Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin
Nature Publishing Group
Nature Archives 1869 - 2009
[Auszug] Perfringolysin O (PFO), a cytolytic toxin secreted by pathogenic Clostridium perfringens, forms large pores in cholesterol-containing membranes. Domain 4 (D4) of the protein interacts first with the membrane and is responsible for cholesterol recognition. By using several independent fluorescence ...
Type of Medium: