THE EFFECTS OF 4-METHYL-2-THIOURACIL ON FIBRE TYPE AND CROSS-SECTIONAL AREA IN THE SOLEUS MUSCLE OF THE RAT
Blackwell Publishing Ltd
Blackwell Publishing Journal Backfiles 1879-2005
1. The effects of 4-methyl-2-thiouracil (MTU, 0.1% in drinking water) on the composition and cross-sectional area of muscle fibres of the rat soleus muscle were studied.2. The percentage of fast twitch-oxidative-glycolytic (FOG) fibres fell after 2 weeks of treatment with MTU to zero at 8 weeks. In contrast the percentage of FOG fibres in untreated animals fell to 19.2±2.1% during this period.3. The mean cross-sectional area of FOG and slow twitch-oxidative (SO) fibres were respectively 39.9% and 23.8% smaller than those of their respective controls 6 weeks after treatment. At 8 weeks the percentage reduction of SO fibre area was 26.8% of the control value.4. This study indicates that MTU treatment causes atrophy and redistribution of fibre type in the soleus muscle.
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