on endoscopy of esophageal varices or by subsequent LB. LB demonstrated presence or absence of cirrhosis in all patients. The difference between the rate of accurate results of the two procedures is statistically significant. It is concluded that in patients without esophageal varices, LB should be the investigation of choice for the assessment of liver structure since the presence of cirrhosis can be missed in up to 20% of cases by PB.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 28 (1983), S. 85-87 
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A patient with Crohn's disease and low serum zinc concentrations is presented who had markedly abnormal dark adaptation. Oral zinc supplementation produced an improvement in dark adaptation, and discontinuation of zinc therapy was associated with a worsening of dark adaptation. Serum vitamin A levels were normal throughout this period. We suggest that impaired retinal function is another manifestation of zinc deficiency in Crohn's disease that may be improved with zinc supplementation.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 28 (1983), S. 61-64 
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recent reports of the association of cimetidine treatment with the development of gastric carcinoma stimulated us to study the effect of chronic cimetidine ingestion on epithelial proliferation in the stomach of male Wistar/Lewis rats. One group of rats received cimetidine in the drinking water to deliver 150–200 mg/kg/day. Control rats received plain water. To label proliferating cells, the rats were injected by tail vein with tritiated thymidine 1 hr before sacrifice at 1, 6, and 12 months. Sections of fundus and antrum were processed for light autoradiography. We found no histological evidence for malignant change and no effect on the measurements of epithelial proliferation by cimetidine in either fundus or antrum at any of the times studied, with the possible exception of an upward shift in the distribution of labeled cells within the proliferative zone of the fundus after 6 months. Thus, under the conditions of our experiments we have been unable to identify an effect of cimetidine on epithelial proliferation which would implicate it as a chemical carcinogen.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 28 (1983), S. 74-84 
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was undertaken to define the earliest ultrastructural changes appearing in the exocrine pancreas and its vasculature during the development of experimental acute pancreatitis induced by the closed duodenal loop technique. Experimental and shamoperated rats were killed at hourly intervals up to 4 hr and at 6 hr postoperatively. Focal acinar cell response included appearance of vacuoles containing uncondensed or partially condensed secretory product, and some rearrangement and dilatation of the rough endoplasmic reticulum within 1 hr. Mild edema was observed and damage to the vascular endothelium developed by 2 hr. At 4 hr focal hemorrhage and a slight inflammatory cell infiltrate was noted which was more prominent at 6 hr. The lack of a correspondence between areas of acinar cell and of vascular abnormalities suggests that factors other than increased secretory back-pressure are involved in the early development of this model of acute pancreatitis.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 28 (1983), S. 88-93 
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Expanding abdominal aortic aneurysms have been reported to produce compression of several vital abdominal structures. A 67-year-old man who developed common bile duct obstruction with jaundice from a contained rupture of an abdominal aortic aneurysm is presented. Diagnosis was made preoperatively with the aid of several modern radiographic techniques. This case illustrates an additional consideration in the differential diagnosis of extrahepatic biliary tract obstruction-expanding or ruptured abdominal aortic aneurysm.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 28 (1983), S. 183-188 
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report describes a patient with pancolitis resulting from rheumatoid vasculitis. Corticosteroid treatment reduced colonic inflammation but colectomy was required to control hemorrhage. The case illustrates the need to recognize colitis as a manifestation of rheumatoid vasculitis so that new treatment modalities may be employed to achieve a more successful medical management. The appearance of discrete colonic ulcerations following corticosteroid treatment of pancolitis in patients with rheumatoid arthritis should further suggest the diagnosis of intestinal vasculitis.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 28 (1983), S. 192-192 
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...