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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 1 (1976), S. 255-258 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to study “in vivo” the distribution kinetics of (-)-nicotine in animals, this molecule was labeled with carbon-11. Two synthesis methods are described. Immediately after intravenous administration of (-)-nicotine-methyl-11C in rabbits the gamma-camera shows a strong radioactivity build-up in the brain and kidneys. The biological interest of this carbon-11 labeled molecule is discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 1 (1976), S. 263-266 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 63-year-old male patient with a small cell bronchial carcinoma on cytotoxic therapy was followed up with the use of liver scintigraphy. In the various scintigrams the remission as well as the late reappearance of the liver metastasis was demonstrated. The abnormalities in the liver scintigrams correlated with the biochemical changes throughout the course.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A method is suggested for the determination of total and divided clearance on the basis of one renal function-excretion. The method, which can also be used for hydronephrotic cases, does not involve blood sampling or the use of a whole-body counter or gamma camera. The method was applied to 73 patients, 14 of whom presented with hydronephrosis. Of the 73 patients, 12 were comparatively examined, and the divided clearance was simultaneously determined in three different ways: (1) graphically, by the areas enclosed between the blood-clearance heart curve and the beginning of the secretion phase of the nephrograms; (2) by catheterizing and measuring the excreted urine from each kidney in a well-crystal detector; (3) by the suggested method without taking blood samples. There was good agreement between the results obtained by the last two methods.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 1 (1976), S. 269-270 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 10 (1985), S. 13-16 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In addition to a recently published case study, we present another three cases in which we observed both lung and renal uptake of technetium Tc 99m sulphur colloid which was related to a period of disseminated intravascular coagulation. Being familiar with this relationship may influence the diagnosis and course of the illness in certain patients.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 10 (1985), S. 33-38 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A method is described for measuring a number of parameters associated with an inorganic ion-exchange krypton generator. These are the activities of rubidium isotopes in inorganic ion-exchange krypton generators, the 81mKr extraction rate, the 81mKr activity delivered to patients during ventilation studies, the elution efficiency, and the radionuclide purity of the eluted gas. The method is based on the calibration of detectors, Ge(Li) and NaI(Tl), with a standardized 114mIn source at matching photon energies. The average activities present in our generators at the end of bombardment (EOB) were 14.6±3.8 mCi (81Rb), 6.2±1.6 mCi (82mRb) and 53±9.4 μCi (83Rb). The 81mKr extraction rate 2 h post-EOB was 10.2±2.3 mCi/min at an air flowrate of 1 l/min. The 81mKr activity delivered to patients during a ventilation study was 91±16 mCi. The elution efficiency of the generators averaged 50%±7% at an air flowrate of 1 l/min. The eluted gas contained Rb radioisotopic impurities in trace quantities of approximately 0.06 μCi/l.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 10 (1985), S. 48-55 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Alpha-aminoisobutyric acid (AIB), or α-methyl alanine, is a nonmetabolized amino acid transported into cells, particularly malignant cells, predominantly by the ‘A’ amino acid transport system. Since it is not metabolized, [1-11C]-AIB can be used to quantify A-type amino acid transport into cells using a relatively simple compartmental model and quantitative imaging procedures (e.g. positron tomography). The tissue distribution of [1-11C]-AIB was determined in six dogs bearing spontaneous tumors, including lymphosarcoma, osteogenic sarcoma, mammary carcinoma, and adenocarcinoma. Quantitative imaging with tissue radioassay confirmation at necropsy showed poor to excellent tumor localization. However, in all cases the concentrations achieved appear adequate for amino acid transport measurement at known tumor locations. The observed low normal brain (due to blood-brain barrier exclusion) and high (relative to brain) tumor concentrations of [1-11C]-AIB suggest that this agent may prove effective for the early detection of human brain tumors.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 10 (1985), S. 60-62 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Following receipt of fission product 99mTc-generators, results of radionuclide purity analysis, performed within 30 min after the first elution, demonstrated detectable levels of a contaminate radionuclide not previously reported. Gamma spectroscopy and half-life determinations confirmed the presence of 82Br. Bromine-82 activity, in eluates from the first elution of 30 generators, received weekly during a 7-month period, ranged from 0.22 μCi (8.235 kBq) to 0.67 μCi (24.68 kBq) per eluate. The ratio of 99Mo to 99mTc ranged from 0.13 nCi to 0.39 nCi per mCi 99mTc. The presence of 82Br in 99mTc-generator eluate resulted in falsely elevated 99Mo assay determinations using whole vial 99Mo assay procedures. For every 0.1 μCi 82Br present in 99mTc eluate the 99Mo assay results were elevated by 1 μCi. Gamma spectroscopy of eluates from additional elutions of these generators failed to detect the presence of 82Br demonstrating the displacement of monovalent bromine anions from the alumina column during the first elution.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 10 (1985), S. 56-59 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Whole-body autoradiography was used to investigate the distribution of acetyl-103-ruthenium-(103Ru)-ruthenocene in female mice 2 and 24 h after intravenous application. Two hours after the application of acetyl-(103Ru)-ruthenocene, the nasal mucosa, colon, lung, liver, spleen and especially the adrenal glands were labelled. After 24 h, apart from the absence of labelling of the colon, the labelling pattern did not differ from that obtained 2 h after application. Again, the adrenal glands were particularly strongly labelled. Microautoradiography was performed to investigate the distribution of acetyl-(103Ru)-ruthenocene within the adrenal glands. It was shown that acetyl-(103Ru)-ruthenocene labelling was restricted to the zona reticularis and the inner zona fasciculata of the adrenal cortex. After the stimulation of glucocorticoid synthesis in the adrenal cortex by adrenocorticotropic hormone (ACTH) pretreatment, the labelled area in the zone fasciculata was clearly enlarged. It is concluded that acetyl-(103Ru)-ruthenocene has an affinity for those regions of the adrenal glands where adrogen and glucocorticoid synthesis occur.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 10 (1985), S. 63-67 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The uptake of 99mTc-methylenediphosphonate (MDP) in different parts of rat femur was simulated using a local three-space model for tracer transfer. The model consisted of bone blood, bone ECF-space and space for tracer deposition. The measured 99mTc-MDP concentration in the systemic blood and the local bone blood flow measured by 131I-macroaggregated albumin microspheres were used as input parameters. The measured blood flow values were 6.3, 3.1 and 15.3 ml/100 g/min for proximal, middle and distal femur, respectively. The model parameters that gave the best fit to measured 99mTc-MDP uptake curves in computer simulation showed that bone blood flow, volume of ECF-space, permeability surface area product and accretion constant from ECF-space to space for tracer deposition were highest in distal and lowest in middle femur. The values corresponded to peak extraction fractions of 0.38, 0.62, and 0.31 for proximal, middle and distal femur, respectively. We conclude that the simulation gives acceptable model parameters, and indicates applicability of a similar model into clinical quantitative bone scintigraphy.
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